TNKS2 - tankyrase 2 Gene

Also Known as TNKL; ARTD6; TANK2; pART6; PARP5B; PARP5C; PARP-5b; PARP-5c

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 80351

About TNKS2

Cytogenetic location: 10q23.32 Genomic coordinates (GRCh38): 10:91,798,426-91,865,475 (from NCBI)

This gene has 1 transcript (splice variant), 169 orthologues and 2 paralogues. Ubiquitous expression in thyroid (RPKM 15.7), placenta (RPKM 12.5) and 25 other tissues.

Summary

Enables NAD+ ADP-ribosyltransferase activity; enzyme binding activity; and protein ADP-ribosylase activity. Involved in several processes, including protein ADP-ribosylation; protein localization to chromosome, telomeric region; and regulation of telomere maintenance. Located in nuclear envelope; pericentriolar material; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

TNKS2 Products (6)

mRNA Protein Name
XM_011540213.2 XP_011538515.1 poly [ADP-ribose] polymerase tankyrase-2 isoform X1
XM_047425795.1 XP_047281751.1 poly [ADP-ribose] polymerase tankyrase-2 isoform X5
XM_017016701.2 XP_016872190.1 poly [ADP-ribose] polymerase tankyrase-2 isoform X4
NM_025235.4 NP_079511.1 poly [ADP-ribose] polymerase tankyrase-2
XM_017016699.2 XP_016872188.1 poly [ADP-ribose] polymerase tankyrase-2 isoform X2
XM_017016700.3 XP_016872189.2 poly [ADP-ribose] polymerase tankyrase-2 isoform X3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables NAD+-protein ADP-ribosyltransferase activity IDA
IDA: Inferred from direct assay
11739745 GOA
enables NAD+-protein poly-ADP-ribosyltransferase activity IDA
IDA: Inferred from direct assay
19759537 GOA
enables enzyme binding IPI
IPI: Inferred from physical interaction
21251231 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11854288 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of telomere maintenance via telomere lengthening IMP
IMP: Inferred from mutant phenotype
25939383 GOA
involved in positive regulation of canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
19759537 GOA
involved in positive regulation of telomere capping IMP
IMP: Inferred from mutant phenotype
25939383 GOA
involved in protein auto-ADP-ribosylation IDA
IDA: Inferred from direct assay
21478859 GOA
involved in protein localization to chromosome, telomeric region IMP
IMP: Inferred from mutant phenotype
11739745 GOA
involved in protein poly-ADP-ribosylation IDA
IDA: Inferred from direct assay
25043379 GOA
involved in protein polyubiquitination IDA
IDA: Inferred from direct assay
19759537 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
11278563 GOA
located in nuclear envelope IDA
IDA: Inferred from direct assay
11454873 GOA
located in nucleus IDA
IDA: Inferred from direct assay
11739745 GOA
located in pericentriolar material IDA
IDA: Inferred from direct assay
11454873 GOA
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
11454873 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TNKS2 Protein Structure

Ank_2

Ank_2: Ankyrin repeats (3 copies) (28 - 121)

Ank

Ank: Ankyrin repeat (125 - 154)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (215 - 305)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (338 - 429)

Ank

Ank: Ankyrin repeat (433 - 461)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (496 - 589)

Ank_4

Ank_4: Ankyrin repeats (many copies) (594 - 631)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (683 - 775)

SAM_2

SAM_2: SAM domain (Sterile alpha motif) (877 - 933)

PARP

PARP: Poly(ADP-ribose) polymerase catalytic domain (955 - 1156)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1166 a.a.
Protein Preferred Names Protein Names

