AXIN1 - axin 1 Gene
Also Known as AXIN; PPP1R49
Species: Homo sapiens
About AXIN1
This gene has 5 transcripts (splice variants), 274 orthologues, 23 paralogues and is associated with 102 phenotypes. Ubiquitous expression in bone marrow (RPKM 4.6), colon (RPKM 4.0) and 25 other tissues.
Summary
This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin beta-1, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (Wnt) signaling pathway and can induce Apoptosis. The crystal structure of a portion of this protein, alone and in a complex with Other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
AXIN1 Products (2)
| mRNA | Protein | Name |
|---|---|---|
| NM_003502.4 | NP_003493.1 | axin-1 isoform a |
| NM_181050.3 | NP_851393.1 | axin-1 isoform b |
AXIN1 Protein Structure
RGS: Regulator of G protein signaling domain (88 - 210)
Axin_b-cat_bind: Axin beta-catenin binding domain (464 - 495)
DIX: DIX domain (781 - 862)
- 0
- 200
- 400
- 600
- 800
- 862 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
axin-1 |
|
AXIN1 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
AXIN1 | O15169 | KRT40 | Homo sapiens | Q6A162 | 26871637 | |
|
Intra
|
AXIN1 | O15169 | KRT40 | Homo sapiens | Q6A162 | 26871637 | |
|
Intra
|
AXIN1 | O15169 | KRT40 | Homo sapiens | Q6A162 | 26871637 | |
|
Intra
|
AXIN1 | O15169 | KRTAP4-2 | Homo sapiens | Q9BYR5 | 26871637 | |
|
Intra
|
AXIN1 | O15169 | KRTAP4-2 | Homo sapiens | Q9BYR5 | 26871637 | |
|
Intra
|
AXIN1 | O15169 | KRTAP4-2 | Homo sapiens | Q9BYR5 | 26871637 | |
|
Intra
|
AXIN1 | O15169 | MID2 | Homo sapiens | Q9UJV3-2 | 26871637 | |
|
Intra
|
AXIN1 | O15169 | MID2 | Homo sapiens | Q9UJV3-2 | 26871637 | |
|
Intra
|
AXIN1 | O15169 | MID2 | Homo sapiens | Q9UJV3-2 | 26871637 | |
|
Intra
|
AXIN1 | O15169 | SUMO1P1 | Homo sapiens | G2XKQ0 | 26871637 | |
|
Intra
|
AXIN1 | O15169 | SUMO1P1 | Homo sapiens | G2XKQ0 | 26871637 | |
|
Intra
|
AXIN1 | O15169 | SUMO1P1 | Homo sapiens | G2XKQ0 | 26871637 | |
|
Intra
|
AXIN1 | O15169 | ZFYVE19 | Homo sapiens | Q96K21-3 | 26871637 | |
|
Intra
|
AXIN1 | O15169 | ZFYVE19 | Homo sapiens | Q96K21-3 | 26871637 | |
|
Intra
|
AXIN1 | O15169 | ZFYVE19 | Homo sapiens | Q96K21-3 | 26871637 | |
|
Intra
|
AXIN1 | O15169 | YAP1 | Homo sapiens | P46937 | 24976009 | |
|
Intra
|
AXIN1 | O15169 | GSK3A | Homo sapiens | P49840 | 17510365 | |
|
Intra
|
AXIN1 | O15169 | WDR26 | Homo sapiens | Q9H7D7 | 17510365 | |
|
Intra
|
