CORO1B - coronin 1B Gene

Also Known as CORONIN-2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 57175

About CORO1B

Cytogenetic location: 11q13.2 Genomic coordinates (GRCh38): 11:67,435,510-67,443,809 (from NCBI)

This gene has 10 transcripts (splice variants), 200 orthologues and 6 paralogues. Ubiquitous expression in prostate (RPKM 38.7), spleen (RPKM 34.9) and 25 other tissues.

Summary

Members of the coronin family, such as CORO1B, are WD repeat-containing actin-binding proteins that regulate cell motility (Cai et al., 2005 [PubMed 16027158]).[supplied by OMIM, Mar 2008]

CORO1B Products (2)

mRNA	Protein	Name
NM_001018070.3	NP_001018080.1	coronin-1B
NM_020441.3	NP_065174.1	coronin-1B

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables Arp2/3 complex binding	IDA IDA: Inferred from direct assay	16027158	GOA
enables Arp2/3 complex binding	IPI IPI: Inferred from physical interaction	22619279	GOA
enables actin filament binding	IDA IDA: Inferred from direct assay	17456547	GOA
enables actin filament binding	IMP IMP: Inferred from mutant phenotype	22364218	GOA
enables identical protein binding	IDA IDA: Inferred from direct assay	16027158	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16027158	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in actin cytoskeleton organization	IDA IDA: Inferred from direct assay	18775315	GOA
involved in actin filament branching	IDA IDA: Inferred from direct assay	18775315	GOA
involved in actin filament bundle assembly	IDA IDA: Inferred from direct assay	17456547	GOA
involved in cell migration	IDA IDA: Inferred from direct assay	16027158	GOA
involved in cellular response to platelet-derived growth factor stimulus	IMP IMP: Inferred from mutant phenotype	22619279	GOA
involved in endothelial cell chemotaxis	IDA IDA: Inferred from direct assay	23667561	GOA
involved in endothelial cell chemotaxis	IMP IMP: Inferred from mutant phenotype	23667561	GOA
involved in negative regulation of Arp2/3 complex-mediated actin nucleation	IDA IDA: Inferred from direct assay	17350576	GOA
involved in negative regulation of smooth muscle cell chemotaxis	IMP IMP: Inferred from mutant phenotype	22619279	GOA
involved in positive regulation of lamellipodium morphogenesis	IDA IDA: Inferred from direct assay	17350576	GOA
involved in protein localization to cell leading edge	IDA IDA: Inferred from direct assay	17350576	GOA
involved in ruffle organization	IDA IDA: Inferred from direct assay	16027158	GOA
involved in wound healing	IDA IDA: Inferred from direct assay	23667561	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in actin filament	IDA IDA: Inferred from direct assay	18775315	GOA
located in cell leading edge	IDA IDA: Inferred from direct assay	16027158	GOA
located in cell periphery	IDA IDA: Inferred from direct assay	22619279	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	23667561	GOA
located in cytosol	IDA IDA: Inferred from direct assay	22619279	GOA
located in lamellipodium	IDA IDA: Inferred from direct assay	22619279	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	22619279	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	15800061	GOA
located in stress fiber	IDA IDA: Inferred from direct assay	16027158	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CORO1B Protein Structure

DUF1899

WD40

Trimer_CC

0
100
200
300
400
489 a.a.

Protein Preferred Names	Protein Names
coronin-1B	coronin, actin binding protein, 1B

CORO1B Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CORO1B	Q9BR76	SSH1	Homo sapiens	Q8WYL5	Anti Bait CoIP	17350576
Intra	CORO1B	Q9BR76	LHX4	Homo sapiens	Q969G2	Y2H Array	32296183
Intra	CORO1B	Q9BR76	LHX4	Homo sapiens	Q969G2	Y2H Prey Pooling	32296183
Intra	CORO1B	Q9BR76	CORO1C	Homo sapiens	Q9ULV4	Anti Tag CoIP	35271311
Intra	CORO1B	Q9BR76	CORO1C	Homo sapiens	Q9ULV4	Anti Bait CoIP	26655834
Intra	CORO1B	Q9BR76	ARPC2	Homo sapiens	O15144	Anti Bait CoIP	17350576
Intra	CORO1B	Q9BR76	TERF1	Homo sapiens	P54274	Pull Down	21044950
Intra	CORO1B	Q9BR76	TERF1	Homo sapiens	P54274	BiFC	21044950

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Coronin-1a Deficiency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03049	CORO1B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CORO1B	MGD	MGI:1345963
Macaca mulatta	CORO1B	VGNC	VGNC:71320
Rattus norvegicus	CORO1B	RGD	RGD:2382
Bos taurus	CORO1B	VGNC	VGNC:27621
Felis catus	CORO1B	VGNC	VGNC:61102