2. Epigenetics
  3. Histone Methyltransferase
  4. DC541

DC541 (Compound 20) is a selective NTMT1 inhibitor with an IC50 of 0.34 μM. DC541 reduces the level of me3-RCC1 in colorectal cancer cells. DC541 is applicable to research related to colorectal cancer.

For research use only. We do not sell to patients.

DC541

DC541 Chemical Structure

CAS No. : 2606862-00-2

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DC541 Related Antibodies

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View All Histone Methyltransferase Isoform Specific Products:

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EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D ASH1L/KMT2H SETDB1/KMT2G SETD2/KMT3A NSD2/MMSET/WHSC1 NSD3/WHSC1L1 SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

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Description

DC541 (Compound 20) is a selective NTMT1 inhibitor with an IC50 of 0.34 μM. DC541 reduces the level of me3-RCC1 in colorectal cancer cells. DC541 is applicable to research related to colorectal cancer[1].

In Vitro

DC541 potently inhibits purified NTMT1 with an IC50 of 0.34 μM[1].
DC541 (0.3-300 μM) inhibits the level of me3-RCC1 in colorectal cancer HT29 cells, with an IC50 of approximately 30 μM[1].
DC541 (0.3-300 μM) inhibits the level of me3-RCC1 in colorectal cancer HCT116 cells, with an IC50 of approximately 100 μM[1].
DC541 (up to 1 mM; 24-72 h) exerts no significant cytotoxicity against colorectal cancer HT29 and HCT116 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DC541 Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: human colorectal cancer HT29 and HCT116 cells
Concentration: up to 1 mM
Incubation Time: 24-72 h
Result: Showed no significant reduction in cell viability in HT29 cells at concentrations up to 1 mM across 24 h, 48 h, 72 h incubation time points.
Showed no significant reduction in cell viability in HCT116 cells at concentrations up to 1 mM across 24 h, 48 h, 72 h incubation time points.
Molecular Weight

529.63

Formula

C30H35N5O4
CAS No.
SMILES

O=C(N1[C@@H](CCC1)C(N[C@@H](CCCCN)C(NC2=C(C=CC=C2)C(N)=O)=O)=O)CC3=CC=CC4=C3C=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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DC541 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DC5412606862-00-2DC 541DC-541Histone Methyltransferasecolorectal cancerHCT116 cellsSETD7G9acolorectal cancer cellsNTMT1Protein N-terminal Methyltransferase 1regulator of chromosome condensation 1RCC1HT29 cellsInhibitorinhibitorinhibit

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