AXIN1 | O15169 | PSTPIP1 | Homo sapiens | O43586 | 26871637 | |
|
Intra
|
AXIN1 | O15169 | PSTPIP1 | Homo sapiens | O43586 | 26871637 | |
|
Intra
|
AXIN1 | O15169 | PSTPIP1 | Homo sapiens | O43586 | 26871637 | |
|
Intra
|
AXIN1 | O15169 | CCDC57 | Homo sapiens | Q2TAC2-2 | 26871637 | |
|
Intra
|
AXIN1 | O15169 | CCDC57 | Homo sapiens | Q2TAC2-2 | 26871637 | |
|
Intra
|
AXIN1 | O15169 | CCDC57 | Homo sapiens | Q2TAC2-2 | 26871637 | |
|
Intra
|
AXIN1 | O15169 | TFIP11 | Homo sapiens | Q9UBB9 | 26871637 | |
|
Intra
|
AXIN1 | O15169 | TFIP11 | Homo sapiens | Q9UBB9 | 26871637 | |
|
Intra
|
AXIN1 | O15169 | TFIP11 | Homo sapiens | Q9UBB9 | 26871637 | |
|
Intra
|
AXIN1 | O15169 | MTUS2 | Homo sapiens | Q5JR59-3 | 26871637 | |
|
Intra
|
AXIN1 | O15169 | MTUS2 | Homo sapiens | Q5JR59-3 | 26871637 | |
|
Intra
|
AXIN1 | O15169 | MTUS2 | Homo sapiens | Q5JR59-3 | 26871637 | |
|
Intra
|
AXIN1 | O15169 | CARD9 | Homo sapiens | Q9H257-2 | 26871637 | |
|
Intra
|
AXIN1 | O15169 | CARD9 | Homo sapiens | Q9H257-2 | 26871637 | |
|
Intra
|
AXIN1 | O15169 | CARD9 | Homo sapiens | Q9H257-2 | 26871637 | |
|
Intra
|
AXIN1 | O15169 | SCYL1 | Homo sapiens | Q96KG9-4 | 26871637 | |
|
Intra
|
AXIN1 | O15169 | SCYL1 | Homo sapiens | Q96KG9-4 | 26871637 | |
|
Intra
|
AXIN1 | O15169 | SCYL1 | Homo sapiens | Q96KG9-4 | 26871637 | |
|
Intra
|
AXIN1 | O15169 | MEOX2 | Homo sapiens | Q6FHY5 | 26871637 | |
|
Intra
|
AXIN1 | O15169 | MEOX2 | Homo sapiens | Q6FHY5 | 26871637 | |
|
Intra
|
AXIN1 | O15169 | MEOX2 | Homo sapiens | Q6FHY5 | 26871637 | |
|
Intra
|
AXIN1 | O15169 | TRIM15 | Homo sapiens | Q9C019 | 26871637 | |
|
Intra
|
AXIN1 | O15169 | TRIM15 | Homo sapiens | Q9C019 | 26871637 | |
|
Intra
|
AXIN1 | O15169 | TRIM15 | Homo sapiens | Q9C019 | 26871637 | |
|
Intra
|
AXIN1 | O15169 | LHX4 | Homo sapiens | Q969G2 | 26871637 | |
|
Intra
|
AXIN1 | O15169 | LHX4 | Homo sapiens | Q969G2 | 26871637 | |
|
Intra
|
AXIN1 | O15169 | LHX4 | Homo sapiens | Q969G2 | 26871637 | |
|
Intra
|
AXIN1 | O15169 | FBXW11 | Homo sapiens | Q9UKB1 | 22682247 | |
|
Intra
|
AXIN1 | O15169 | FBXW11 | Homo sapiens | Q9UKB1 | 22682247 | |
|
Intra
|
AXIN1 | O15169 | TRAF2 | Homo sapiens | Q12933 | 26871637 | |
|
Intra
|
AXIN1 | O15169 | TRAF2 | Homo sapiens | Q12933 | 26871637 | |
|
Intra
|
AXIN1 | O15169 | TRAF2 | Homo sapiens | Q12933 | 26871637 | |
|
Intra
|
AXIN1 | O15169 | ANP32A | Homo sapiens | P39687 | 16169070 | |
|
Intra
|
AXIN1 | O15169 | ANP32A | Homo sapiens | P39687 | 16169070 | |
