SPRY4 - sprouty RTK signaling antagonist 4 Gene

Also Known as HH17

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 81848

About SPRY4

Cytogenetic location: 5q31.3 Genomic coordinates (GRCh38): 5:142,310,430-142,325,021 (from NCBI)

This gene has 6 transcripts (splice variants), 195 orthologues, 3 paralogues and is associated with 5 phenotypes. Broad expression in lung (RPKM 7.4), adrenal (RPKM 7.0) and 24 other tissues.

Summary

This gene encodes a member of a family of cysteine- and proline-rich proteins. The encoded protein is an inhibitor of the receptor-transduced mitogen-activated protein kinase (MAPK) signaling pathway. Activity of this protein impairs the formation of active GTP-RAS. Nucleotide variation in this gene has been associated with hypogonadotropic hypogonadism 17 with or without anosmia. Alternative splicing results in a multiple transcript variants. [provided by RefSeq, Jun 2014]

SPRY4 Products (4)

mRNA	Protein	Name
NM_001127496.3	NP_001120968.1	protein sprouty homolog 4 isoform 2
NM_001293289.3	NP_001280218.1	protein sprouty homolog 4 isoform 2
NM_001293290.3	NP_001280219.1	protein sprouty homolog 4 isoform 2
NM_030964.5	NP_112226.2	protein sprouty homolog 4 isoform 1

SPRY4 Protein Structure

Sprouty

0
100
200
299 a.a.

Protein Preferred Names	Protein Names
protein sprouty homolog 4	sprouty homolog 4

SPRY4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SPRY4	Q9C004	KIF1B	Homo sapiens	O60333-2	Validated Y2H	32814053
Intra	SPRY4	Q9C004	KIF1B	Homo sapiens	O60333-2	Y2H Array	32814053
Intra	SPRY4	Q9C004	KIF1B	Homo sapiens	O60333-2	Y2H Pooling	32814053
Intra	SPRY4	Q9C004	DMWD	Homo sapiens	G5E9A7	Validated Y2H	32814053
Intra	SPRY4	Q9C004	DMWD	Homo sapiens	G5E9A7	Y2H Array	32814053
Intra	SPRY4	Q9C004	DMWD	Homo sapiens	G5E9A7	Y2H Pooling	32814053
Intra	SPRY4	Q9C004	ATN1	Homo sapiens	Q86V38	Y2H Array	32814053
Intra	SPRY4	Q9C004	ATN1	Homo sapiens	Q86V38	Y2H Pooling	32814053
Intra	SPRY4	Q9C004	ATN1	Homo sapiens	Q86V38	Validated Y2H	32814053
Intra	SPRY4	Q9C004	CTSD	Homo sapiens	P07339	Validated Y2H	32814053
Intra	SPRY4	Q9C004	CTSD	Homo sapiens	P07339	Y2H Pooling	32814053
Intra	SPRY4	Q9C004	CTSD	Homo sapiens	P07339	Y2H Array	32814053
Intra	SPRY4	Q9C004	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	SPRY4	Q9C004	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	SPRY4	Q9C004	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	SPRY4	Q9C004	GSN	Homo sapiens	P06396	Y2H Array	32814053