poly [ADP-ribose] polymerase tankyrase-2

  • ADP-ribosyltransferase diphtheria toxin-like 6

  • TNKS-2

  • TRF1-interacting ankyrin-related ADP-ribose polymerase 2

  • poly [ADP-ribose] polymerase 5B

  • protein poly-ADP-ribosyltransferase tankyrase-2

  • tankyrase II

  • tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2

  • tankyrase-like protein

  • tankyrase-related protein

TNKS2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TNKS2 Q9H2K2 STRN Homo sapiens O43815
Pull Down
22153077
Intra
TNKS2 Q9H2K2 ARPIN Homo sapiens Q7Z6K5-1
X-Ray Diffraction
26774128
Intra
TNKS2 Q9H2K2 ARPIN Homo sapiens Q7Z6K5-1
SAXS
26774128
Intra
TNKS2 Q9H2K2 ARPIN Homo sapiens Q7Z6K5-1
ITC
26774128
Intra
TNKS2 Q9H2K2 ARPIN Homo sapiens Q7Z6K5-1
GMS
26774128
Intra
TNKS2 Q9H2K2 TNKS1BP1 Homo sapiens Q9C0C2
Pull Down
12080061
Intra
TNKS2 Q9H2K2 TNKS1BP1 Homo sapiens Q9C0C2
FPS
22153077
Intra
TNKS2 Q9H2K2 USP25 Homo sapiens Q9UHP3
FPS
22153077
Intra
TNKS2 Q9H2K2 LNPEP Homo sapiens Q9UIQ6
Pull Down
12080061
Intra
TNKS2 Q9H2K2 LNPEP Homo sapiens Q9UIQ6
FPS
22153077
Intra
TNKS2 Q9H2K2 ANKRD28 Homo sapiens O15084
Y2H Fragment Pooling
23414517
Intra
TNKS2 Q9H2K2 NUMA1 Homo sapiens Q14980
Y2H
12080061
Intra
TNKS2 Q9H2K2 NUMA1 Homo sapiens Q14980
Pull Down
12080061
Intra
TNKS2 Q9H2K2 NUMA1 Homo sapiens Q14980
FPS
22153077
Intra
TNKS2 Q9H2K2 DISC1 Homo sapiens Q9NRI5
FPS
22153077
Cross
TNKS2 Q9H2K2 Sh3bp2 Mus musculus Q06649
Anti Tag CoIP
22153076
Cross
TNKS2 Q9H2K2 Sh3bp2 Mus musculus Q06649
Pull Down
22153076
Cross
TNKS2 Q9H2K2 Sh3bp2 Mus musculus Q06649
Pull Down
22153077
Intra
TNKS2 Q9H2K2 CACNA1S Homo sapiens Q13698
FPS
22153077
Intra
TNKS2 Q9H2K2 CACNA1S Homo sapiens Q13698
Y2H
12080061
Intra
TNKS2 Q9H2K2 HOXB2 Homo sapiens P14652
Y2H
12080061
Intra
TNKS2 Q9H2K2 HOXB2 Homo sapiens P14652
FPS
22153077
Intra
TNKS2 Q9H2K2 RAD54L Homo sapiens Q92698
Pull Down
22153077
Intra
TNKS2 Q9H2K2 AXIN1 Homo sapiens O15169
FPS
22153077
Intra
TNKS2 Q9H2K2 TERF1 Homo sapiens P54274
FPS
22153077
Intra
TNKS2 Q9H2K2 TERF1 Homo sapiens P54274
Pull Down
22153077
Intra
TNKS2 Q9H2K2 TERF1 Homo sapiens P54274
Pull Down
12080061
Intra
TNKS2 Q9H2K2 BCR Homo sapiens P11274
Anti Tag CoIP
22153077
Intra
TNKS2 Q9H2K2 BCR Homo sapiens P11274
Pull Down
22153077
Intra
TNKS2 Q9H2K2 PPP1R12C Homo sapiens Q9BZL4
Y2H
12080061
Intra
TNKS2 Q9H2K2 PPP1R12C Homo sapiens Q9BZL4
FPS
22153077
Intra
TNKS2 Q9H2K2 SH3BP2 Homo sapiens P78314
FPS
22153077
Intra
TNKS2 Q9H2K2 SH3BP2 Homo sapiens P78314
Anti Bait CoIP
22153076
Intra
TNKS2 Q9H2K2 HIF1AN Homo sapiens Q9NWT6
Enzymatic Study
21251231
Intra
TNKS2 Q9H2K2 HIF1AN Homo sapiens Q9NWT6
X-Ray Diffraction
21251231
Intra
TNKS2 Q9H2K2 BABAM1 Homo sapiens Q9NWV8
Pull Down
22153077
Intra
TNKS2 Q9H2K2 FAT4 Homo sapiens Q6V0I7
FPS
22153077
Cross: Cross-species interaction Intra: Intraspecies interaction

