RCC1 - regulator of chromosome condensation 1 Gene

Also Known as CHC1; RCC1-I

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1104

About RCC1

Cytogenetic location: 1p35.3 Genomic coordinates (GRCh38): 1:28,506,043-28,538,989 (from NCBI)

This gene has 14 transcripts (splice variants), 218 orthologues and 9 paralogues. Ubiquitous expression in testis (RPKM 13.1), lymph node (RPKM 11.7) and 25 other tissues.

Summary

Enables several functions, including guanyl-nucleotide exchange factor activity; nucleosomal DNA binding activity; and protein heterodimerization activity. Involved in several processes, including G1/S transition of mitotic cell cycle; regulation of mitotic nuclear division; and spindle organization. Located in chromatin; cytoplasm; and nucleus. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]

RCC1 Products (6)

mRNA Protein Name
NM_001048194.4 NP_001041659.1 regulator of chromosome condensation isoform a
NM_001048195.4 NP_001041660.1 regulator of chromosome condensation isoform b
NM_001048199.3 NP_001041664.1 regulator of chromosome condensation isoform c
NM_001269.6 NP_001260.1 regulator of chromosome condensation isoform c
NM_001381865.2 NP_001368794.1 regulator of chromosome condensation isoform c
NM_001381866.2 NP_001368795.1 regulator of chromosome condensation isoform c

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables chromatin binding IDA
IDA: Inferred from direct assay
2677018 GOA
enables guanyl-nucleotide exchange factor activity IDA
IDA: Inferred from direct assay
1944575 GOA
enables guanyl-nucleotide exchange factor activity IMP
IMP: Inferred from mutant phenotype
11336674 GOA
enables histone binding IDA
IDA: Inferred from direct assay
11375490 GOA
enables nucleosomal DNA binding IDA
IDA: Inferred from direct assay
17435751 GOA
enables nucleosome binding IMP
IMP: Inferred from mutant phenotype
20347844 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
1961752 GOA
enables protein heterodimerization activity IPI
IPI: Inferred from physical interaction
11336674 GOA
enables small GTPase binding IDA
IDA: Inferred from direct assay
11336674 GOA
enables sulfate binding IDA
IDA: Inferred from direct assay
11336674 GOA
Biological Process GO Annotation Evidence References Source
involved in G1/S transition of mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
3678831 GOA
involved in chromosome segregation IMP
IMP: Inferred from mutant phenotype
17435751 GOA
involved in mitotic spindle organization IDA
IDA: Inferred from direct assay
15014043 GOA
involved in regulation of mitotic nuclear division IDA
IDA: Inferred from direct assay
15014043 GOA
involved in spindle assembly IMP
IMP: Inferred from mutant phenotype
17435751 GOA
Cellular Component GO Annotation Evidence References Source
located in chromatin IDA
IDA: Inferred from direct assay
12121620 GOA
located in condensed nuclear chromosome IDA
IDA: Inferred from direct assay
15014043 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
17435751 GOA
located in nucleus IDA
IDA: Inferred from direct assay
17435751 GOA
part of protein-containing complex IDA
IDA: Inferred from direct assay
11336674 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RCC1 Protein Structure

RCC1

RCC1: Regulator of chromosome condensation (RCC1) repeat (35 - 82)

RCC1

RCC1: Regulator of chromosome condensation (RCC1) repeat (85 - 134)

RCC1

RCC1: Regulator of chromosome condensation (RCC1) repeat (137 - 186)

RCC1

RCC1: Regulator of chromosome condensation (RCC1) repeat (190 - 255)

RCC1

RCC1: Regulator of chromosome condensation (RCC1) repeat (258 - 308)

RCC1

RCC1: Regulator of chromosome condensation (RCC1) repeat (312 - 359)