Intra	SPRY4	Q9C004	GSN	Homo sapiens	P06396	Validated Y2H	32814053
Intra	SPRY4	Q9C004	GSN	Homo sapiens	P06396	Y2H Pooling	32814053
Intra	SPRY4	Q9C004	HSPB1	Homo sapiens	P04792	Y2H Array	32814053
Intra	SPRY4	Q9C004	HSPB1	Homo sapiens	P04792	Y2H Pooling	32814053
Intra	SPRY4	Q9C004	HSPB1	Homo sapiens	P04792	Validated Y2H	32814053
Intra	SPRY4	Q9C004	TESK1	Homo sapiens	Q15569	CoIP	12027893
Intra	SPRY4	Q9C004	TESK1	Homo sapiens	Q15569	Y2H	12027893
Intra	SPRY4	Q9C004	RNF11	Homo sapiens	Q9Y3C5	Y2H Array	32814053
Intra	SPRY4	Q9C004	RNF11	Homo sapiens	Q9Y3C5	Y2H Pooling	32814053
Intra	SPRY4	Q9C004	RNF11	Homo sapiens	Q9Y3C5	Validated Y2H	32814053
Intra	SPRY4	Q9C004	PMP22	Homo sapiens	A0A6Q8PF08	Validated Y2H	32814053
Intra	SPRY4	Q9C004	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Pooling	32814053
Intra	SPRY4	Q9C004	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Array	32814053
Intra	SPRY4	Q9C004	CBL	Homo sapiens	P22681	Anti Tag CoIP	18273061
Intra	SPRY4	Q9C004	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	SPRY4	Q9C004	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	SPRY4	Q9C004	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	SPRY4	Q9C004	ZDHHC17	Homo sapiens	Q8IUH5	Y2H Array	24705354
Intra	SPRY4	Q9C004	ZDHHC17	Homo sapiens	Q8IUH5	Lumier	24705354
Intra	SPRY4	Q9C004	TTR	Homo sapiens	P02766	Validated Y2H	32814053
Intra	SPRY4	Q9C004	TTR	Homo sapiens	P02766	Y2H Array	32814053
Intra	SPRY4	Q9C004	TTR	Homo sapiens	P02766	Y2H Pooling	32814053
Intra	SPRY4	Q9C004	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	SPRY4	Q9C004	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	SPRY4	Q9C004	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	SPRY4	Q9C004	COQ8A	Homo sapiens	Q8NI60	Y2H Pooling	32814053
Intra	SPRY4	Q9C004	COQ8A	Homo sapiens	Q8NI60	Validated Y2H	32814053
Intra	SPRY4	Q9C004	COQ8A	Homo sapiens	Q8NI60	Y2H Array	32814053
Intra	SPRY4	Q9C004	PRPS1	Homo sapiens	P60891	Y2H Array	32814053
Intra	SPRY4	Q9C004	PRPS1	Homo sapiens	P60891	Y2H Pooling	32814053
Intra	SPRY4	Q9C004	PRPS1	Homo sapiens	P60891	Validated Y2H	32814053
Intra	SPRY4	Q9C004	PIP4K2B	Homo sapiens	P78356	Anti Tag CoIP	28514442
Intra	SPRY4	Q9C004	PIP4K2B	Homo sapiens	P78356	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