TNKS2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P87124 Tankyrase 2 Antibody (YA6817) WB, ICC/IF Human, Rat

Related Diseases

Diseases Alias
Cherubism

  • CRBM

  • Familial Benign Giant-Cell Tumor Of The Jaw

  • Familial Fibrous Dysplasia Of Jaw

  • Familial Multilocular Cystic Disease Of The Jaws
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-12418 Stenoparib Inhibitor 98.0% Phase 2
HY-147245 Basroparib Inhibitor 98.91% Phase 1

Pre-clinical Phase

Bioactive Molecules (45)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15147 XAV-939 Inhibitor 99.91% Unkown
HY-16910 WIKI4 Inhibitor 99.93% Unkown
HY-13990 NVP-TNKS656 99.68% Unkown
HY-12438 G007-LK Inhibitor 99.24% Unkown
HY-145267 OM-153 Inhibitor 99.30% Unkown
HY-123851 MSC2504877 Inhibitor 99.25% Unkown
HY-12975 AZ6102 Inhibitor 99.53% Unkown
HY-148065 FMF-06-098-1 Inhibitor 98.77% Unkown
HY-15811 XMD8-87 Inhibitor 99.57% Unkown
HY-19351 MN-64 Inhibitor 99.61% Unkown
HY-101243 XMD16-5 Inhibitor 98.20% Unkown
HY-148061 DB1113 99.86% Unkown
HY-U00422 K-756 Inhibitor 99.25% Unkown
HY-148063 DB0614 99.92% Unkown
HY-126248 Tankyrase-IN-2 99.06% Unkown
HY-147886 PARP1-IN-11 Inhibitor 99.42% Unkown
HY-121719 TIQ-A Inhibitor 99.85% Unkown
HY-156332 TNKS-2-IN-2 Inhibitor 99.47% Unkown
HY-164478 G-631 Inhibitor 99.88% Unkown
HY-12577 TNKS1/2-IN-1 Inhibitor 99.24% Unkown
HY-143338 ART-IN-1 Inhibitor 98.91% Unkown
HY-146336 PARP1/2/TNKS1/2-IN-1 98.66% Unkown
HY-173349 TDI-012804 Inhibitor / Unkown
HY-23338 TNKS-2-IN-1 Inhibitor 95.03% Unkown
HY-100847 AZ0108 Inhibitor / Unkown
HY-114943 TNKS-IN-1 Inhibitor 99.55% Unkown
HY-12601 TNKS 22 Inhibitor / Unkown
HY-12602 TNKS-IN-4 Inhibitor / Unkown
HY-13990G NVP-TNKS656 (GMP) / Unkown
HY-145111 TNK2-IN-1 Inhibitor / Unkown
HY-145266 OM-1700 Inhibitor / Unkown
HY-153259 TNKS1/2-IN-2 Inhibitor / Unkown
HY-167762 TNKS-2-IN-4 Inhibitor / Unkown
HY-172747 TNKS-2-IN-3 Inhibitor / Unkown
HY-180926 PARP10-IN-4 Inhibitor / Unkown
HY-E70868 TNK1 Recombinant Human Active Protein Kinase / Unkown
HY-RS14838 TNK2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14843 TNKS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14844 Tnks2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14845 TNKS2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-153332 Tankyrase-IN-5 Inhibitor / Unkown
HY-168925 EXQ-2d Inhibitor / Unkown
HY-173480 TNKS-IN-3 Inhibitor / Unkown
HY-RS16928 Tnk2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23371 Tnk2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus TNKS2 VGNC VGNC:66423
Bos taurus TNKS2 VGNC VGNC:36186
Mus musculus TNKS2 MGD MGI:1921743
Rattus norvegicus TNKS2 RGD RGD:1305026
Canis familiaris TNKS2 VGNC VGNC:47683
Macaca mulatta TNKS2 VGNC VGNC:78983
Others TNKS2 NCBI