LHX4 - LIM homeobox 4 Gene

Also Known as CPHD4

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 89884

About LHX4

Cytogenetic location: 1q25.2 Genomic coordinates (GRCh38): 1:180,228,375-180,278,984 (from NCBI)

This gene has 3 transcripts (splice variants), 213 orthologues, 20 paralogues and is associated with 6 phenotypes. Ubiquitous expression in testis (RPKM 1.2), placenta (RPKM 0.8) and 24 other tissues.

Summary

This gene encodes a member of a large protein family which contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor involved in the control of differentiation and development of the pituitary gland. Mutations in this gene cause combined pituitary hormone deficiency 4. [provided by RefSeq, Dec 2010]

LHX4 Products (1)

mRNA	Protein	Name
NM_033343.4	NP_203129.1	LIM/homeobox protein Lhx4

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	15998782	GOA
enables methyl-CpG binding	IDA IDA: Inferred from direct assay	28473536	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20211142	GOA
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15998782	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LHX4 Protein Structure

LIM

Homeobox

0
100
200
300
390 a.a.

Protein Preferred Names	Protein Names
LIM/homeobox protein Lhx4	LIM homeobox protein 4

LHX4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	LHX4	Q969G2	FDX2	Homo sapiens	Q6P4F2	Y2H Array	25416956
Intra	LHX4	Q969G2	FDX2	Homo sapiens	Q6P4F2	Y2H Prey Pooling	25416956
Intra	LHX4	Q969G2	LDB1	Homo sapiens	Q86U70-2	Anti Tag CoIP	28514442
Intra	LHX4	Q969G2	MRS2	Homo sapiens	Q9HD23-2	Validated Y2H	32296183
Intra	LHX4	Q969G2	PARP11	Homo sapiens	Q9NR21-1	Validated Y2H	32296183
Intra	LHX4	Q969G2	ISL2	Homo sapiens	Q96A47	Anti Tag CoIP	27820671
Intra	LHX4	Q969G2	ISL2	Homo sapiens	Q96A47	BioID	35140242
Intra	LHX4	Q969G2	ISL2	Homo sapiens	Q96A47	Affinity Chrom	35140242
Intra	LHX4	Q969G2	ISL2	Homo sapiens	Q96A47	Anti Tag CoIP	33961781
Intra	LHX4	Q969G2	ISL2	Homo sapiens	Q96A47	Anti Tag CoIP	28514442
Intra	LHX4	Q969G2	CHCHD2	Homo sapiens	Q9Y6H1	Y2H Prey Pooling	25416956
Intra	LHX4	Q969G2	LONRF1	Homo sapiens	Q17RB8	Validated Y2H	25416956
Intra	LHX4	Q969G2	ERO1A	Homo sapiens	Q96HE7	Validated Y2H	32296183
Intra	LHX4	Q969G2	TXNDC5	Homo sapiens	Q86UY0	Y2H Prey Pooling	25416956
Intra	LHX4	Q969G2	TXNDC5	Homo sapiens	Q86UY0	Validated Y2H	25416956
Intra	LHX4	Q969G2	TXNDC5	Homo sapiens	Q86UY0	Y2H Array	25416956
Intra	LHX4	Q969G2	CORO1B	Homo sapiens	Q9BR76	Validated Y2H	32296183
Intra	LHX4	Q969G2	ORC6	Homo sapiens	Q9Y5N6	Validated Y2H	32296183
Intra	LHX4	Q969G2	ORC6	Homo sapiens	Q9Y5N6	Y2H Array	25416956
Intra	LHX4	Q969G2	ORC6	Homo sapiens	Q9Y5N6	Y2H Prey Pooling	25416956
Intra	LHX4	Q969G2	ORC6	Homo sapiens	Q9Y5N6	Y2H Array	31515488
Intra	LHX4	Q969G2	ISL1	Homo sapiens	P61371	Anti Tag CoIP	28514442
Intra	LHX4	Q969G2	ISL1	Homo sapiens	P61371	Anti Tag CoIP	33961781
Intra	LHX4	Q969G2	SH2D1A	Homo sapiens	O60880	MAPPIT	25416956
Intra	LHX4	Q969G2	SH2D1A	Homo sapiens	O60880	Validated Y2H	25416956
Intra	LHX4	Q969G2	WASHC3	Homo sapiens	Q9Y3C0	Validated Y2H	32296183
Intra	LHX4	Q969G2	INO80B	Homo sapiens	Q9C086	Validated Y2H	32296183
Intra	LHX4	Q969G2	MAPRE3	Homo sapiens	Q9UPY8	Validated Y2H	32296183
Intra	LHX4	Q969G2	USP2	Homo sapiens	O75604	Y2H Prey Pooling	25416956
Intra	LHX4	Q969G2	USP2	Homo sapiens	O75604	Validated Y2H	25416956
Intra	LHX4	Q969G2	MYOZ1	Homo sapiens	Q9NP98	Validated Y2H	32296183
Intra	LHX4	Q969G2	DHRS1	Homo sapiens	Q96LJ7	Validated Y2H	32296183
Intra	LHX4	Q969G2	YY1	Homo sapiens	P25490	BioID	35140242
Intra	LHX4	Q969G2	SNRNP25	Homo sapiens	Q9BV90	Validated Y2H	25416956
