country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

DHRS1 - dehydrogenase/reductase 1 Gene

Also Known as SDR19C1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 115817

About DHRS1

Cytogenetic location: 14q12 Genomic coordinates (GRCh38): 14:24,290,598-24,299,780 (from NCBI)

This gene has 11 transcripts (splice variants), 1 gene allele, 197 orthologues and 13 paralogues. Ubiquitous expression in liver (RPKM 39.6), esophagus (RPKM 38.5) and 24 other tissues.

Summary

This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family. The encoded enzyme contains a conserved catalytic domain and likely functions as an oxidoreductase. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2008]

DHRS1 Products (2)

mRNA	Protein	Name
NM_001136050.3	NP_001129522.1	dehydrogenase/reductase SDR family member 1
NM_138452.3	NP_612461.1	dehydrogenase/reductase SDR family member 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables carbonyl reductase (NADPH) activity	IDA IDA: Inferred from direct assay	30031147	GOA
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IDA IDA: Inferred from direct assay	30031147	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DHRS1 Protein Structure

adh_short

0
100
200
313 a.a.

Protein Preferred Names	Protein Names
dehydrogenase/reductase SDR family member 1	dehydrogenase/reductase (SDR family) member 1

DHRS1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	DHRS1	Q96LJ7	KRTAP10-8	Homo sapiens	P60410	Y2H Array	32296183
Intra	DHRS1	Q96LJ7	KRTAP10-8	Homo sapiens	P60410	Validated Y2H	25416956
Intra	DHRS1	Q96LJ7	KRTAP10-8	Homo sapiens	P60410	Y2H Prey Pooling	32296183
Intra	DHRS1	Q96LJ7	KRTAP10-9	Homo sapiens	P60411	Y2H Prey Pooling	32296183
Intra	DHRS1	Q96LJ7	KRTAP10-9	Homo sapiens	P60411	Y2H Array	32296183
Intra	DHRS1	Q96LJ7	KRTAP12-2	Homo sapiens	P59991	Y2H Array	32296183
Intra	DHRS1	Q96LJ7	KRTAP12-2	Homo sapiens	P59991	Y2H Prey Pooling	32296183
Intra	DHRS1	Q96LJ7	KRTAP12-1	Homo sapiens	P59990	Y2H Prey Pooling	32296183
Intra	DHRS1	Q96LJ7	KRTAP12-1	Homo sapiens	P59990	Y2H Array	32296183
Intra	DHRS1	Q96LJ7	KRTAP4-11	Homo sapiens	Q9BYQ6	Y2H Prey Pooling	32296183
Intra	DHRS1	Q96LJ7	KRTAP4-11	Homo sapiens	Q9BYQ6	Validated Y2H	32296183
Intra	DHRS1	Q96LJ7	KRTAP4-11	Homo sapiens	Q9BYQ6	Y2H Array	32296183
Intra	DHRS1	Q96LJ7	KRT34	Homo sapiens	O76011	Y2H Prey Pooling	32296183
Intra	DHRS1	Q96LJ7	KRT34	Homo sapiens	O76011	Y2H Array	32296183
Intra	DHRS1	Q96LJ7	KRTAP11-1	Homo sapiens	Q8IUC1	Y2H Array	32296183
Intra	DHRS1	Q96LJ7	KRTAP11-1	Homo sapiens	Q8IUC1	Y2H Prey Pooling	32296183
Intra	DHRS1	Q96LJ7	LCE2B	Homo sapiens	O14633	Y2H Array	32296183
Intra	DHRS1	Q96LJ7	LCE2B	Homo sapiens	O14633	Y2H Prey Pooling	32296183
Intra	DHRS1	Q96LJ7	MTUS2	Homo sapiens	Q5JR59-3	Y2H Array	32296183
Intra	DHRS1	Q96LJ7	MTUS2	Homo sapiens	Q5JR59-3	Y2H Prey Pooling	32296183
Intra	DHRS1	Q96LJ7	KRTAP1-3	Homo sapiens	Q8IUG1	Y2H Prey Pooling	32296183
Intra	DHRS1	Q96LJ7	KRTAP1-3	Homo sapiens	Q8IUG1	Y2H Array	32296183
Intra	DHRS1	Q96LJ7	KRTAP12-3	Homo sapiens	P60328	Y2H Prey Pooling	32296183
Intra	DHRS1	Q96LJ7	KRTAP12-3	Homo sapiens	P60328	Y2H Array	32296183
Intra	DHRS1	Q96LJ7	KRTAP5-2	Homo sapiens	Q701N4	Y2H Array	32296183
Intra	DHRS1	Q96LJ7	KRTAP5-2	Homo sapiens	Q701N4	Y2H Prey Pooling	32296183
