PPAR alpha
Peroxisome proliferator-activated receptor alpha (PPAR alpha, gene PPARA) is the lipid-activated transcription factor that orchestrates fasting responses in liver, heart and muscle. Activated by fatty acids and eicosanoids, it heterodimerizes with RXR on peroxisome proliferator response elements to induce genes for fatty acid beta-oxidation, ketogenesis and lipoprotein metabolism. PPAR alpha is the molecular target of fibrate drugs such as fenofibrate and gemfibrozil, which lower triglycerides and raise HDL cholesterol, and rodent PPAR alpha activation also drives peroxisome proliferation and hepatocarcinogenesis, a species-specific effect relevant to safety assessment. Expression is high in liver, brown adipose tissue, kidney and heart. Recombinant PPAR alpha ligand-binding domain underpins transactivation and coactivator-binding assays used in metabolic drug discovery.
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PPAR alpha Recombinant Proteins (2)
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Inhibitors & Agonists (141)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
