CORO1C - coronin 1C Gene

Also Known as HCRNN4

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23603

About CORO1C

Cytogenetic location: 12q24.11 Genomic coordinates (GRCh38): 12:108,645,109-108,731,518 (from NCBI)

This gene has 19 transcripts (splice variants), 289 orthologues and 6 paralogues. Ubiquitous expression in endometrium (RPKM 30.8), lung (RPKM 27.0) and 24 other tissues.

Summary

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 Amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, Apoptosis, and gene regulation. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]

CORO1C Products (3)

mRNA	Protein	Name
NM_001105237.2	NP_001098707.1	coronin-1C isoform a
NM_001276471.2	NP_001263400.1	coronin-1C isoform b
NM_014325.4	NP_055140.1	coronin-1C isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables actin filament binding	IMP IMP: Inferred from mutant phenotype	22364218	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25074804	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in endosomal transport	IDA IDA: Inferred from direct assay	30220460	GOA
involved in endosome fission	IDA IDA: Inferred from direct assay	30220460	GOA
involved in endosome membrane tubulation	IDA IDA: Inferred from direct assay	30220460	GOA
involved in membrane fission	IDA IDA: Inferred from direct assay	30220460	GOA
involved in negative regulation of epithelial cell migration	IMP IMP: Inferred from mutant phenotype	19913511	GOA
involved in negative regulation of focal adhesion assembly	IMP IMP: Inferred from mutant phenotype	19913511	GOA
involved in negative regulation of protein kinase activity by regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	19913511	GOA
involved in negative regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	19913511	GOA
involved in negative regulation of substrate adhesion-dependent cell spreading	IMP IMP: Inferred from mutant phenotype	19913511	GOA
involved in neural crest cell migration	IMP IMP: Inferred from mutant phenotype	25074804	GOA
involved in positive regulation of lamellipodium morphogenesis	IMP IMP: Inferred from mutant phenotype	19913511	GOA
involved in regulation of epithelial cell migration	IGI IGI: Inferred from genetic interaction	19913511	GOA
involved in regulation of focal adhesion assembly	IGI IGI: Inferred from genetic interaction	19913511	GOA
involved in regulation of protein phosphorylation	IGI IGI: Inferred from genetic interaction	19913511	GOA
involved in regulation of substrate adhesion-dependent cell spreading	IGI IGI: Inferred from genetic interaction	19913511	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in actin cytoskeleton	IDA IDA: Inferred from direct assay	22364218	GOA
located in endosome membrane	IDA IDA: Inferred from direct assay	30220460	GOA
NOT colocalizes with focal adhesion	IDA IDA: Inferred from direct assay	19913511	GOA
located in lamellipodium	IDA IDA: Inferred from direct assay	22364218	GOA
located in lateral plasma membrane	IDA IDA: Inferred from direct assay	25074804	GOA
colocalizes with vesicle	IDA IDA: Inferred from direct assay	25074804	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CORO1C Protein Structure

DUF1899

WD40

Trimer_CC

0
100
200
300
400
474 a.a.

Protein Preferred Names	Protein Names
coronin-1C	coronin, actin binding protein, 1C

CORO1C Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CORO1C	Q9ULV4	CORO1B	Homo sapiens	Q9BR76	Anti Tag CoIP	28514442
Intra	CORO1C	Q9ULV4	CORO1B	Homo sapiens	Q9BR76	Anti Tag CoIP	33961781
Intra	CORO1C	Q9ULV4	CORO1B	Homo sapiens	Q9BR76	Anti Tag CoIP	35271311

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Colorectal Cancer, Hereditary Nonpolyposis, Type 2	HNPCC2 Fcc2 Coca2 Hereditary Nonpolyposis Colorectal Cancer Type 2 Colon Cancer, Familial Nonpolyposis, Type 2 Familial Nonpolyposis Colon Cancer Type 2 Hereditary Non-Polyposis Colorectal Cancer 2 Cancer, Colorectal, Nonpolyposis, Hereditary, Type 2
Coronin-1a Deficiency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03050	CORO1C Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CORO1C	MGD	MGI:1345964
Macaca mulatta	CORO1C	VGNC	VGNC:71321
Rattus norvegicus	CORO1C	RGD	RGD:1564490
Bos taurus	CORO1C	VGNC	VGNC:27622
Felis catus	CORO1C	VGNC	VGNC:61103
Canis familiaris	CORO1C	VGNC	VGNC:39528
Others	CORO1C	NCBI