FRAT1 - FRAT regulator of WNT signaling pathway 1 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10023

About FRAT1

Cytogenetic location: 10q24.1 Genomic coordinates (GRCh38): 10:97,319,271-97,321,915 (from NCBI)

This gene has 2 transcripts (splice variants), 63 orthologues and 1 paralogue.

Summary

The protein encoded by this gene belongs to the GSK-3-binding protein family. The protein inhibits GSK-3-mediated phosphorylation of beta-catenin and positively regulates the Wnt signaling pathway. It may function in tumor progression and in lymphomagenesis. [provided by RefSeq, Oct 2008]

FRAT1 Products (1)

mRNA Protein Name
NM_005479.4 NP_005470.2 proto-oncogene FRAT1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables molecular function inhibitor activity IDA
IDA: Inferred from direct assay
10481074 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
10481074 GOA
Biological Process GO Annotation Evidence References Source
involved in canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
10428961 GOA
involved in canonical Wnt signaling pathway IGI
IGI: Inferred from genetic interaction
12556519 GOA
involved in positive regulation of canonical Wnt signaling pathway IGI
IGI: Inferred from genetic interaction
12556519 GOA
involved in regulation of protein export from nucleus IDA
IDA: Inferred from direct assay
12223487 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
12223487 GOA
located in nucleus IDA
IDA: Inferred from direct assay
12223487 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FRAT1 Protein Structure

GSK-3_bind

GSK-3_bind: Glycogen synthase kinase-3 binding (1 - 239)

  • 0
  • 100
  • 200
  • 279 a.a.
Protein Preferred Names Protein Names

proto-oncogene FRAT1

  • FRAT-1

FRAT1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
FRAT1 Q92837 GSK3A Homo sapiens P49840
Pull Down
10481074
Intra
FRAT1 Q92837 GSK3A Homo sapiens P49840
Anti Tag CoIP
26496610
Intra
FRAT1 Q92837 GSK3B Homo sapiens P49841
X-Ray Diffraction
11738041
Intra
FRAT1 Q92837 GSK3B Homo sapiens P49841
Anti Tag CoIP
26496610
Cross: Cross-species interaction Intra: Intraspecies interaction

FRAT1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83118 FRAT1 Antibody (YA2863) WB, ICC/IF, IP Human
HY-P83118A FRAT1 Antibody (YA2863)(PBS only) WB, ICC/IF, IP Human

Related Diseases

Diseases Alias
Hepatocellular Carcinoma

  • Liver Cancer

  • Primary Liver Cancer

  • HCC

  • Hepatoma

  • Malignant Neoplasm Of Liver

  • Liver Neoplasms

  • Cancer, Hepatocellular

  • Liver Cell Carcinoma

  • Lcc

  • Hepatoblastoma, Somatic

  • Hepatic Cancer

  • Primary Malignant Neoplasm Of Liver

  • Rare Tumor Of Liver And Intrahepatic Biliary Tract

  • Hepatocellular Carcinoma, Somatic

  • Hepatocellular Carcinoma, Childhood Type, Somatic

  • Hepatocellular Cancer, Somatic

  • Ca Liver - Primary

  • Hepatic Neoplasm

  • Malignant Hepato-Biliary Neoplasm

  • Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

  • Malignant Neoplasm Of Liver, Primary

  • Malignant Tumor Of Liver

  • Neoplasm Of Liver

  • Non-Resectable Primary Hepatic Malignant Neoplasm

  • Resectable Malignant Neoplasm Of Liver

  • Resectable Malignant Neoplasm Of The Liver

  • Primary Liver Carcinoma

  • Primary Malignant Liver Neoplasm

  • Primary Cancer Of Liver

  • Primary Tumor Of The Liver

  • Rare Tumor Of Liver And Ibt

  • Hepatocellular Cancer

  • Neoplasm Of The Liver

  • Carcinoma, Hepatocellular

  • Hepatomas

  • Liver Neoplasm

  • Liver Carcinoma

  • Liver And Intrahepatic Biliary Tract Carcinoma

  • Malignant Hepatobiliary Neoplasm

  • Adult Primary Hepatocellular Carcinoma

  • Hepatoblastoma

  • Carcinoma Of Liver

  • Malignant Liver Tumour

  • Malignant Hepatic Tumour
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05090 FRAT1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta FRAT1 VGNC VGNC:72816
Mus musculus FRAT1 MGD MGI:109450
Bos taurus FRAT1 VGNC VGNC:55951
Rattus norvegicus FRAT1 RGD RGD:9147096
Others FRAT1 NCBI