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  3. GSKIP - GSK3B interacting protein Gene

GSKIP - GSK3B interacting protein Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as HSPC210; C14orf129

Gene ID: 51527 | Gene type: protein coding

About GSKIP

Cytogenetic location: 14q32.2 Genomic coordinates (GRCh38): 14:96,363,526-96,387,290 (from NCBI)

This gene has 7 transcripts (splice variants) and 209 orthologues. Broad expression in colon (RPKM 25.5), small intestine (RPKM 20.7) and 24 other tissues.

Summary

This gene encodes a protein that is involved as a negative regulator of GSK3-beta in the Wnt signaling pathway. The encoded protein may play a role in the retinoic acid signaling pathway by regulating the functional interactions between GSK3-beta, beta-catenin and cyclin D1, and it regulates the beta-catenin/N-Cadherin pool. The encoded protein contains a GSK3-beta interacting domain (GID) in its C-terminus, which is similar to the GID of Axin. The protein also contains an evolutionarily conserved RII-binding domain, which facilitates binding with protein kinase-A and GSK3-beta, enabling its role as an A-kinase anchoring protein. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2012]

GSKIP Products(4)

mRNA Protein Name
NM_001271904.1 NP_001258833.1 GSK3B-interacting protein
NM_001271905.2 NP_001258834.1 GSK3B-interacting protein
NM_001271906.2 NP_001258835.1 GSK3B-interacting protein
NM_016472.5 NP_057556.2 GSK3B-interacting protein

GSKIP Protein Structure

DUF727

DUF727: Protein of unknown function (DUF727) (32 - 134)

  • 0
  • 100
  • 139 a.a.
Protein Preferred Names Protein Names

GSK3B-interacting protein

GSK3-beta interaction protein

Related Diseases

Diseases Alias
Type 1 Diabetes Mellitus 20

Diabetes Mellitus, Insulin-Dependent, 20

IDDM20

T1D20

Insulin-Dependent Diabetes Mellitus 20

Diabetes Mellitus, Insulin-Dependent, Type 20
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05866 GSKIP Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus GSKIP VGNC VGNC:29679
Mus musculus GSKIP MGD MGI:1914037
Canis familiaris GSKIP VGNC VGNC:41531
Rattus norvegicus GSKIP RGD RGD:1308470
Felis catus GSKIP VGNC VGNC:80960
Macaca mulatta GSKIP VGNC VGNC:73202