MYOZ1 - myozenin 1 Gene

Also Known as CS-2; FATZ; MYOZ

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 58529

About MYOZ1

Cytogenetic location: 10q22.2 Genomic coordinates (GRCh38): 10:73,631,612-73,641,474 (from NCBI)

This gene has 1 transcript (splice variant), 275 orthologues and 2 paralogues. Biased expression in esophagus (RPKM 24.9), prostate (RPKM 22.9) and 4 other tissues.

Summary

The protein encoded by this gene is primarily expressed in the skeletal muscle, and belongs to the myozenin family. Members of this family function as calcineurin-interacting proteins that help tether Calcineurin to the sarcomere of cardiac and skeletal muscle. They play an important role in modulation of Calcineurin signaling. [provided by RefSeq, Apr 2012]

MYOZ1 Products (1)

mRNA	Protein	Name
NM_021245.4	NP_067068.1	myozenin-1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables FATZ binding	IDA IDA: Inferred from direct assay	10984498	GOA
enables actinin binding	EXP EXP: Inferred from Experiment	34049882	GOA
enables actinin binding	IMP IMP: Inferred from mutant phenotype	34049882	GOA
enables actinin binding	IPI IPI: Inferred from physical interaction	34049882	GOA
enables molecular condensate scaffold activity	IDA IDA: Inferred from direct assay	34049882	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10427098	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MYOZ1 Protein Structure

Calsarcin

0
100
200
299 a.a.

