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RPS4X - ribosomal protein S4 X-linked Gene

Also Known as S4; CCG2; RPS4; SCAR; SCR10; DXS306

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6191

About RPS4X

Cytogenetic location: Xq13.1 Genomic coordinates (GRCh38): X:72,272,042-72,277,248 (from NCBI)

This gene has 5 transcripts (splice variants), 169 orthologues and 2 paralogues. Ubiquitous expression in ovary (RPKM 1675.7), lymph node (RPKM 944.2) and 25 other tissues.

Summary

Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes ribosomal protein S4, a component of the 40S subunit. Ribosomal protein S4 is the only ribosomal protein known to be encoded by more than one gene, namely this gene and ribosomal protein S4, Y-linked (RPS4Y). The 2 isoforms encoded by these genes are not identical, but are functionally equivalent. Ribosomal protein S4 belongs to the S4E family of ribosomal proteins. This gene is not subject to X-inactivation. It has been suggested that haploinsufficiency of the ribosomal protein S4 genes plays a role in Turner syndrome; however, this hypothesis is controversial. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

RPS4X Products (1)

mRNA	Protein	Name
NM_001007.5	NP_000998.1	40S ribosomal protein S4, X isoform

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	24965446	GOA
enables structural constituent of ribosome	IDA IDA: Inferred from direct assay	23636399	GOA
enables structural constituent of ribosome	IMP IMP: Inferred from mutant phenotype	8358435	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	1795030	GOA
involved in positive regulation of translation	IMP IMP: Inferred from mutant phenotype	1795030	GOA
involved in ribosomal small subunit biogenesis	IDA IDA: Inferred from direct assay	34516797	GOA
involved in translation	IMP IMP: Inferred from mutant phenotype	8358435	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasmic ribonucleoprotein granule	IDA IDA: Inferred from direct assay	15121898	GOA
located in cytosolic ribosome	IDA IDA: Inferred from direct assay	23636399	GOA
part of cytosolic small ribosomal subunit	IDA IDA: Inferred from direct assay	8706699	GOA
part of ribonucleoprotein complex	IDA IDA: Inferred from direct assay	17289661	GOA
located in ribosome	IDA IDA: Inferred from direct assay	8139551	GOA
part of small ribosomal subunit	IDA IDA: Inferred from direct assay	8139551	GOA
part of small-subunit processome	IDA IDA: Inferred from direct assay	34516797	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RPS4X Protein Structure

RS4NT

Ribosomal_S4e

KOW

0
100
200
263 a.a.

Protein Preferred Names	Protein Names
40S ribosomal protein S4, X isoform	cell cycle gene 2

RPS4X Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RPS4X	P62701	GTF3C3	Homo sapiens	Q9Y5Q9	Y2H Pooling	32814053
Intra	RPS4X	P62701	GTF3C3	Homo sapiens	Q9Y5Q9	Validated Y2H	32814053
Intra	RPS4X	P62701	GTF3C3	Homo sapiens	Q9Y5Q9	Y2H Array	32814053
Intra	RPS4X	P62701	DMWD	Homo sapiens	G5E9A7	Y2H Pooling	32814053
Intra	RPS4X	P62701	DMWD	Homo sapiens	G5E9A7	Validated Y2H	32814053
Intra	RPS4X	P62701	DMWD	Homo sapiens	G5E9A7	Y2H Array	32814053
Intra	RPS4X	P62701	q9y649_human	Homo sapiens	Q9Y649	Validated Y2H	32814053
Intra	RPS4X	P62701	q9y649_human	Homo sapiens	Q9Y649	Y2H Array	32814053
Intra	RPS4X	P62701	q9y649_human	Homo sapiens	Q9Y649	Y2H Pooling	32814053
Intra	RPS4X	P62701	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	RPS4X	P62701	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	RPS4X	P62701	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	RPS4X	P62701	GSN	Homo sapiens	P06396	Validated Y2H	32814053
Intra	RPS4X	P62701	GSN	Homo sapiens	P06396	Y2H Pooling	32814053
Intra	RPS4X	P62701	GSN	Homo sapiens	P06396	Y2H Array	32814053
Intra	RPS4X	P62701	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	RPS4X	P62701	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	RPS4X	P62701	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	RPS4X	P62701	CCK	Homo sapiens	P06307	Validated Y2H	32814053
Intra	RPS4X	P62701	CCK	Homo sapiens	P06307	Y2H Pooling	32814053
Intra	RPS4X	P62701	CCK	Homo sapiens	P06307	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

