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PHF23 - PHD finger protein 23 Gene

Also Known as hJUNE-1b

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 79142

About PHF23

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:7,235,038-7,240,828 (from NCBI)

This gene has 13 transcripts (splice variants), 212 orthologues and 1 paralogue. Ubiquitous expression in esophagus (RPKM 12.0), testis (RPKM 11.9) and 25 other tissues.

Summary

Predicted to enable metal ion binding activity. Involved in negative regulation of autophagosome assembly; negative regulation of autophagosome maturation; and positive regulation of protein ubiquitination. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

PHF23 Products (3)

mRNA	Protein	Name
NM_001284517.2	NP_001271446.1	PHD finger protein 23 isoform 2
NM_001284518.2	NP_001271447.1	PHD finger protein 23 isoform 3
NM_024297.3	NP_077273.2	PHD finger protein 23 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25484098	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of autophagosome assembly	IMP IMP: Inferred from mutant phenotype	25484098	GOA
involved in negative regulation of autophagosome maturation	IMP IMP: Inferred from mutant phenotype	25484098	GOA
involved in positive regulation of protein ubiquitination	IMP IMP: Inferred from mutant phenotype	25484098	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PHF23 Protein Structure

PHD

0
100
200
300
403 a.a.

Protein Preferred Names	Protein Names
PHD finger protein 23	PDH-containing protein JUNE-1

PHF23 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PHF23	Q9BUL5	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	PHF23	Q9BUL5	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	PHF23	Q9BUL5	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	PHF23	Q9BUL5	HRAS	Homo sapiens	P01112	Validated Y2H	32814053
Intra	PHF23	Q9BUL5	HRAS	Homo sapiens	P01112	Y2H Array	32814053
Intra	PHF23	Q9BUL5	HRAS	Homo sapiens	P01112	Y2H Pooling	32814053
Intra	PHF23	Q9BUL5	GSN	Homo sapiens	P06396	Validated Y2H	32814053
Intra	PHF23	Q9BUL5	GSN	Homo sapiens	P06396	Y2H Pooling	32814053
Intra	PHF23	Q9BUL5	GSN	Homo sapiens	P06396	Y2H Array	32814053
Intra	PHF23	Q9BUL5	CYCS	Homo sapiens	P99999	Y2H Array	32814053
Intra	PHF23	Q9BUL5	CYCS	Homo sapiens	P99999	Validated Y2H	32814053
Intra	PHF23	Q9BUL5	CYCS	Homo sapiens	P99999	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Myasthenic Syndrome, Congenital, 5	Endplate Acetylcholinesterase Deficiency Congenital Myasthenic Syndrome 5 CMS5 Ead Engel Congenital Myasthenic Syndrome Myasthenic Syndrome, Congenital, Engel Type Cms Ic Congenital Myasthenic Syndrome Type Ic Congenital Myasthenic Syndrome Type Ic, Formerly Cms1c, Formerly Cms Ic, Formerly Congenital Myasthenic Syndrome Engel Type End Plate Acetylcholinesterase Deficiency Synaptic Congenital Myasthenic Syndromes Cms1c Cmse Congenital Myasthenic Syndrome Type 1c End-Plate Acetylcholinesterase Deficiency Myasthenic Syndrome, Congenital, Type 5
Charcot-Marie-Tooth Disease, Axonal, Type 2e	Charcot-Marie-Tooth Disease Type 2 CMT2E CMT2S CMT2Y Charcot-Marie-Tooth Disease Type 2e Charcot-Marie-Tooth Disease Type 2y Charcot-Marie-Tooth Disease Axonal Type 2s Charcot-Marie-Tooth Disease, Axonal, Type 2s Charcot-Marie-Tooth Disease, Type 2e Hereditary Motor And Sensory Neuropathy Type 2 Charcot-Marie-Tooth Neuropathy, Type 2s Charcot-Marie-Tooth Disease, Axonal, Autosomal Recessive, Type 2s Charcot-Marie-Tooth Disease, Axonal, Type 2y Charcot-Marie-Tooth Disease, Axonal, Autosomal Dominant, Type 2y Charcot-Marie-Tooth Neuropathy, Type 2y Charcot-Marie-Tooth Disease, Type 2y Autosomal Dominant Charcot-Marie-Tooth Disease Type 2e Charcot-Marie-Tooth Neuropathy Type 2e Autosomal Dominant Charcot-Marie-Tooth Disease Type 2 Due To Vcp Mutation Cmt2 Due To Vcp Mutation Charcot-Marie-Tooth Disease Type 2s Autosomal Dominant Charcot-Marie-Tooth Disease Type 2 Autosomal Dominant Axonal Charcot-Marie-Tooth Disease Cmt2 Charcot-Marie-Tooth Neuropathy, Type 2e Hereditary Motor And Sensory Neuropathy Guadalajara Neuronal Type Hereditary Motor And Sensory Neuropathy Okinawa Type Autosomal Dominant Axonal Charcot-Marie-Tooth Type 2y Charcot-Marie-Tooth Neuropathy Type 2y Autosomal Recessive Axonal Charcot-Marie-Tooth Type 2s Charcot-Marie-Tooth Neuropathy Type 2s Charcot-Marie-Tooth Type 2 Autosomal Dominant Charcot-Marie-Tooth Disease Type 2y Charcot-Marie-Tooth Disease 2e Charcot-Marie-Tooth Disease Axonal Type 2e Charcot-Marie-Tooth Disease Neuronal Type 2e Charcot-Marie-Tooth Disease 2s Charcot-Marie-Tooth Neuropathy Axonal Type 2s Charcot-Marie-Tooth Disease 2y Charcot-Marie-Tooth Disease, Type 2 Hereditary Motor And Sensory-Neuropathy Type Ii

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10425	PHF23 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22724	Phf23 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29238	Phf23 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PHF23	MGD	MGI:1925496
Macaca mulatta	PHF23	VGNC	VGNC:75877
Bos taurus	PHF23	VGNC	VGNC:32823
Canis familiaris	PHF23	VGNC	VGNC:44488
Rattus norvegicus	PHF23	RGD	RGD:1302969
Felis catus	PHF23	VGNC	VGNC:64144
Others	PHF23	NCBI