HOXB2 - homeobox B2 Gene

Also Known as K8; HOX2; HOX2H; Hox-2.8

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3212

About HOXB2

Cytogenetic location: 17q21.32 Genomic coordinates (GRCh38): 17:48,542,655-48,545,109 (from NCBI)

This gene has 3 transcripts (splice variants), 194 orthologues and 42 paralogues. Broad expression in kidney (RPKM 11.3), fat (RPKM 6.5) and 19 other tissues.

Summary

This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with pancreatic Cancer. [provided by RefSeq, Jul 2008]

HOXB2 Products (1)

mRNA Protein Name
NM_002145.4 NP_002136.1 homeobox protein Hox-B2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
15289435 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
12080061 GOA
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
23332764 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
15289435 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HOXB2 Protein Structure

Homeobox

Homeobox: Homeobox domain (144 - 200)

  • 0
  • 100
  • 200
  • 300
  • 356 a.a.
Protein Preferred Names Protein Names

homeobox protein Hox-B2

  • K8 home protein

HOXB2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
HOXB2 P14652 MID2 Homo sapiens Q9UJV3-2
Validated Y2H
32296183
Intra
HOXB2 P14652 NDOR1 Homo sapiens Q9UHB4
Validated Y2H
32296183
Intra
HOXB2 P14652 PBX4 Homo sapiens Q9BYU1
Validated Y2H
32296183
Intra
HOXB2 P14652 ZNF410 Homo sapiens Q86VK4-3
Validated Y2H
32296183
Intra
HOXB2 P14652 RUNX1T1 Homo sapiens Q06455-2
Validated Y2H
32296183
Intra
HOXB2 P14652 UBASH3B Homo sapiens Q8TF42
Validated Y2H
32296183
Intra
HOXB2 P14652 TNKS2 Homo sapiens Q9H2K2
Anti Tag CoIP
35016035
Intra
HOXB2 P14652 DTX2 Homo sapiens Q86UW9
Validated Y2H
32296183
Intra
HOXB2 P14652 MORN3 Homo sapiens Q6PF18
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

HOXB2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P810888 HOXB2 Antibody WB, IHC-P, ICC/IF Human, Mouse, Rat

Related Diseases

Diseases Alias
Pancreatic Cancer

  • Pancreatic Carcinoma

  • Carcinoma Of Pancreas

  • Familial Pancreatic Carcinoma

  • Pancreatic Neoplasm

  • Pancreatic Carcinoma, Familial

  • Malignant Neoplasm Of Pancreas

  • Pancreatic Acinar Carcinoma

  • Pancreatic Tumor

  • Familial Pancreatic Cancer

  • Neoplasm Of The Pancreas

  • Cancer Of The Pancreas

  • Pancreatic Carcinoma, Somatic

  • Pancreatic Cancer, Somatic

  • Ca Body Of Pancreas

  • Ca Head Of Pancreas

  • Ca Tail Of Pancreas

  • Malignant Neoplasm Of Body Of Pancreas

  • Malignant Neoplasm Of Head Of Pancreas

  • Malignant Neoplasm Of Tail Of Pancreas

  • Pancreas Neoplasm

  • Exocrine Cancer

  • Exocrine Pancreas Carcinoma

  • Hereditary Pancreatic Cancer

  • Hereditary Pancreatic Carcinoma

  • PNCA

  • Pancreatic Cancer, Susceptibility To

  • Carcinoma Of Head Of Pancreas

  • Pancreatic Neoplasms

  • Pancreatic Tumors

  • Cancer, Pancreatic

  • Cancer Of Pancreas

  • Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06306 HOXB2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris HOXB2 VGNC VGNC:54955
Bos taurus HOXB2 VGNC VGNC:29918
Felis catus HOXB2 VGNC VGNC:99077
Mus musculus HOXB2 MGD MGI:96183
Rattus norvegicus HOXB2 RGD RGD:2319509
Others HOXB2 NCBI