|
Intra
|
AXIN1 | O15169 | TP53 | Homo sapiens | P04637 | 21057547 | |
|
Intra
|
AXIN1 | O15169 | GSK3B | Homo sapiens | P49841 | 19202075 | |
|
Intra
|
AXIN1 | O15169 | GSK3B | Homo sapiens | P49841 | 17510365 | |
|
Intra
|
AXIN1 | O15169 | GSK3B | Homo sapiens | P49841 | 22682247 | |
|
Intra
|
AXIN1 | O15169 | GSK3B | Homo sapiens | P49841 | 11738041 | |
|
Intra
|
AXIN1 | O15169 | GSK3B | Homo sapiens | P49841 | 21988832 | |
|
Intra
|
AXIN1 | O15169 | GSK3B | Homo sapiens | P49841 | 19303846 | |
|
Intra
|
AXIN1 | O15169 | GSK3B | Homo sapiens | P49841 | 22682247 | |
|
Intra
|
AXIN1 | O15169 | GSK3B | Homo sapiens | P49841 | 19131971 | |
|
Intra
|
AXIN1 | O15169 | GSK3B | Homo sapiens | P49841 | 17601533 | |
|
Intra
|
AXIN1 | O15169 | GSK3B | Homo sapiens | P49841 | 17318191 | |
|
Intra
|
AXIN1 | O15169 | GSK3B | Homo sapiens | P49841 | 21242974 | |
|
Intra
|
AXIN1 | O15169 | SMAD7 | Homo sapiens | O15105 | 16601693 | |
|
Intra
|
AXIN1 | O15169 | ZBTB26 | Homo sapiens | Q9HCK0 | 26871637 | |
|
Intra
|
AXIN1 | O15169 | ZBTB26 | Homo sapiens | Q9HCK0 | 26871637 | |
|
Intra
|
AXIN1 | O15169 | ZBTB26 | Homo sapiens | Q9HCK0 | 26871637 | |
|
Cross
|
AXIN1 | O15169 | Ctnnb1 | Mus musculus | Q02248 | 16293619 | |
|
Intra
|
AXIN1 | O15169 | MYC | Homo sapiens | P01106 | 19131971 | |
|
Intra
|
AXIN1 | O15169 | CRMP1 | Homo sapiens | Q14194 | 16169070 | |
|
Intra
|
AXIN1 | O15169 | CRMP1 | Homo sapiens | Q14194 | 16169070 | |
|
Intra
|
AXIN1 | O15169 | CTNNB1 | Homo sapiens | P35222 | 22682247 | |
|
Intra
|
AXIN1 | O15169 | CTNNB1 | Homo sapiens | P35222 | 19166851 | |
|
Intra
|
AXIN1 | O15169 | CTNNB1 | Homo sapiens | P35222 | 22773187 | |
|
Intra
|
AXIN1 | O15169 | CTNNB1 | Homo sapiens | P35222 | 22682247 | |
|
Intra
|
AXIN1 | O15169 | CTNNB1 | Homo sapiens | P35222 | 22773187 | |
|
Intra
|
AXIN1 | O15169 | CTNNB1 | Homo sapiens | P35222 | 17510365 | |
|
Intra
|
AXIN1 | O15169 | CTNNB1 | Homo sapiens | P35222 | 17318191 | |
|
Intra
|
AXIN1 | O15169 | CTNNB1 | Homo sapiens | P35222 | 17318191 | |
|
Intra
|
AXIN1 | O15169 | CTNNB1 | Homo sapiens | P35222 | 21242974 | |
|
Intra
|
AXIN1 | O15169 | SPRED1 | Homo sapiens | Q7Z699 | 32814053 | |
|
Intra
|
AXIN1 | O15169 | SPRED1 | Homo sapiens | Q7Z699 | 32814053 | |
|
Intra
|
AXIN1 | O15169 | SPRED1 | Homo sapiens | Q7Z699 | 32814053 | |
|
Intra
|
AXIN1 | O15169 | AMER1 | Homo sapiens | Q5JTC6 | 26496610 | |
|
Intra
|
AXIN1 | O15169 | AMER1 | Homo sapiens | Q5JTC6 | 22682247 | |
