FBXO42 - F-box protein 42 Gene

Also Known as JFK; Fbx42

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 54455

About FBXO42

Cytogenetic location: 1p36.13 Genomic coordinates (GRCh38): 1:16,246,840-16,352,480 (from NCBI)

This gene has 4 transcripts (splice variants), 212 orthologues and 10 paralogues. Ubiquitous expression in skin (RPKM 6.4), fat (RPKM 5.1) and 25 other tissues.

Summary

Members of the F-box protein family, such as FBXO42, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (SKP1A; MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through Other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Dec 2010]

FBXO42 Products (1)

mRNA	Protein	Name
NM_018994.3	NP_061867.1	F-box only protein 42

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25609649	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FBXO42 Protein Structure

F-box-like

Kelch_3

Kelch_2

0
200
400
600
717 a.a.

Protein Preferred Names	Protein Names
F-box only protein 42	just one F-box and Kelch domain-containing protein

FBXO42 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	FBXO42	Q6P3S6	GSK3A	Homo sapiens	P49840	Anti Tag CoIP	33961781
Intra	FBXO42	Q6P3S6	GSK3A	Homo sapiens	P49840	Anti Tag CoIP	28514442
Intra	FBXO42	Q6P3S6	DNM2	Homo sapiens	P50570-2	Validated Y2H	32814053
Intra	FBXO42	Q6P3S6	DNM2	Homo sapiens	P50570-2	Y2H Array	32814053
Intra	FBXO42	Q6P3S6	DNM2	Homo sapiens	P50570-2	Y2H Pooling	32814053
Intra	FBXO42	Q6P3S6	TPP1	Homo sapiens	O14773	Validated Y2H	32814053
Intra	FBXO42	Q6P3S6	TPP1	Homo sapiens	O14773	Y2H Array	32814053
Intra	FBXO42	Q6P3S6	TPP1	Homo sapiens	O14773	Y2H Pooling	32814053
Intra	FBXO42	Q6P3S6	RBPJ	Homo sapiens	Q06330	Anti Tag CoIP	33961781
Intra	FBXO42	Q6P3S6	RBPJ	Homo sapiens	Q06330	TAP	25609649
Intra	FBXO42	Q6P3S6	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	FBXO42	Q6P3S6	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	FBXO42	Q6P3S6	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	FBXO42	Q6P3S6	NDUFV1	Homo sapiens	P49821	Validated Y2H	32814053
Intra	FBXO42	Q6P3S6	NDUFV1	Homo sapiens	P49821	Y2H Pooling	32814053
Intra	FBXO42	Q6P3S6	NDUFV1	Homo sapiens	P49821	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Desmoid Disease, Hereditary	Fif DESMD Hereditary Desmoid Disease Familial Infiltrative Fibromatosis Fibromatosis, Familial Infiltrative Fibromatosis, Aggressive
Parkinson Disease 15, Autosomal Recessive Early-Onset	Parkinsonian-Pyramidal Syndrome Pallidopyramidal Syndrome Parkinson Disease 15, Autosomal Recessive PARK15 Pkps Pallido-Pyramidal Syndrome Parkinson'S Disease 15 Autosomal Recessive Early-Onset Parkinson Disease 15 Autosomal Recessive Early-Onset Parkinson'S Disease 15 Pallido-Pyramidal Disease Parkinson Disease 15 Parkinson Disease 15 Autosomal Recessive Pps Parkinson Disease, Type 15

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04808	FBXO42 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	FBXO42	RGD	RGD:1304787
Macaca mulatta	FBXO42	VGNC	VGNC:72597
Mus musculus	FBXO42	MGD	MGI:1924992
Bos taurus	FBXO42	VGNC	VGNC:28913
Felis catus	FBXO42	VGNC	VGNC:62194
Canis familiaris	FBXO42	VGNC	VGNC:40782