TRIM63 - tripartite motif containing 63 Gene

Also Known as IRF; SMRZ; MURF1; MURF2; RNF28

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 84676

About TRIM63

Cytogenetic location: 1p36.11 Genomic coordinates (GRCh38): 1:26,051,301-26,067,630 (from NCBI)

This gene has 2 transcripts (splice variants), 139 orthologues and 80 paralogues. Biased expression in heart (RPKM 44.7) and esophagus (RPKM 2.8).

Summary

This gene encodes a member of the RING Zinc Finger Protein family found in striated muscle and iris. The product of this gene is an E3 ubiquitin Ligase that localizes to the Z-line and M-line lattices of myofibrils. This protein plays an important role in the atrophy of skeletal and cardiac muscle and is required for the degradation of Myosin heavy chain proteins, Myosin light chain, Myosin binding protein, and for muscle-type Creatine Kinase. [provided by RefSeq, Feb 2012]

TRIM63 Products (1)

mRNA	Protein	Name
NM_032588.4	NP_115977.2	E3 ubiquitin-protein ligase TRIM63

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18157088	GOA
enables titin binding	IDA IDA: Inferred from direct assay	11927605	GOA
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	34244144	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of glycolytic process	IMP IMP: Inferred from mutant phenotype	34244144	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	11927605	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRIM63 Protein Structure

zf-C3HC4_2

zf-B_box

0
100
200
300
353 a.a.

Protein Preferred Names	Protein Names
E3 ubiquitin-protein ligase TRIM63	RING-type E3 ubiquitin transferase TRIM63

TRIM63 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TRIM63	Q969Q1	TTN	Homo sapiens	Q8WZ42	Y2H	18157088
Intra	TRIM63	Q969Q1	TTN	Homo sapiens	Q8WZ42	Y2H Fragment Pooling	23414517
Intra	TRIM63	Q969Q1	USP13	Homo sapiens	Q92995	Y2H Prey Pooling	31391242
Intra	TRIM63	Q969Q1	USP13	Homo sapiens	Q92995	Anti Tag CoIP	31391242
Intra	TRIM63	Q969Q1	DCAF8	Homo sapiens	Q5TAQ9	IF	31391242
Intra	TRIM63	Q969Q1	DCAF8	Homo sapiens	Q5TAQ9	Anti Tag CoIP	31391242
Intra	TRIM63	Q969Q1	MYOZ1	Homo sapiens	Q9NP98	Y2H	18157088
Intra	TRIM63	Q969Q1	MRPL41	Homo sapiens	Q8IXM3	Y2H	18157088

Cross: Cross-species interaction Intra: Intraspecies interaction

TRIM63 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P810136	MuRF1 Antibody (YA9480)	WB, IP, ELISA	human
HY-P84719	MuRF1 Antibody (YA4416)	IHC-P, ICC/IF, FC, ELISA	Human
HY-P84719A	MuRF1 Antibody (YA4416)(PBS only)	IHC-P, ICC/IF, FC, ELISA	Human

