MRPL41 - mitochondrial ribosomal protein L41 Gene

Also Known as BMRP; PIG3; MRPL27; RPML27; MRP-L27

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 64975

About MRPL41

Cytogenetic location: 9q34.3 Genomic coordinates (GRCh38): 9:137,551,879-137,552,555 (from NCBI)

This gene has 1 transcript (splice variant) and 191 orthologues. Broad expression in fat (RPKM 57.1), colon (RPKM 44.9) and 24 other tissues.

Summary

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the YmL27 ribosomal protein family. [provided by RefSeq, Jul 2008]

MRPL41 Products (1)

mRNA Protein Name
NM_032477.3 NP_115866.1 39S ribosomal protein L41, mitochondrial

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
18157088 GOA
enables structural constituent of ribosome IDA
IDA: Inferred from direct assay
16024796 GOA
Biological Process GO Annotation Evidence References Source
involved in translation IDA
IDA: Inferred from direct assay
16024796 GOA
Cellular Component GO Annotation Evidence References Source
part of mitochondrial large ribosomal subunit IDA
IDA: Inferred from direct assay
16024796 GOA
located in mitochondrion IDA
IDA: Inferred from direct assay
28892042 GOA
part of ribonucleoprotein complex IDA
IDA: Inferred from direct assay
16024796 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MRPL41 Protein Structure

MRP-L27

MRP-L27: Mitochondrial ribosomal protein L27 (13 - 127)

  • 0
  • 100
  • 137 a.a.
Protein Preferred Names Protein Names

39S ribosomal protein L41, mitochondrial

  • 39S ribosomal protein L27 homolog

MRPL41 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MRPL41 Q8IXM3 TRIM63 Homo sapiens Q969Q1
Pull Down
18157088
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08672 MRPL41 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus MRPL41 VGNC VGNC:31637
Canis familiaris MRPL41 VGNC VGNC:43398
Felis catus MRPL41 VGNC VGNC:63605
Mus musculus MRPL41 MGD MGI:1333816
Macaca mulatta MRPL41 VGNC VGNC:103277
Rattus norvegicus MRPL41 RGD RGD:1310241
Others MRPL41 NCBI