RCC1

RCC1: Regulator of chromosome condensation (RCC1) repeat (363 - 414)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 421 a.a.
Protein Preferred Names Protein Names

regulator of chromosome condensation

  • cell cycle regulatory protein

RCC1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RCC1 P18754 RAN Homo sapiens P62826
SLC
31467278
Intra
RCC1 P18754 RAN Homo sapiens P62826
Lumier
29997244
Intra
RCC1 P18754 RAN Homo sapiens P62826
MAPPIT
31467278
Intra
RCC1 P18754 RAN Homo sapiens P62826
X-Ray Diffraction
11336674
Intra
RCC1 P18754 XPO1 Homo sapiens O14980
Pull Down
11932251
Intra
RCC1 P18754 RANBP3 Homo sapiens Q9H6Z4
Pull Down
11932251
Intra
RCC1 P18754 RANBP3 Homo sapiens Q9H6Z4
Y2H
11932251
Cross: Cross-species interaction Intra: Intraspecies interaction

RCC1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82897 RCC1 Antibody (YA2642) WB, IHC-P, ICC/IF, FC, IP Human, Mouse, Rat

Related Diseases

Diseases Alias
Microcystic Meningioma
Raynaud Disease

  • Raynaud'S Disease

  • Raynaud Phenomenon

  • Raynaud'S Syndrome

  • Raynaud'S

  • Cold Fingers, Hereditary

  • Raynaud'S Phenomenon

  • Raynaud'S Disease/Phenomenon

  • Raynauds Syndrome

  • Raynauds Phenomenon

  • Secondary Raynaud'S Phenomenon

  • Raynaud Syndrome
Retinitis Pigmentosa 3

  • RP3

  • Retinitis Pigmentosa 15

  • Rp15

  • Choroidoretinal Degeneration With Retinal Reflex In Heterozygous Women

  • Cone-Rod Degeneration, X-Linked

  • Retinitis Pigmentosa Type 15

  • X-Linked Cone-Rod Degeneration

  • X-Linked Retinitis Pigmentosa 3

  • Xlrp3

  • Xlrp-3

  • Retinitis Pigmentosa-3

  • Retinitis Pigmentosa, Type 3
Joubert Syndrome 7

  • JBTS7

  • Cerebello-Oculo-Renal Syndrome 3

  • Cors3

  • Joubert Syndrome, Type 7
Retinitis Pigmentosa

  • RP

  • Rod-Cone Dystrophy

  • Autosomal Recessive Retinitis Pigmentosa

  • Non-Syndromic Retinitis Pigmentosa

  • Pericentral Pigmentary Retinopathy

  • Pigmentary Retinopathy

  • Tapetoretinal Degeneration

  • Rcd

  • Retinitis Pigmentosa Autosomal Recessive

  • ARRP

  • Retinitis Pigmentosa, Autosomal Recessive

  • Retinitis Pigmentosa 1
Cone-Rod Dystrophy 2

  • Cone-Rod Dystrophy

  • CORD2

  • Cone-Rod Retinal Dystrophy

  • Rcrd2

  • Cone-Rod Retinal Dystrophy 2

  • Crd2

  • Cord

  • Crd

  • Retinal Cone-Rod Dystrophy

  • Cone-Rod Retinal Dystrophy-2

  • Retinal Cone-Rod Dystrophy 2

  • Tapetoretinal Degeneration

  • Cone-Rod Degeneration

  • Cone Rod Dystrophy

  • Dystrophy, Cone-Rod

  • Dystrophy, Cone-Rod, Type 2

  • Retinitis Pigmentosa

  • Retinitis Pigmentosa 2

  • Progressive Cone-Rod Dystrophy
Fundus Dystrophy

  • Retinal Dystrophy

  • Retinal Dystrophies

  • Dystrophy, Retinal
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-132304A (1S,4R)-CC-90005 Control 99.95% Unkown
HY-182676 DC541 Inhibitor / Unkown
HY-RS11783 RCC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21417 Rcc1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27936 Rcc1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus RCC1 RGD RGD:1592835
Bos taurus RCC1 VGNC VGNC:33825
Macaca mulatta RCC1 VGNC VGNC:107115
Felis catus RCC1 VGNC VGNC:64544
Mus musculus RCC1 MGD MGI:1913989
Canis familiaris RCC1 VGNC VGNC:45440
Others RCC1 NCBI