PPP1R13L - protein phosphatase 1 regulatory subunit 13 like Gene

Also Known as RAI; RAI4; IASPP; NKIP1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10848

About PPP1R13L

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:45,379,638-45,406,361 (from NCBI)

This gene has 9 transcripts (splice variants), 174 orthologues and is associated with 1 phenotype. Broad expression in skin (RPKM 27.0), placenta (RPKM 6.4) and 14 other tissues.

Summary

IASPP is one of the most evolutionarily conserved inhibitors of p53 (TP53; MIM 191170), whereas ASPP1 (MIM 606455) and ASPP2 (MIM 602143) are activators of p53.[supplied by OMIM, Mar 2008]

PPP1R13L Products (2)

mRNA Protein Name
NM_001142502.2 NP_001135974.1 relA-associated inhibitor
NM_006663.4 NP_006654.2 relA-associated inhibitor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
18275817 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17906639 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of inflammatory response IMP
IMP: Inferred from mutant phenotype
28069640 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPP1R13L Protein Structure

Ank_2

Ank_2: Ankyrin repeats (3 copies) (633 - 720)

SH3_9

SH3_9: Variant SH3 domain (765 - 814)

  • 0
  • 200
  • 400
  • 600
  • 828 a.a.
Protein Preferred Names Protein Names

relA-associated inhibitor

  • NFkB interacting protein 1

PPP1R13L Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PPP1R13L Q8WUF5 RAN Homo sapiens P62826
Pull Down
24855949
Intra
PPP1R13L Q8WUF5 RAN Homo sapiens P62826
SPR
24855949
Intra
PPP1R13L Q8WUF5 PPP1CB Homo sapiens P62140
Anti Tag CoIP
21998301
Intra
PPP1R13L Q8WUF5 PPP1CB Homo sapiens P62140
Anti Tag CoIP
33961781
Intra
PPP1R13L Q8WUF5 PPP1CA Homo sapiens P62136
Anti Bait CoIP
21998301
Intra
PPP1R13L Q8WUF5 PPP1CA Homo sapiens P62136
Anti Tag CoIP
21998301
Intra
PPP1R13L Q8WUF5 TP53 Homo sapiens P04637
Anti Bait CoIP
17906639
Intra
PPP1R13L Q8WUF5 TP53 Homo sapiens P04637
Anti Bait CoIP
23623661
Intra
PPP1R13L Q8WUF5 TP53 Homo sapiens P04637
Anti Bait CoIP
21513714
Intra
PPP1R13L Q8WUF5 TP53 Homo sapiens P04637
Solid Phase Assay
18275817
Intra
PPP1R13L Q8WUF5 TP53 Homo sapiens P04637
IF
23623661
Intra
PPP1R13L Q8WUF5 EP300 Homo sapiens Q09472
Anti Bait CoIP
21513714
Cross
PPP1R13L Q8WUF5 Q9WMX2-PRO_0000037551 Hepatitis C virus Q9WMX2-PRO_0000037551
Y2H Prey Pooling
18985028
Cross
PPP1R13L Q8WUF5 Q9WMX2-PRO_0000037551 Hepatitis C virus Q9WMX2-PRO_0000037551
Pull Down
18985028
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Multiple Congenital Anomalies/Dysmorphic Syndrome
Noonan Syndrome With Multiple Lentigines

  • Leopard Syndrome

  • Multiple Lentigines Syndrome

  • Moynahan Syndrome

  • Cardiomyopathic Lentiginosis

  • Progressive Cardiomyopathic Lentiginosis

  • Cardio-Cutaneous Syndrome

  • Lentiginosis Profusa

  • Capute-Rimoin-Konigsmark-Esterly-Richardson Syndrome

  • Generalized Lentiginosis

  • Gorlin Syndrome Ii

  • Lentiginosis Profusa Syndrome

  • Lentigines, Electrocardiographic Conduction Abnormalities, Ocular Hypertelorism, Pulmonic Stenosis, Abnormal Genitalia, Retardation Of Growth, Deafnes