Intra	LHX4	Q969G2	SNRNP25	Homo sapiens	Q9BV90	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Pituitary Hormone Deficiency, Combined, 4	Short Stature-Pituitary And Cerebellar Defects-Small Sella Turcica Syndrome CPHD4 Pituitary Hormone Deficiency, Combined, With Or Without Cerebellar Defects Short Stature, Pituitary And Cerebellar Defects, And Small Sella Turcica Pituitary Hormone Deficiency, Combined 4 Pituitary Hormone Deficiency, Combined With Or Without Cerebellar Defects Short Stature, Pituitary And Cerebellar Defects And Small Sella Turcica Pituitary Hormone Deficiency Combined With Or Without Cerebellar Defects Short Stature Pituitary And Cerebellar Defects And Small Sella Turcica Hormone Deficiency, Pituitary, Combined, Type 4
Hypothyroidism Due To Deficient Transcription Factors Involved In Pituitary Development Or Function
Combined Pituitary Hormone Deficiencies, Genetic Forms	Congenital Hypopituitarism Pituitary Hormone Deficiency, Combined 1 Congenital Combined Pituitary Hormone Deficiency Non-Acquired Combined Pituitary Hormone Deficiency Cphd1 Familial Congenital Hypopituitarism Multiple Pituitary Hormone Deficiencies, Genetic Forms Combined Pituitary Hormone Deficiencies, Genetic Form Hormone Deficiency, Pituitary, Combined, Type 1
Pituitary Stalk Interruption Syndrome	Ectopic Neurohypophysis Psis
Hypopituitarism	Pituitary Hypofunction Pituitary Insufficiency Pituitary Hormone Deficiency Subpituitarism Hypophyseal Dystrophy Hypohypophysism Anterior Pituitary Insufficiency Deficient Secretion Of One Or More Pituitary Hormones Hypopituitarism Syndrome Pituitary Deficiency Pituitary Failure Pituitary Insufficiency Nos Anterior Pituitary Hypofunction Deficient Secretion Of All Pituitary Hormones Hypopituitary Dwarfism Hyposomatotropic Dwarfism Hypophyseal Dwarfism Hypopituitary Cachexia Hypophyseal Short Stature Panhypopituitarism Syndrome Pituitary Cachexia Juvenile Hypopituitarism Pituitary Dwarfism Pituitary Gland Hypofunction Primary Hypopituitarism Secondary Hypogonadism Prepubertal Panhypopituitarism Prepubertal Dwarfism Postpartum Panhypopituitary Syndrome Postpartum Hypopituitarism Pituitary Short Stature Pituitary Infantilism Pituitary Hypogonadism Pituitary Hypoadrenocorticism
Pituitary Hormone Deficiency, Combined, 2	Panhypopituitarism Combined Pituitary Hormone Deficiency CPHD2 Ateliotic Dwarfism With Hypogonadism Pituitary Dwarfism Iii Hanhart Dwarfism Simmond'S Disease Simmonds' Disease Cphd Pituitary Hormone Deficiency, Combined Hormone Deficiency, Pituitary, Combined, Type 2 Pituitary Dwarfism Type 3 Sheehan Syndrome
Pituitary Hypoplasia	Hypoplasia Of The Pituitary Gland
Acth Deficiency, Isolated	Adrenocorticotropic Hormone Deficiency IAD Congenital Isolated Acth Deficiency Isolated Acth Deficiency Isolated Adrenocorticotropic Hormone Deficiency Adrenocorticotropic Hormone Deficiency Adrenocorticotropic Hormone [Acth] Deficiency Secondary Adrenocortical Insufficiency
Septooptic Dysplasia	Septo-Optic Dysplasia De Morsier Syndrome Growth Hormone Deficiency With Pituitary Anomalies SOD Pituitary Hormone Deficiency, Combined, 5 Septo-Optic Dysplasia Spectrum Septo-Optic Dysplasia With Growth Hormone Deficiency Pituitary Hormone Deficiency, Combined 5 Hypopituitarism And Septooptic 'Dysplasia' GHDPA CPHD5 Dysplasia, Septo-Optic Kallmann Syndrome
Sheehan Syndrome	Postpartum Hypopituitarism Sheehan'S Syndrome Postpartum Panhypopituitarism Postpartum Panhypopituitary Syndrome Postpartum Pituitary Necrosis Simmond'S Disease
Culler-Jones Syndrome	Postaxial Polydactyly-Anterior Pituitary Anomalies-Facial Dysmorphism Syndrome CJS Pallister-Hall Syndrome 2, Formerly Phs2, Formerly Pallister-Hall Syndrome 2 Phs2
Pituitary Gland Disease	Pituitary Diseases Pituitary Dysfunction Pituitary Disease Pituitary Deficiency Pituitary Disorders
