ATG10 - autophagy related 10 Gene

Also Known as APG10; APG10L; pp12616

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 83734

About ATG10

Cytogenetic location: 5q14.1-q14.2 Genomic coordinates (GRCh38): 5:81,972,023-82,256,133 (from NCBI)

This gene has 9 transcripts (splice variants) and 195 orthologues. Ubiquitous expression in testis (RPKM 1.1), thyroid (RPKM 0.8) and 25 other tissues.

Summary

Autophagy is a process for the bulk degradation of cytosolic compartments by lysosomes. ATG10 is an E2-like enzyme involved in 2 ubiquitin-like modifications essential for autophagosome formation: ATG12 (MIM 609608)-ATG5 (MIM 604261) conjugation and modification of a soluble form of MAP-LC3 (MAP1LC3A; MIM 601242), a homolog of yeast Apg8, to a membrane-bound form (Nemoto et al., 2003 [PubMed 12890687]).[supplied by OMIM, Mar 2008]

ATG10 Products (2)

mRNA Protein Name
NM_001131028.2 NP_001124500.1 ubiquitin-like-conjugating enzyme ATG10
NM_031482.5 NP_113670.1 ubiquitin-like-conjugating enzyme ATG10

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables Atg12 conjugating enzyme activity IDA
IDA: Inferred from direct assay
16963840 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in ER overload response IMP
IMP: Inferred from mutant phenotype
17256008 GOA
involved in autophagosome assembly IDA
IDA: Inferred from direct assay
16963840 GOA
involved in autophagy IMP
IMP: Inferred from mutant phenotype
15657430 GOA
involved in protein modification by small protein conjugation IDA
IDA: Inferred from direct assay
16963840 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ATG10 Protein Structure

Autophagy_act_C

Autophagy_act_C: Autophagocytosis associated protein, active-site domain (99 - 167)

  • 0
  • 100
  • 200
  • 220 a.a.
Protein Preferred Names Protein Names

ubiquitin-like-conjugating enzyme ATG10

  • APG10 autophagy 10-like

ATG10 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ATG10 Q9H0Y0 ATG5 Homo sapiens Q9H1Y0
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

ATG10 Antibodies

Cat. No. Product Name Application Reactivity
HY-P80555 ATG10 Antibody (YA603) WB, IP Human
HY-P80555A ATG10 Antibody (YA603)(PBS only) WB, IP Human
HY-P81236 ATG10 Antibody WB, IHC-P Human, Mouse
HY-P84788 ATG10 Antibody (YA4485) WB, FC, ELISA Human
HY-P84788A ATG10 Antibody (YA4485)(PBS only) WB, FC, ELISA Human

Related Diseases

Diseases Alias
Neurodegeneration With Brain Iron Accumulation

  • Nbia

  • Neurodegeneration With Brain Iron Accumulation Disorders

  • Neurodegeneration, With Brain Iron Accumulation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01138 ATG10 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17971 Atg10 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24442 Atg10 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus ATG10 VGNC VGNC:26248
Mus musculus ATG10 MGD MGI:1914045
Felis catus ATG10 VGNC VGNC:102164
Macaca mulatta ATG10 VGNC VGNC:70102
Canis familiaris ATG10 VGNC VGNC:38214
Rattus norvegicus ATG10 RGD RGD:1587624
Others ATG10 NCBI