  • Diffuse Lentiginosis

  • Nsml

  • Familial Multiple Lentigines Syndrome

  • Alopecia-Epilepsy-Intellectual Disability Syndrome, Moynahan Type

  • Progressive Cardiomyopathic Lentiginosis Syndrome

  • Alopecia Epilepsy Oligophrenia Syndrome Of Moynahan
Dilated Cardiomyopathy

  • Familial Dilated Cardiomyopathy

  • Primary Dilated Cardiomyopathy

  • Idiopathic Dilated Cardiomyopathy

  • Congestive Cardiomyopathy

  • Idiopathic Dilation Cardiomyopathy

  • Primary Familial Dilated Cardiomyopathy

  • Cardiomyopathy, Dilated

  • DCM

  • Cardiomyopathy, Familial Dilated

  • Dilated Cardiomyopathy, Familial

  • Hypokinetic Dilated Cardiomyopathy, Familial

  • Familial Idiopathic Cardiomyopathy

  • Fdc

  • Cardiomyopathy, Familial Idiopathic

  • Idiopathic Cardiomegaly

  • Dilated Congestive Cardiomyopathy

  • Chronic Dilated Cardiomyopathy

  • Ccm - [Congestive Cardiomyopathy]

  • Cocm - [Congestive Cardiomyopathy]

  • Dcm - [Dilated Cardiomyopathy]

  • Dilated-Hypokinetic Cardiomyopathy

  • Congestive Idiopathic Cardiomyopathy

  • Primary Idiopathic Dilated Cardiomyopathy
Basal Cell Carcinoma

  • Basal Cell Cancer

  • Basal Cell Neoplasm

  • Basal Cell Carcinoma Of Skin

  • Malignant Basal Cell Tumor

  • Basal Cell Tumor

  • Epithelioma Basal Cell

  • Malignant Basal Cell Neoplasm

  • Rodent Ulcer

  • Carcinoma Basal Cell

  • Neoplasms, Basal Cell

  • Basal Cell Carcinomas

  • Experimental Organism Basal Cell Carcinoma

  • Nodulo-Ulcerative Basal Cell Carcinoma

  • Basalioma

  • Basal Cell Epithelioma Of Skin

  • Bcc - [Basal Cell Carcinoma] Of Skin

  • Rodent Ulcer Of Skin

  • Rodent Ulcer Of Unspecified Site

  • Basal Cell Epithelioma Of Unspecified Site
Testicular Cancer

  • Testis Cancer

  • Testicular Carcinoma

  • Testicular Neoplasms

  • Malignant Neoplasm Of Testis

  • Childhood Neoplasm Of The Testis

  • Neoplasm Of Testis

  • Pediatric Testicular Neoplasm

  • Testicular Tumor

  • Testis Neoplasm

  • Testicular Tumors

  • Testicular Neoplasm

  • Testicular Malignant Germ Cell Tumor

  • Childhood Testicular Neoplasm

  • Carcinoma Of The Testis

  • Cancer Of Testis

  • Malignant Neoplasm Of Testis, Nos

  • Malignant Neoplasm Of Testis, Unspecified

  • Malignant Tumour Of Testis

  • Testicle Cancer

  • Primary Malignant Neoplasm Of Testis
Spinal Chordoma

  • Chordoma Of Spine

  • Vertebral Chordoma
Smith-Magenis Syndrome

  • SMS

  • Chromosome 17p11.2 Deletion Syndrome

  • 17p11.2 Microdeletion Syndrome

  • 17p11.2 Monosomy

  • Chromosome 17p Deletion Syndrome

  • Del(17)

  • P11.2

  • 17p- Syndrome

  • Deletion 17p Syndrome

  • Partial Monosomy 17p
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10982 PPP1R13L Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20668 Ppp1r13l Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27179 Ppp1r13l Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PPP1R13L RGD RGD:1593681
Bos taurus PPP1R13L VGNC VGNC:33225
Mus musculus PPP1R13L MGD MGI:3525053
Canis familiaris PPP1R13L VGNC VGNC:44882
Others PPP1R13L NCBI