Protein Preferred Names	Protein Names
myozenin-1	calsarcin-2

MYOZ1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MYOZ1	Q9NP98	KRTAP12-2	Homo sapiens	P59991	Y2H Array	32296183
Intra	MYOZ1	Q9NP98	KRTAP12-2	Homo sapiens	P59991	Y2H Prey Pooling	32296183
Intra	MYOZ1	Q9NP98	KRT34	Homo sapiens	O76011	Y2H Prey Pooling	32296183
Intra	MYOZ1	Q9NP98	KRT34	Homo sapiens	O76011	Y2H Array	32296183
Intra	MYOZ1	Q9NP98	GOLGA6A	Homo sapiens	Q9NYA3	Y2H Array	32296183
Intra	MYOZ1	Q9NP98	GOLGA6A	Homo sapiens	Q9NYA3	Validated Y2H	32296183
Intra	MYOZ1	Q9NP98	GOLGA6A	Homo sapiens	Q9NYA3	Y2H Prey Pooling	32296183
Intra	MYOZ1	Q9NP98	KRT36	Homo sapiens	O76013-2	Y2H Prey Pooling	32296183
Intra	MYOZ1	Q9NP98	KRT36	Homo sapiens	O76013-2	Y2H Array	32296183
Intra	MYOZ1	Q9NP98	WWOX	Homo sapiens	Q9NZC7-5	Validated Y2H	32296183
Intra	MYOZ1	Q9NP98	WWOX	Homo sapiens	Q9NZC7-5	Y2H Array	32296183
Intra	MYOZ1	Q9NP98	WWOX	Homo sapiens	Q9NZC7-5	Y2H Prey Pooling	32296183
Intra	MYOZ1	Q9NP98	VAC14	Homo sapiens	Q08AM6	Y2H Array	32296183
Intra	MYOZ1	Q9NP98	VAC14	Homo sapiens	Q08AM6	Y2H Prey Pooling	32296183
Intra	MYOZ1	Q9NP98	LHX4	Homo sapiens	Q969G2	Y2H Prey Pooling	32296183
Intra	MYOZ1	Q9NP98	LHX4	Homo sapiens	Q969G2	Y2H Array	32296183
Intra	MYOZ1	Q9NP98	ACTN3	Homo sapiens	Q08043	Y2H Prey Pooling	32296183
Intra	MYOZ1	Q9NP98	ACTN3	Homo sapiens	Q08043	Y2H Array	32296183
Intra	MYOZ1	Q9NP98	BAG4	Homo sapiens	O95429	Y2H Array	32296183
Intra	MYOZ1	Q9NP98	BAG4	Homo sapiens	O95429	Y2H Prey Pooling	32296183
Intra	MYOZ1	Q9NP98	PNMA1	Homo sapiens	Q8ND90	Y2H Array	32296183
Intra	MYOZ1	Q9NP98	PNMA1	Homo sapiens	Q8ND90	Y2H Prey Pooling	32296183
Intra	MYOZ1	Q9NP98	ACTN1	Homo sapiens	P12814	Y2H Array	32296183
Intra	MYOZ1	Q9NP98	ACTN1	Homo sapiens	P12814	Y2H Prey Pooling	32296183
Intra	MYOZ1	Q9NP98	PFDN5	Homo sapiens	Q99471	Y2H Array	32296183
Intra	MYOZ1	Q9NP98	PFDN5	Homo sapiens	Q99471	Y2H Prey Pooling	32296183
Intra	MYOZ1	Q9NP98	VBP1	Homo sapiens	P61758	Y2H Prey Pooling	32296183
Intra	MYOZ1	Q9NP98	VBP1	Homo sapiens	P61758	Y2H Array	32296183
Intra	MYOZ1	Q9NP98	AKAP8L	Homo sapiens	Q9ULX6	Y2H Prey Pooling	32296183
Intra	MYOZ1	Q9NP98	AKAP8L	Homo sapiens	Q9ULX6	Validated Y2H	32296183
Intra	MYOZ1	Q9NP98	AKAP8L	Homo sapiens	Q9ULX6	Y2H Array	32296183
Intra	MYOZ1	Q9NP98	TRAF1	Homo sapiens	Q13077	Y2H Prey Pooling	32296183
Intra	MYOZ1	Q9NP98	TRAF1	Homo sapiens	Q13077	Y2H Array	32296183
Intra	MYOZ1	Q9NP98	EXOSC8	Homo sapiens	Q96B26	Y2H Prey Pooling	32296183
Intra	MYOZ1	Q9NP98	EXOSC8	Homo sapiens	Q96B26	Y2H Array	32296183
Intra	MYOZ1	Q9NP98	CEACAM6	Homo sapiens	P40199	Y2H Prey Pooling	32296183
Intra	MYOZ1	Q9NP98	CEACAM6	Homo sapiens	P40199	Y2H Array	32296183
Intra	MYOZ1	Q9NP98	TRIM63	Homo sapiens	Q969Q1	Pull Down	18157088
Intra	MYOZ1	Q9NP98	EIF3F	Homo sapiens	O00303	Y2H Array	32296183
Intra	MYOZ1	Q9NP98	EIF3F	Homo sapiens	O00303	Y2H Prey Pooling	32296183
Intra	MYOZ1	Q9NP98	WASHC3	Homo sapiens	Q9Y3C0	Y2H Array	32296183
Intra	MYOZ1	Q9NP98	WASHC3	Homo sapiens	Q9Y3C0	Y2H Prey Pooling	32296183