Isolated Growth Hormone Deficiency	Congenital Ighd Congenital Isolated Gh Deficiency Congenital Isolated Growth Hormone Deficiency Non-Acquired Isolated Growth Hormone Deficiency Pituitary Dwarfism Dwarfism, Pituitary Isolated Somatotropin Deficiency Isolated Congenital Growth Hormone Deficiency Familial Isolated Growth Hormone Deficiency Ighd Dwarfism, Growth Hormone Deficiency Growth Hormone Deficiency Dwarfism Isolated Gh Deficiency Isolated Hgh Deficiency Isolated Human Growth Hormone Deficiency Isolated Somatotropin Deficiency Disorder Dwarfism Pituitary
Panhypopituitarism, X-Linked	PHPX X-Linked Panhypopituitarism Pituitary Dwarfism Iv Panhypopituitarism X-Linked Pituitary Dwarfism Iv, Formerly Panhypopituitarism - X-Linked
Hypogonadotropic Hypogonadism	Klinefelter Syndrome Klinefelter'S Syndrome Xxy Syndrome Xxy Trisomy Hypogonadotropism 47, Xxy Congenital Idiopathic Hypogonadotropic Hypogonadism Isolated Congenital Gonadotropin Deficiency 47,Xxy Syndrome 47, Xxy Syndrome Klinefelters Syndrome Hypogonadism Klinefelter Syndrome In Males Klinefelter Syndrome, Unspecified Klinefelter Syndrome Karyotype 47, Xxy
Hypothyroidism	Thyroid Diseases Thyroid Disease Thyroid Deficiency Thyroid Insufficiency Dysfunction Thyroid Thyroid Dysfunction
Otopalatodigital Syndrome, Type I	Otopalatodigital Syndrome Type 1 Taybi Syndrome OPD1 Opd Syndrome 1 Oto-Palato-Digital Syndrome Type 1 Opd I Syndrome Oto-Palato-Digital Syndrome, Type I Otopalatodigital Syndrome Type I Opd Syndrome Cranioorodigital Syndrome Faciopalatoosseous Syndrome Fpo Opd Syndrome, Type 1 Otopalatodigital Syndrome 1
Hypophosphatemic Rickets, X-Linked Recessive	Hypophosphatemic Rickets X-Linked Recessive Hypophosphatemic Rickets XLRHR Hypophosphatemic Rickets Disorders Rickets Hypophosphatemic Rickets, Hypophosphatemic, X-Linked Recessive Familial Hypophosphatemic Rickets
Pallister-Hall Syndrome	PHS Hypothalamic Hamartomas Hypothalamic Hamartoblastoma, Hypopituitarism, Imperforate Anus, And Postaxial Polydactyly Hypothalamic Hamartoblastoma Syndrome Hamartoma Of The Hypothalamus Pallister Hall Syndrome Hall-Pallister Syndrome Hypothalamic Hamartoblastoma Hypopituitarism Imperforate Anus And Postaxial Polydactyly Hamartoma, Hypothalamic
Holoprosencephaly	Holoprosencephaly Sequence Hpe Hpe - [Holoprosencephaly]
Kallmann Syndrome	Hypogonadism With Anosmia Kallman'S Syndrome Anosmic Hypogonadism Anosmic Idiopathic Hypogonadotropic Hypogonadism Hypogonadotropic Hypogonadism And Anosmia Hypogonadotropic Hypogonadism-Anosmia Syndrome Olfacto-Genital Pathological Sequence Familial Hypogonadism With Anosmia Kallman Syndrome Dysplasia Olfactogenitalis Of De Morsier Kallmann'S Syndrome Congenital Hypogonadotropic Hypogonadism With Anosmia
Cryptorchidism, Unilateral Or Bilateral	Cryptorchidism Undescended Testicle Undescended Testis Cryptorchism Undescended Testicles CRYPTO Impaired Testicular Descent Cryptosporidiosis Retained Testis Unilateral Cryptorchidism Unilateral Undescended Testis Nondescent Unilateral Testicle Unilateral Cryptorchism Ectopic Testis, Unilateral Bilateral Cryptorchidism Bilateral Cryptorchism Bilateral Nondescent Testicle Bilateral Undescended Testes Bilateral Ectopic Testes
Congenital Hypothyroidism	Cretinism Neonatal Hypothyroidism Ch Cht Congenital Myxedema Myxedema, Congenital Endemic Cretinism Congenital Iodine-Deficiency Syndrome Fetal Iodine Deficiency Syndrome Congenital Iodine-Deficiency Hypothyroidism Nos
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07634	LHX4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	LHX4	VGNC	VGNC:107893
Rattus norvegicus	LHX4	RGD	RGD:1308044
Canis familiaris	LHX4	VGNC	VGNC:42665
Mus musculus	LHX4	MGD	MGI:101776
Macaca mulatta	LHX4	VGNC	VGNC:106402
Bos taurus	LHX4	VGNC	VGNC:30874
Others	LHX4	NCBI