RPS4X Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P810921	RPS4X Antibody	WB, IHC-P, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Turner Syndrome	Monosomy X Gonadal Dysgenesis Turner Type Ullrich-Turner Syndrome Bonnevie-Ullrich Syndrome Karyotype 45, X Genital Dwarfism, Turner Type Gonadal Dysgenesis 45,X Turner'S Syndrome Gonadal Dysgenesis - Turner Monosomy X Syndrome Xo Syndrome Genital Dwarfism 45, X Syndrome Bonnevie-Ulrich Syndrome Chromosome X Monosomy X Schereshevkii Turner Syndrome Turner Varny Syndrome Ts 45,X Syndrome 45,X/46,Xx Syndrome Turners Syndrome Gonadal Dysgenesis, 45,X X0 Syndrome
Spermatogenic Failure, Y-Linked, 2	SPGFY2 Spermatogenic Failure, Nonobstructive, Y-Linked Y-Linked Spermatogenic Failure 2 Azoospermia, Nonobstructive, Y-Linked Oligozoospermia, Nonobstructive, Y-Linked Oligospermia, Nonobstructive, Y-Linked Spermatogenic Arrest, Y-Linked Nonobstructive Y-Linked Spermatogenic Failure Spermatogenic Failure Y-Linked 2 Azoospermia Non-Obstructive Y-Linked Non-Obstructive Azoospermia And Infertility Oligospermia Non-Obstructive Y-Linked Oligozoospermia Non-Obstructive Y-Linked Spermatogenic Arrest Y-Linked Spermatogenic Failure Nonobstructive Y-Linked
Diamond-Blackfan Anemia	Congenital Pure Red Cell Aplasia Aase Syndrome Erythrogenesis Imperfecta Anemia, Diamond-Blackfan Congenital Hypoplastic Anemia Aase-Smith Ii Syndrome Bds Blackfan-Diamond Anemia Congenital Prca Congenital Hypoplastic Anemia, Blackfan-Diamond Type Dba Blackfan - Diamond Syndrome Chronic Constitutional Pure Red Cell Anaemia Anemia Diamond Blackfan Type Anemia Congenital Erythroid Hypoplastic Aregenerative Anemia Chronic Congenital Blackfan Diamond Syndrome Red Cell Aplasia, Pure Hereditary Aase-Smith Syndrome Ii Bda Blackfan Diamond Anemia Blackfan-Diamond Disease Blackfan-Diamond Syndrome Chronic Congenital Agenerative Anemia Congenital Erythroid Hypoplastic Anemia Congenital Hypoplastic Anemia Of Blackfan And Diamond Congenital Pure Red Cell Anemia Hypoplastic Congenital Anemia Inherited Erythroblastopenia Pure Hereditary Red Cell Aplasia Anemia, Hypoplastic, Congenital Anemia Hypoplastic Congenital Fanconi Anemia Constitutional Aplastic Anemia Diamond-Blackfan Anemia 1 Aase Smith Syndrome 2 Congenital Red Cell Aplasia Red Cell Aplasia Of Infants Pure Red Cell Aplasia Of Infants Congenital Red Cell Aplastic Anaemia Congenital Pure Red Cell Anaemia Congenital Erythroid Hypoplasia Pearson Marrow-Pancreas Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12244	RPS4X Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20099	Rps4x Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26602	Rps4x Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	RPS4X	MGD	MGI:98158
Rattus norvegicus	RPS4X	RGD	RGD:2324318
Others	RPS4X	NCBI