2. Gene
  3. CORO1C - coronin 1C Gene

CORO1C - coronin 1C Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as HCRNN4

Gene ID: 23603 | Gene type: protein coding

About CORO1C

Cytogenetic location: 12q24.11 Genomic coordinates (GRCh38): 12:108,645,109-108,731,518 (from NCBI)

This gene has 19 transcripts (splice variants), 289 orthologues and 6 paralogues. Ubiquitous expression in endometrium (RPKM 30.8), lung (RPKM 27.0) and 24 other tissues.

Summary

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 Amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, Apoptosis, and gene regulation. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]

CORO1C Products(3)

mRNA Protein Name
NM_001105237.2 NP_001098707.1 coronin-1C isoform a
NM_001276471.2 NP_001263400.1 coronin-1C isoform b
NM_014325.4 NP_055140.1 coronin-1C isoform b

CORO1C Protein Structure

DUF1899

DUF1899: Domain of unknown function (DUF1899) (3 - 67)

WD40

WD40: WD domain, G-beta repeat (75 - 108)

WD40

WD40: WD domain, G-beta repeat (121 - 159)

WD40

WD40: WD domain, G-beta repeat (173 - 202)

Trimer_CC

Trimer_CC: Trimerisation motif (256 - 390)

  • 0
  • 100
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  • 400
  • 474 a.a.
Protein Preferred Names Protein Names

coronin-1C

coronin, actin binding protein, 1C

Related Diseases

Diseases Alias
Colorectal Cancer, Hereditary Nonpolyposis, Type 2

HNPCC2

Fcc2

Coca2

Hereditary Nonpolyposis Colorectal Cancer Type 2

Colon Cancer, Familial Nonpolyposis, Type 2

Familial Nonpolyposis Colon Cancer Type 2

Hereditary Non-Polyposis Colorectal Cancer 2

Cancer, Colorectal, Nonpolyposis, Hereditary, Type 2
Coronin-1a Deficiency
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03050 CORO1C Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus CORO1C MGD MGI:1345964
Macaca mulatta CORO1C VGNC VGNC:71321
Rattus norvegicus CORO1C RGD RGD:1564490
Bos taurus CORO1C VGNC VGNC:27622
Felis catus CORO1C VGNC VGNC:61103
Canis familiaris CORO1C VGNC VGNC:39528