|
Intra
|
AXIN1 | O15169 | AMER1 | Homo sapiens | Q5JTC6 | 17510365 | |
|
Intra
|
AXIN1 | O15169 | GOLGA2 | Homo sapiens | Q08379 | 26871637 | |
|
Intra
|
AXIN1 | O15169 | GOLGA2 | Homo sapiens | Q08379 | 26871637 | |
|
Intra
|
AXIN1 | O15169 | GOLGA2 | Homo sapiens | Q08379 | 26871637 | |
|
Intra
|
AXIN1 | O15169 | TRIM29 | Homo sapiens | Q14134 | 19249679 | |
|
Intra
|
AXIN1 | O15169 | JUP | Homo sapiens | P14923 | 26871637 | |
|
Intra
|
AXIN1 | O15169 | JUP | Homo sapiens | P14923 | 26871637 | |
|
Intra
|
AXIN1 | O15169 | JUP | Homo sapiens | P14923 | 26496610 | |
|
Intra
|
AXIN1 | O15169 | JUP | Homo sapiens | P14923 | 26871637 | |
|
Intra
|
AXIN1 | O15169 | STX11 | Homo sapiens | O75558 | 26871637 | |
|
Intra
|
AXIN1 | O15169 | STX11 | Homo sapiens | O75558 | 26871637 | |
|
Intra
|
AXIN1 | O15169 | STX11 | Homo sapiens | O75558 | 26871637 | |
|
Intra
|
AXIN1 | O15169 | TRIM27 | Homo sapiens | P14373 | 26871637 | |
|
Intra
|
AXIN1 | O15169 | TRIM27 | Homo sapiens | P14373 | 26871637 | |
|
Intra
|
AXIN1 | O15169 | TRIM27 | Homo sapiens | P14373 | 26871637 | |
|
Intra
|
AXIN1 | O15169 | MDFI | Homo sapiens | Q99750 | 26871637 | |
|
Intra
|
AXIN1 | O15169 | MDFI | Homo sapiens | Q99750 | 26871637 | |
|
Intra
|
AXIN1 | O15169 | MDFI | Homo sapiens | Q99750 | 26871637 | |
|
Intra
|
AXIN1 | O15169 | APC | Homo sapiens | P25054 | 10811618 | |
|
Intra
|
AXIN1 | O15169 | APC | Homo sapiens | P25054 | 22682247 | |
|
Intra
|
AXIN1 | O15169 | APC | Homo sapiens | P25054 | 26496610 | |
|
Intra
|
AXIN1 | O15169 | APC | Homo sapiens | P25054 | 10811618 | |
|
Intra
|
AXIN1 | O15169 | APC | Homo sapiens | P25054 | 19131971 | |
|
Intra
|
AXIN1 | O15169 | APC | Homo sapiens | P25054 | 17510365 | |
|
Intra
|
AXIN1 | O15169 | CALCOCO2 | Homo sapiens | Q13137 | 26871637 | |
|
Intra
|
AXIN1 | O15169 | CALCOCO2 | Homo sapiens | Q13137 | 26871637 | |
|
Intra
|
AXIN1 | O15169 | CALCOCO2 | Homo sapiens | Q13137 | 26871637 | |
|
Intra
|
AXIN1 | O15169 | KRTAP4-12 | Homo sapiens | Q9BQ66 | 26871637 | |
|
Intra
|
AXIN1 | O15169 | KRTAP4-12 | Homo sapiens | Q9BQ66 | 26871637 | |
|
Intra
|
AXIN1 | O15169 | KRTAP4-12 | Homo sapiens | Q9BQ66 | 26871637 | |
|
Intra
|
AXIN1 | O15169 | DVL2 | Homo sapiens | O14641 | 21245303 | |
|
Intra
|
AXIN1 | O15169 | TRIM37 | Homo sapiens | O94972 | 26871637 | |
|
Intra
|
AXIN1 | O15169 | TRIM37 | Homo sapiens | O94972 | 26871637 | |
|
Intra
|
AXIN1 | O15169 | TRIM37 | Homo sapiens | O94972 | 26871637 | |