Intra	MYOZ1	Q9NP98	WASHC3	Homo sapiens	Q9Y3C0	Validated Y2H	32296183
Intra	MYOZ1	Q9NP98	USHBP1	Homo sapiens	Q8N6Y0	Y2H Prey Pooling	32296183
Intra	MYOZ1	Q9NP98	USHBP1	Homo sapiens	Q8N6Y0	Y2H Array	32296183
Intra	MYOZ1	Q9NP98	TRIM23	Homo sapiens	P36406	Y2H Prey Pooling	32296183
Intra	MYOZ1	Q9NP98	TRIM23	Homo sapiens	P36406	Y2H Array	32296183
Intra	MYOZ1	Q9NP98	LZTS2	Homo sapiens	Q9BRK4	Y2H Array	32296183
Intra	MYOZ1	Q9NP98	LZTS2	Homo sapiens	Q9BRK4	Y2H Prey Pooling	32296183
Intra	MYOZ1	Q9NP98	CEP76	Homo sapiens	Q8TAP6	Y2H Array	32296183
Intra	MYOZ1	Q9NP98	CEP76	Homo sapiens	Q8TAP6	Y2H Prey Pooling	32296183
Intra	MYOZ1	Q9NP98	CRX	Homo sapiens	O43186	Y2H Array	32296183
Intra	MYOZ1	Q9NP98	CRX	Homo sapiens	O43186	Y2H Prey Pooling	32296183
Intra	MYOZ1	Q9NP98	PLEKHG4	Homo sapiens	Q58EX7	Y2H Prey Pooling	32296183
Intra	MYOZ1	Q9NP98	PLEKHG4	Homo sapiens	Q58EX7	Y2H Array	32296183
Intra	MYOZ1	Q9NP98	FLNA	Homo sapiens	P21333-2	Validated Y2H	32814053
Intra	MYOZ1	Q9NP98	FLNA	Homo sapiens	P21333-2	Y2H Prey Pooling	32296183
Intra	MYOZ1	Q9NP98	FLNA	Homo sapiens	P21333-2	Y2H Array	32814053
Intra	MYOZ1	Q9NP98	FLNA	Homo sapiens	P21333-2	Y2H Pooling	32814053
Intra	MYOZ1	Q9NP98	FLNA	Homo sapiens	P21333-2	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Myopathy, Myofibrillar, 4	Myofibrillar Myopathy 4 MFM4 Zaspopathy Myopathy, Myofibrillar, Zasp-Related
Myopathy, Spheroid Body	Spheroid Body Myopathy Autosomal Dominant Spheroid Body Myopathy SBM
Myopathy, Myofibrillar, 3	Myotilinopathy Myofibrillar Myopathy 3 MFM3 Autosomal Dominant Limb-Girdle Muscular Dystrophy Type 1a Lgmd1a Muscular Dystrophy, Limb-Girdle, Type 1a Myopathy, Myofibrillar, Myotilin-Related Muscular Dystrophy, Limb-Girdle, Type 1, Formerly Lgmd1, Formerly Muscular Dystrophy, Limb-Girdle, Type 1a, Formerly Lgmd1a, Formerly Qualitative Or Quantitative Defects Of Myotilin Limb-Girdle Muscular Dystrophy Due To Myotilin Deficiency Distal Myotilinopathy Lgmd1 Limb-Girdle Muscular Dystrophy 1a Mfm Myotilin-Related Muscular Dystrophy, Limb-Girdle, Type 1 Myopathy Myofibrillar Myotylin-Related Myopathy, Myofibrillar, Type 3
Myopathy, Myofibrillar, 5	Myofibrillar Myopathy 5 MFM5 Myopathy, Myofibrillar, Filamin C-Related Filaminopathy, Autosomal Dominant Filaminopathy Muscle Filaminopathy Autosomal Dominant Filaminopathy Mfm Filamin C-Related Myopathy Myofibrillar Filamin C-Related Myopathy, Myofibrillar, Type 5
Myofibrillar Myopathy	Desmin Related Myopathy Myotilinopathy Myopathy, Myofibrillar Alpha Beta Crystallinopathy Desmin Storage Myopathy Desminopathy Filaminopathy Protein Surplus Myopathy Zaspopathy Myofibrillar Myopathies Myopathy, Myofibrillar, Desmin-Related Myopathy, Desmin Storage Mfm - [Myofibrillar Myopathy]
Cardiomyopathy, Dilated, 3b	Dilated Cardiomyopathy 3b CMD3B X-Linked Dilated Cardiomyopathy Xlcm Dmd-Associated Dilated Cardiomyopathy Cardiomyopathy, Dilated, X-Linked Dmd-Related Dilated Cardiomyopathy Xldc Cardiomyopathy, Dilated, X-Linked 3b Cardiomyopathy, Dilated, Type 3b
