TRIM15 - tripartite motif containing 15 Gene

Also Known as RNF93; ZNFB7; ZNF178

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 89870

About TRIM15

This gene has 4 transcripts (splice variants), 1 gene allele, 79 orthologues and 80 paralogues. Biased expression in duodenum (RPKM 12.6), small intestine (RPKM 9.2) and 6 other tissues.

Summary

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to the cytoplasm. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

TRIM15 Products (1)

mRNA	Protein	Name
NM_033229.3	NP_150232.2	tripartite motif-containing protein 15

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables molecular sequestering activity	IDA IDA: Inferred from direct assay	34871740	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	23077300	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in innate immune response	IMP IMP: Inferred from mutant phenotype	18248090	GOA
involved in negative regulation of intracellular transport of viral material	IMP IMP: Inferred from mutant phenotype	18248090	GOA
involved in negative regulation of non-canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	34871740	GOA
involved in positive regulation of DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	23077300	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IDA IDA: Inferred from direct assay	23077300	GOA
involved in positive regulation of RIG-I signaling pathway	IMP IMP: Inferred from mutant phenotype	23077300	GOA
involved in positive regulation of type I interferon production	IMP IMP: Inferred from mutant phenotype	23077300	GOA
involved in suppression of viral release by host	IDA IDA: Inferred from direct assay	18248090	GOA
involved in suppression of viral release by host	IMP IMP: Inferred from mutant phenotype	18248090	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in nucleus	IDA IDA: Inferred from direct assay	34871740	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRIM15 Protein Structure

zf-C3HC4

zf-B_box

0
100
115 a.a.

Protein Preferred Names	Protein Names
tripartite motif-containing protein 15	RING finger protein 93

TRIM15 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TRIM15	Q9C019	FAM161A	Homo sapiens	Q3B820	Y2H Prey Pooling	25416956
Intra	TRIM15	Q9C019	FAM161A	Homo sapiens	Q3B820	Validated Y2H	25416956
Intra	TRIM15	Q9C019	FAM151B	Homo sapiens	Q6UXP7	Y2H Array	25416956
Intra	TRIM15	Q9C019	RABGEF1	Homo sapiens	Q9UJ41	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15023	TRIM15 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20198	Trim15 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TRIM15	VGNC	VGNC:36316
Mus musculus	TRIM15	MGD	MGI:1916347
Macaca mulatta	TRIM15	VGNC	VGNC:83958
Rattus norvegicus	TRIM15	RGD	RGD:6496746
Others	TRIM15	NCBI