SPRY4 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82035	Sprouty 4 Antibody (YA1780)	WB, ICC/IF, IP, FC	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Hypogonadotropic Hypogonadism 17 With Or Without Anosmia	HH17 Hypogonadism, Hypogonadotropic, Type 17 With/Without Anosmia
Kallmann Syndrome	Hypogonadism With Anosmia Kallman'S Syndrome Anosmic Hypogonadism Anosmic Idiopathic Hypogonadotropic Hypogonadism Hypogonadotropic Hypogonadism And Anosmia Hypogonadotropic Hypogonadism-Anosmia Syndrome Olfacto-Genital Pathological Sequence Familial Hypogonadism With Anosmia Kallman Syndrome Dysplasia Olfactogenitalis Of De Morsier Kallmann'S Syndrome Congenital Hypogonadotropic Hypogonadism With Anosmia
Normosmic Congenital Hypogonadotropic Hypogonadism	Normosmic Idiopathic Hypogonadotropic Hypogonadism Nihh
Hypogonadotropic Hypogonadism 7 With Or Without Anosmia	Idiopathic Hypogonadotropic Hypogonadism HH7 Hypogonadism, Isolated Hypogonadotropic Ihh Hypogonadism, Isolated, Hypogonadotropic Hypogonadotropic Hypogonadism Isolated Hypogonadotropic Hypogonadism Hypogonadotropic Hypogonadism 7 Without Anosmia Congenital Hypogonadotropic Hypogonadism Normosmic Hh Klinefelter Syndrome Isolated Gonadotropin Deficiency
Hypogonadotropic Hypogonadism	Klinefelter Syndrome Klinefelter'S Syndrome Xxy Syndrome Xxy Trisomy Hypogonadotropism 47, Xxy Congenital Idiopathic Hypogonadotropic Hypogonadism Isolated Congenital Gonadotropin Deficiency 47,Xxy Syndrome 47, Xxy Syndrome Klinefelters Syndrome Hypogonadism Klinefelter Syndrome In Males Klinefelter Syndrome, Unspecified Klinefelter Syndrome Karyotype 47, Xxy
Hypogonadism
Legius Syndrome	Neurofibromatosis Type 1-Like Syndrome Nfls LGSS Neurofibromatosis 1-Like Syndrome Neurofibromatosis Type 1 Like Syndrome Nf1-Like Syndrome Neurofibromatosis, Type 1-Like Syndrome
Childhood Germ Cell Cancer	Pediatric Germ Cell Tumor Paediatric Germ Cell Cancer Paediatric Germ Cell Neoplasm Pediatric Germ Cell Cancer Pediatric Germ Cell Neoplasm
Esophageal Basaloid Squamous Cell Carcinoma	Basaloid Squamous Carcinoma Of Esophagus Esophageal Basaloid Carcinoma
Testicular Disease	Testicular Dysfunction Testicular Diseases Disorder Of Testis Testis Disorder Testicular Disorders
Testicular Germ Cell Cancer	Germ Cell Tumor Of Testis Testicular Germ Cell Tumor Testicular Germ Cell Neoplasm Testicular Malignant Germ Cell Tumor
Sensorineural Hearing Loss	Sensory Hearing Loss Sensorineural Deafness Sensorineural Hearing Loss Disorder Hearing Loss, Sensorineural Central Hearing Loss High Frequency Deafness High Frequency Hearing Loss High-Frequency Hearing Loss Perceptive Deafness Perceptive Hearing Loss Perceptive Hearing Loss Or Deafness Hearing Loss Sensorineural Deafness Sensorineural Hearing Loss High-Frequency Hearing Loss, Central Hearing Loss, High-Frequency
Cryptorchidism, Unilateral Or Bilateral	Cryptorchidism Undescended Testicle Undescended Testis Cryptorchism Undescended Testicles CRYPTO Impaired Testicular Descent Cryptosporidiosis Retained Testis Unilateral Cryptorchidism Unilateral Undescended Testis Nondescent Unilateral Testicle Unilateral Cryptorchism Ectopic Testis, Unilateral Bilateral Cryptorchidism Bilateral Cryptorchism Bilateral Nondescent Testicle Bilateral Undescended Testes Bilateral Ectopic Testes
Testicular Cancer	Testis Cancer Testicular Carcinoma Testicular Neoplasms Malignant Neoplasm Of Testis Childhood Neoplasm Of The Testis Neoplasm Of Testis Pediatric Testicular Neoplasm Testicular Tumor Testis Neoplasm Testicular Tumors Testicular Neoplasm Testicular Malignant Germ Cell Tumor Childhood Testicular Neoplasm Carcinoma Of The Testis Cancer Of Testis Malignant Neoplasm Of Testis, Nos Malignant Neoplasm Of Testis, Unspecified Malignant Tumour Of Testis Testicle Cancer Primary Malignant Neoplasm Of Testis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-202699	SHOC2-RAS PPI-IN-1	Inhibitor	99.50%	Unkown
HY-181889	KRAS G12C-IN-75	Inhibitor	/	Unkown
HY-RS13724	SPRY4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22828	Spry4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29343	Spry4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SPRY4	VGNC	VGNC:35244
Macaca mulatta	SPRY4	VGNC	VGNC:77925
Canis familiaris	SPRY4	VGNC	VGNC:46767
Rattus norvegicus	SPRY4	RGD	RGD:1305324
Mus musculus	SPRY4	MGD	MGI:1345144
Felis catus	SPRY4	VGNC	VGNC:102332
Others	SPRY4	NCBI