Related Diseases

Diseases	Alias
Hypertrophic Cardiomyopathy	Hypertrophic Obstructive Cardiomyopathy Cardiomyopathy, Hypertrophic Cardiomyopathy Hypertrophic Obstructive Cardiomyopathy, Hypertrophic, Familial Idiopathic Myocardial Hypertrophy Idiopathic Hypertrophic Cardiomyopathy Obstructive Idiopathic Hypertrophic Cardiomyopathy Obstructive Cardiomyopathy Idiopathic Hypertrophic Subaortic Stenosis Muscular Subaortic Stenosis Hypertrophic Obstructive Subaortic Stenosis
Muscular Atrophy	Muscle Wasting Amyotrophia Wasting - Muscle Skeletal Muscle Atrophy
Myopathy, Myofibrillar, 9, With Early Respiratory Failure	Hereditary Myopathy With Early Respiratory Failure Hmerf Myopathy, Proximal, With Early Respiratory Muscle Involvement Edstrom Myopathy Mfm-Titinopathy MFM9 Mprm Hereditary Inclusion Body Myopathy With Early Respiratory Failure Hibm-Erf Myofibrillar Myopathy-Titinopathy Myofibrillar Myopathy With Early Respiratory Failure Myopathy, Distal, With Early Respiratory Failure, Autosomal Dominant Myofibrillar Myopathy 9 Myofibrillar Myopathy 9 With Early Respiratory Failure Autosomal Dominant Distal Myopathy With Early Respiratory Failure Proximal Myopathy With Early Respiratory Muscle Involvement Hereditary Proximal Myopathy With Early Respiratory Failure Admerf Edström Myopathy Hmerf-Erf
Hyaline Body Myopathy	Myosin Storage Myopathy Autosomal Dominant Hyaline Body Myopathy Myopathy, Myosin Storage
Muscle Tissue Disease
Critical Illness Polyneuropathy	Polyneuropathy, Critical Illness
Muscular Disease
Viral Infectious Disease	Viral Disease Arbovirus Infections Virus Infection Virus Diseases Viral Infection Viral Infections Virus Infections
Ullrich Congenital Muscular Dystrophy 1	Ullrich Congenital Muscular Dystrophy Ullrich Disease Ucmd Ullrich Scleroatonic Muscular Dystrophy Scleroatonic Muscular Dystrophy UCMD1 Muscular Dystrophy, Limb-Girdle, Autosomal Recessive 22 Lgmdr22 Muscular Dystrophy, Scleroatonic Late Onset Scleroatonic Familial Myopathy Congenital Muscular Dystrophy, Ullrich Type
Myofibrillar Myopathy	Desmin Related Myopathy Myotilinopathy Myopathy, Myofibrillar Alpha Beta Crystallinopathy Desmin Storage Myopathy Desminopathy Filaminopathy Protein Surplus Myopathy Zaspopathy Myofibrillar Myopathies Myopathy, Myofibrillar, Desmin-Related Myopathy, Desmin Storage Mfm - [Myofibrillar Myopathy]
Autosomal Recessive Limb-Girdle Muscular Dystrophy	Muscular Dystrophy, Limb-Girdle, Autosomal Recessive
Myopathy	Muscular Diseases Myopathies
Cardiomyopathy, Familial Hypertrophic, 1	Asymmetric Septal Hypertrophy Familial Hypertrophic Cardiomyopathy Hypertrophic Cardiomyopathy 1 CMH1 Hypertrophic Cardiomyopathy 19 CMH Ventricular Hypertrophy, Hereditary Ash Hypertrophic Subaortic Stenosis, Idiopathic Cardiomyopathy, Familial Hypertrophic Cardiomyopathy, Hypertrophic, 1, Digenic Cardiomyopathy, Familial Hypertrophic 1 Hcm Hereditary Ventricular Hypertrophy Idiopathic Hypertrophic Subaortic Stenosis Hypertrophic Cardiomyopathy Cardiomyopathy, Hypertrophic, Familial Cardiomyopathy, Hypertrophic, 1 Familial Asymmetric Septal Hypertrophy Heritable Hypertrophic Cardiomyopathy Fhc Cardiomyopathy, Hypertrophic, Familial, Type 1
Dilated Cardiomyopathy	Familial Dilated Cardiomyopathy Primary Dilated Cardiomyopathy Idiopathic Dilated Cardiomyopathy Congestive Cardiomyopathy Idiopathic Dilation Cardiomyopathy Primary Familial Dilated Cardiomyopathy Cardiomyopathy, Dilated DCM Cardiomyopathy, Familial Dilated Dilated Cardiomyopathy, Familial Hypokinetic Dilated Cardiomyopathy, Familial Familial Idiopathic Cardiomyopathy Fdc Cardiomyopathy, Familial Idiopathic Idiopathic Cardiomegaly Dilated Congestive Cardiomyopathy Chronic Dilated Cardiomyopathy Ccm - [Congestive Cardiomyopathy] Cocm - [Congestive Cardiomyopathy] Dcm - [Dilated Cardiomyopathy] Dilated-Hypokinetic Cardiomyopathy Congestive Idiopathic Cardiomyopathy Primary Idiopathic Dilated Cardiomyopathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15063	TRIM63 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TRIM63	MGD	MGI:2447992
Rattus norvegicus	TRIM63	RGD	RGD:619964
Canis familiaris	TRIM63	VGNC	VGNC:47831
Macaca mulatta	TRIM63	VGNC	VGNC:79002
Felis catus	TRIM63	VGNC	VGNC:66548
Bos taurus	TRIM63	VGNC	VGNC:36346
Others	TRIM63	NCBI