|
Intra
|
AXIN1 | O15169 | TRIP6 | Homo sapiens | Q15654 | 26871637 | |
|
Intra
|
AXIN1 | O15169 | TRIP6 | Homo sapiens | Q15654 | 26871637 | |
|
Intra
|
AXIN1 | O15169 | TRIP6 | Homo sapiens | Q15654 | 26871637 | |
|
Intra
|
AXIN1 | O15169 | ARRB1 | Homo sapiens | P49407 | 19202075 | |
|
Intra
|
AXIN1 | O15169 | CSNK1E | Homo sapiens | P49674 | 26496610 | |
|
Intra
|
AXIN1 | O15169 | CSNK1E | Homo sapiens | P49674 | 22682247 | |
|
Intra
|
AXIN1 | O15169 | SUMO1 | Homo sapiens | P63165 | 26871637 | |
|
Intra
|
AXIN1 | O15169 | SUMO1 | Homo sapiens | P63165 | 26871637 | |
|
Intra
|
AXIN1 | O15169 | SUMO1 | Homo sapiens | P63165 | 26871637 | |
|
Cross
|
AXIN1 | O15169 | GSK3B | Oryctolagus cuniculus | G1T8E2 | 10481074 | |
|
Cross
|
AXIN1 | O15169 | apc | Crosspus laevis | P70039 | 18786926 |
AXIN1 Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P83825 | AXIN1 Antibody (YA3522) | ICC/IF, FC, ELISA | Human |
| HY-P83825A | AXIN1 Antibody (YA3522)(PBS only) | ICC/IF, FC, ELISA | Human |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Caudal Duplication Anomaly |
|
|
| Hepatocellular Carcinoma |
|
|
| Adult Hepatocellular Carcinoma |
|
|
| Familial Adenomatous Polyposis |
|
|
| Cherubism |
|
|
| Pulmonary Sclerosing Hemangioma |
|
|
| Medulloblastoma |
|
|
| Colorectal Cancer |
|
|
| Arthrogryposis, Renal Dysfunction, And Cholestasis 1 |
|
|
| Enterobiasis |
|
|
| Endometrial Cancer |
|
|
| Hair Follicle Neoplasm |
|
|
| Adult Liposarcoma |
|
|
| Ovarian Cancer |
|
|
| Brain Cancer |
|
|
| Osteoporosis-Pseudoglioma Syndrome |
|
|
| Desmoid Tumor |
|
|
| Colorectal Cancer, Hereditary Nonpolyposis, Type 5 |
|
|
| Pilomatrixoma |
|
|
| Glioblastoma |
|
|
| Breast Cancer |
|
|
| Hemochromatosis, Type 1 |
|
|
| Liver Benign Neoplasm |
|
|
| Intestinal Benign Neoplasm |
|
|
| Encephalopathy, Neonatal Severe, Due To Mecp2 Mutations |
|
|
| Osteoporosis |
|
|
| Prostate Cancer |
|
|
| Colonic Benign Neoplasm |
|
|
| Exudative Vitreoretinopathy |
|
|
| Lymphangioma |
|
|
| Tooth Agenesis |
|
|
| Lynch Syndrome |
|
|
| Wilms Tumor 1 |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Mus musculus | AXIN1 | MGD | MGI:1096327 |
| Macaca mulatta | AXIN1 | VGNC | VGNC:70199 |
| Felis catus | AXIN1 | VGNC | VGNC:68879 |
| Bos taurus | AXIN1 | VGNC | VGNC:26364 |
| Canis familiaris | AXIN1 | VGNC | VGNC:38324 |
| Rattus norvegicus | AXIN1 | RGD | RGD:620859 |
| Others | AXIN1 | NCBI |