Postural Orthostatic Tachycardia Syndrome	Irritable Heart Mitral Valve Prolapse Syndrome Neurocirculatory Asthenia Orthostatic Intolerance Due To Net Deficiency Familial Orthostatic Tachycardia Due To Norepinephrine Transporter Deficiency Orhtostatic Intolerance Postural Tachycardia Syndrome Due To Net Deficiency Soldiers Heart
Myopathy	Muscular Diseases Myopathies
Left Ventricular Noncompaction	Noncompaction Cardiomyopathy Left Ventricular Hypertrabeculation Lvnc Spongy Myocardium Isolated Noncompaction Of The Ventricular Myocardium Left Ventricular Myocardial Noncompaction Cardiomyopathy Fetal Myocardium Honeycomb Myocardium Hypertrabeculation Syndrome Left Ventricular Non-Compaction Lvht Non-Compaction Of The Left Ventricular Myocardium Ventricular Noncompaction, Left Non-Compaction Cardiomyopathy
Cardiomyopathy, Familial Hypertrophic, 1	Asymmetric Septal Hypertrophy Familial Hypertrophic Cardiomyopathy Hypertrophic Cardiomyopathy 1 CMH1 Hypertrophic Cardiomyopathy 19 CMH Ventricular Hypertrophy, Hereditary Ash Hypertrophic Subaortic Stenosis, Idiopathic Cardiomyopathy, Familial Hypertrophic Cardiomyopathy, Hypertrophic, 1, Digenic Cardiomyopathy, Familial Hypertrophic 1 Hcm Hereditary Ventricular Hypertrophy Idiopathic Hypertrophic Subaortic Stenosis Hypertrophic Cardiomyopathy Cardiomyopathy, Hypertrophic, Familial Cardiomyopathy, Hypertrophic, 1 Familial Asymmetric Septal Hypertrophy Heritable Hypertrophic Cardiomyopathy Fhc Cardiomyopathy, Hypertrophic, Familial, Type 1
Hypertrophic Cardiomyopathy	Hypertrophic Obstructive Cardiomyopathy Cardiomyopathy, Hypertrophic Cardiomyopathy Hypertrophic Obstructive Cardiomyopathy, Hypertrophic, Familial Idiopathic Myocardial Hypertrophy Idiopathic Hypertrophic Cardiomyopathy Obstructive Idiopathic Hypertrophic Cardiomyopathy Obstructive Cardiomyopathy Idiopathic Hypertrophic Subaortic Stenosis Muscular Subaortic Stenosis Hypertrophic Obstructive Subaortic Stenosis
Dilated Cardiomyopathy	Familial Dilated Cardiomyopathy Primary Dilated Cardiomyopathy Idiopathic Dilated Cardiomyopathy Congestive Cardiomyopathy Idiopathic Dilation Cardiomyopathy Primary Familial Dilated Cardiomyopathy Cardiomyopathy, Dilated DCM Cardiomyopathy, Familial Dilated Dilated Cardiomyopathy, Familial Hypokinetic Dilated Cardiomyopathy, Familial Familial Idiopathic Cardiomyopathy Fdc Cardiomyopathy, Familial Idiopathic Idiopathic Cardiomegaly Dilated Congestive Cardiomyopathy Chronic Dilated Cardiomyopathy Ccm - [Congestive Cardiomyopathy] Cocm - [Congestive Cardiomyopathy] Dcm - [Dilated Cardiomyopathy] Dilated-Hypokinetic Cardiomyopathy Congestive Idiopathic Cardiomyopathy Primary Idiopathic Dilated Cardiomyopathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08965	MYOZ1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	MYOZ1	VGNC	VGNC:63693
Rattus norvegicus	MYOZ1	RGD	RGD:1561064
Bos taurus	MYOZ1	VGNC	VGNC:31840
Macaca mulatta	MYOZ1	VGNC	VGNC:74951
Mus musculus	MYOZ1	MGD	MGI:1929471
Canis familiaris	MYOZ1	VGNC	VGNC:43583
Others	MYOZ1	NCBI