GSK3A - glycogen synthase kinase 3 alpha Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2931

About GSK3A

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:42,230,190-42,242,602 (from NCBI)

This gene has 40 transcripts (splice variants), 260 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 26.3), testis (RPKM 18.3) and 25 other tissues.

Summary

This gene encodes a multifunctional Ser/Thr protein kinase that is implicated in the control of several regulatory proteins including glycogen synthase, and transcription factors, such as JUN. It also plays a role in the Wnt and PI3K signaling pathways, as well as regulates the production of beta-amyloid peptides associated with Alzheimer's disease. [provided by RefSeq, Oct 2011]

GSK3A Products (2)

mRNA	Protein	Name
NM_019884.3	NP_063937.2	glycogen synthase kinase-3 alpha
XR_001753673.2

GSK3A Protein Structure

Pkinase

0
100
200
300
400
483 a.a.

Protein Preferred Names	Protein Names
glycogen synthase kinase-3 alpha	GSK-3 alpha serine/threonine-protein kinase GSK3A

GSK3A Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	GSK3A	P49840	GSKIP	Homo sapiens	Q9P0R6	Anti Tag CoIP	35271311
Intra	GSK3A	P49840	GSKIP	Homo sapiens	Q9P0R6	TAP	23602568
Intra	GSK3A	P49840	FBXO42	Homo sapiens	Q6P3S6	Y2H	30824926
Intra	GSK3A	P49840	HSP90AB1	Homo sapiens	P08238	Y2H	30824926
Intra	GSK3A	P49840	YWHAE	Homo sapiens	P62258	Crosslink	36931259
Intra	GSK3A	P49840	MAPT	Homo sapiens	P10636-8	Protein Kinase Assay	26618561
Intra	GSK3A	P49840	FRAT1	Homo sapiens	Q92837	Anti Tag CoIP	33961781
Intra	GSK3A	P49840	FRAT1	Homo sapiens	Q92837	TAP	23602568
Intra	GSK3A	P49840	AXIN2	Homo sapiens	Q9Y2T1	TAP	23602568
Intra	GSK3A	P49840	AXIN2	Homo sapiens	Q9Y2T1	Y2H	30824926
Intra	GSK3A	P49840	AXIN2	Homo sapiens	Q9Y2T1	Anti Tag CoIP	33961781
Intra	GSK3A	P49840	ZDHHC17	Homo sapiens	Q8IUH5	Y2H Array	24705354
Intra	GSK3A	P49840	ZDHHC17	Homo sapiens	Q8IUH5	Lumier	24705354
Intra	GSK3A	P49840	AXIN1	Homo sapiens	O15169	Anti Tag CoIP	33961781
Intra	GSK3A	P49840	AXIN1	Homo sapiens	O15169	TAP	23602568
Intra	GSK3A	P49840	AXIN1	Homo sapiens	O15169	Anti Tag CoIP	17318175
Intra	GSK3A	P49840	AXIN1	Homo sapiens	O15169	Anti Tag CoIP	35271311
Intra	GSK3A	P49840	DEAF1	Homo sapiens	O75398	Y2H	30824926
Intra	GSK3A	P49840	DEAF1	Homo sapiens	O75398	Protein Kinase Assay	20368287
Intra	GSK3A	P49840	NBR1	Homo sapiens	Q14596	Anti Tag CoIP	33961781
Intra	GSK3A	P49840	NBR1	Homo sapiens	Q14596	Pull Down	24879152
Intra	GSK3A	P49840	NBR1	Homo sapiens	Q14596	Y2H	30824926
Intra	GSK3A	P49840	NBR1	Homo sapiens	Q14596	Protein Kinase Assay	24879152
Intra	GSK3A	P49840	LRP6	Homo sapiens	O75581	Y2H	30824926
Intra	GSK3A	P49840	LRP6	Homo sapiens	O75581	Pull Down	16365045
Intra	GSK3A	P49840	LRP6	Homo sapiens	O75581	Anti Tag CoIP	16365045

Cross: Cross-species interaction Intra: Intraspecies interaction

GSK3A Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80497	GSK3 beta Antibody (YA397)	WB, ICC/IF, IHC-P, FC	Human, Mouse, Rat
HY-P80819	Phospho-GSK3 (Tyr216/Tyr279) Antibody (YA194)	WB, IP	Mouse, Rat
HY-P80819A	Phospho-GSK3 (Tyr216/Tyr279) Antibody (YA194)(PBS only)	WB, IP	Mouse, Rat
HY-P810582	Phospho-GSK3 (alpha + beta) (Tyr216 + Y279) Antibody (YA9846)	WB, ICC/IF, IHC-P, IP, IF-Tissue, FC	Human, Mouse, Rat
HY-P810583	Phospho-GSK3 alpha (Ser21) Antibody (YA9847)	WB, IHC-P, Dot Blot	Human, Mouse
HY-P82117	GSK3 alpha/beta Antibody (YA1862)	WB	Human, Rat, Hamster
HY-P82117A	GSK3 alpha/beta Antibody (YA1862)(PBS only)	WB	Human, Rat, Hamster
HY-P83226	GSK3 alpha Antibody (YA2971)	WB, ICC/IF, IP	Human, Mouse, Rat
HY-P83226A	GSK3 alpha Antibody (YA2971)(PBS only)	WB, ICC/IF, IP	Human, Mouse, Rat
HY-P84358	GSK3 alpha Antibody (YA4055)	WB, ICC/IF, ELISA	Human
HY-P84358A	GSK3 alpha Antibody (YA4055)(PBS only)	WB, ICC/IF, ELISA	Human
HY-P85194	GSK3 alpha Antibody (YA4886)	WB, IHC-P, ICC/IF, ELISA	Human
HY-P85874	GSK3 alpha+beta Antibody (YA5566)	WB, ICC/IF, ELISA	Human, Mouse, Rat
HY-P86164	Phospho-GSK3 alpha+beta(Tyr216/Tyr279) (YA5856)	WB, IHC-P, ICC/IF	Human, Mouse, Rat
HY-P86437	GSK3 alpha+beta Antibody (YA6129)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
HY-P86484	GSK3 alpha Antibody (YA6176)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Pancreatic Cancer	Pancreatic Carcinoma Familial Pancreatic Carcinoma Pancreatic Neoplasm Carcinoma Of Pancreas Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Cancer Of The Pancreas Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-136848	SM1-71	Inhibitor	96.09%	Unkown
HY-W969907	GSK3-IN-7		99.35%	Unkown
HY-122665	HTH-01-091	Inhibitor	99.81%	Unkown
HY-122665A	HTH-01-091 TFA	Inhibitor	99.48%	Unkown
HY-RS05862	GSK3A Human Pre-designed siRNA Set A		/	Unkown
HY-RS05863	Gsk3a Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS05864	Gsk3a Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	GSK3A	RGD	RGD:620351
Mus musculus	GSK3A	MGD	MGI:2152453
Canis familiaris	GSK3A	VGNC	VGNC:101443
Bos taurus	GSK3A	VGNC	VGNC:101449
Felis catus	GSK3A	VGNC	VGNC:101459
Others	GSK3A	NCBI