Intra	DHRS1	Q96LJ7	KRTAP9-8	Homo sapiens	Q9BYQ0	Validated Y2H	32296183
Intra	DHRS1	Q96LJ7	KRTAP9-8	Homo sapiens	Q9BYQ0	Y2H Prey Pooling	32296183
Intra	DHRS1	Q96LJ7	KRTAP9-8	Homo sapiens	Q9BYQ0	Y2H Array	32296183
Intra	DHRS1	Q96LJ7	KRTAP1-1	Homo sapiens	Q07627	Y2H Array	32296183
Intra	DHRS1	Q96LJ7	KRTAP1-1	Homo sapiens	Q07627	Y2H Prey Pooling	32296183
Intra	DHRS1	Q96LJ7	KRTAP6-2	Homo sapiens	Q3LI66	Y2H Array	32296183
Intra	DHRS1	Q96LJ7	KRTAP6-2	Homo sapiens	Q3LI66	Y2H Prey Pooling	32296183
Intra	DHRS1	Q96LJ7	KRTAP5-1	Homo sapiens	Q6L8H4	Y2H Prey Pooling	32296183
Intra	DHRS1	Q96LJ7	KRTAP5-1	Homo sapiens	Q6L8H4	Y2H Array	32296183
Intra	DHRS1	Q96LJ7	LAMP2	Homo sapiens	P13473-2	Y2H Pooling	32814053
Intra	DHRS1	Q96LJ7	LAMP2	Homo sapiens	P13473-2	Validated Y2H	32814053
Intra	DHRS1	Q96LJ7	LAMP2	Homo sapiens	P13473-2	Y2H Array	32814053
Intra	DHRS1	Q96LJ7	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Array	32296183
Intra	DHRS1	Q96LJ7	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Prey Pooling	32296183
Intra	DHRS1	Q96LJ7	KRTAP6-3	Homo sapiens	Q3LI67	Y2H Prey Pooling	32296183
Intra	DHRS1	Q96LJ7	KRTAP6-3	Homo sapiens	Q3LI67	Y2H Array	32296183
Intra	DHRS1	Q96LJ7	SH3GLB1	Homo sapiens	Q9Y371	Validated Y2H	32814053
Intra	DHRS1	Q96LJ7	SH3GLB1	Homo sapiens	Q9Y371	Y2H Pooling	32814053
Intra	DHRS1	Q96LJ7	SH3GLB1	Homo sapiens	Q9Y371	Y2H Array	32814053
Intra	DHRS1	Q96LJ7	LHX4	Homo sapiens	Q969G2	Y2H Prey Pooling	32296183
Intra	DHRS1	Q96LJ7	LHX4	Homo sapiens	Q969G2	Y2H Array	32296183
Intra	DHRS1	Q96LJ7	KRTAP4-1	Homo sapiens	Q9BYQ7	Y2H Array	32296183
Intra	DHRS1	Q96LJ7	KRTAP4-1	Homo sapiens	Q9BYQ7	Y2H Prey Pooling	32296183
Intra	DHRS1	Q96LJ7	KRTAP5-9	Homo sapiens	P26371	Y2H Prey Pooling	25416956
Intra	DHRS1	Q96LJ7	DIABLO	Homo sapiens	Q9NR28	Validated Y2H	32296183
Intra	DHRS1	Q96LJ7	MDFI	Homo sapiens	Q99750	Y2H Prey Pooling	32296183
Intra	DHRS1	Q96LJ7	MDFI	Homo sapiens	Q99750	Validated Y2H	32296183
Intra	DHRS1	Q96LJ7	MDFI	Homo sapiens	Q99750	Y2H Array	32296183
Intra	DHRS1	Q96LJ7	KRTAP3-2	Homo sapiens	Q9BYR7	Y2H Prey Pooling	25416956
Intra	DHRS1	Q96LJ7	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Array	25416956
Intra	DHRS1	Q96LJ7	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

DHRS1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P86266	DHRS1 Antibody (YA5958)	WB	Human

Related Diseases

Diseases	Alias
Nevus, Epidermal	Epidermal Nevus Woolly Hair Nevus Epidermal Naevus Epidermal Nevus Syndrome Nevus, Keratinocytic, Nonepidermolytic Epidermal Nevus, Somatic Nevus, Epidermal, Somatic Nevus Sebaceous Or Woolly Hair Nevus, Somatic Nonepidermolytic Keratinocytic Nevus Epidermal Hamartoma Syndrome Wooly Hair Nevus Keratinocytic Non-Epidermolytic Nevus KNEN Pigmented Moles Organoid Nevus Phakomatosis Nevus Sebaceous Melanocytic Nevus Melanocytic Nevus Of Skin

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03738	DHRS1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20391	Dhrs1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26900	Dhrs1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	DHRS1	RGD	RGD:1359172
Mus musculus	DHRS1	MGD	MGI:1196314
Canis familiaris	DHRS1	VGNC	VGNC:56058
Bos taurus	DHRS1	VGNC	VGNC:28039
Macaca mulatta	DHRS1	VGNC	VGNC:71629
Felis catus	DHRS1	VGNC	VGNC:61468
Others	DHRS1	NCBI