ORC6 - origin recognition complex subunit 6 Gene

Also Known as ORC6L

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23594

About ORC6

Cytogenetic location: 16q11.2 Genomic coordinates (GRCh38): 16:46,689,659-46,698,394 (from NCBI)

This gene has 9 transcripts (splice variants), 173 orthologues and is associated with 3 phenotypes. Broad expression in testis (RPKM 6.8), bone marrow (RPKM 5.0) and 16 other tissues.

Summary

The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Gene silencing studies with small interfering RNA demonstrated that this protein plays an essential role in coordinating chromosome replication and segregation with cytokinesis. [provided by RefSeq, Oct 2010]

ORC6 Products (1)

mRNA Protein Name
NM_014321.4 NP_055136.1 origin recognition complex subunit 6

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15232106 GOA
Biological Process GO Annotation Evidence References Source
involved in DNA replication initiation IDA
IDA: Inferred from direct assay
16549788 GOA
Cellular Component GO Annotation Evidence References Source
part of nuclear origin of replication recognition complex IPI
IPI: Inferred from physical interaction
16549788 GOA
part of origin recognition complex IDA
IDA: Inferred from direct assay
17716973 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ORC6 Protein Structure

ORC6

ORC6: Origin recognition complex subunit 6 (ORC6) (8 - 94)

  • 0
  • 100
  • 200
  • 252 a.a.
Protein Preferred Names Protein Names

origin recognition complex subunit 6

ORC6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ORC6 Q9Y5N6 LHX4 Homo sapiens Q969G2
Y2H Array
32296183
Intra
ORC6 Q9Y5N6 LHX4 Homo sapiens Q969G2
Y2H Array
31515488
Intra
ORC6 Q9Y5N6 LHX4 Homo sapiens Q969G2
Validated Y2H
25416956
Intra
ORC6 Q9Y5N6 LHX4 Homo sapiens Q969G2
Y2H Prey Pooling
32296183
Intra
ORC6 Q9Y5N6 ORC4 Homo sapiens O43929
Protein Array
15232106
Intra
ORC6 Q9Y5N6 ORC3 Homo sapiens Q9UBD5
Pull Down
17716973
Intra
ORC6 Q9Y5N6 ORC3 Homo sapiens Q9UBD5
Protein Array
15232106
Intra
ORC6 Q9Y5N6 SPAG5 Homo sapiens Q96R06
Y2H Prey Pooling
25416956
Intra
ORC6 Q9Y5N6 SPAG5 Homo sapiens Q96R06
Validated Y2H
25416956
Intra
ORC6 Q9Y5N6 HMGA1 Homo sapiens P17096
Anti Bait CoIP
18234858
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Meier-Gorlin Syndrome 3

  • MGORS3

  • Meier-Gorlin Syndrome, Type 3
Meier-Gorlin Syndrome 1

  • Meier-Gorlin Syndrome

  • Ear, Patella, Short Stature Syndrome

  • Microtia, Absent Patellae, Micrognathia Syndrome

  • MGORS1

  • Eps

  • Ear-Patella-Short Stature Syndrome

  • Ear Patella Short Stature Syndrome

  • Microtia Absent Patellae Micrognathia Syndrome

  • Meier-Gorlin Syndrome, Type 1
Meier-Gorlin Syndrome 7

  • MGORS7

  • Meier-Gorlin Syndrome, Type 7
Meier-Gorlin Syndrome 5

  • MGORS5

  • Meier-Gorlin Syndrome, Type 5
Microtia

  • Congenital Small Ears

  • Hypoplasia Of Ear
Genitourinary Tract Anomalies
Isolated Growth Hormone Deficiency

  • Congenital Ighd

  • Congenital Isolated Gh Deficiency

  • Congenital Isolated Growth Hormone Deficiency

  • Non-Acquired Isolated Growth Hormone Deficiency

  • Pituitary Dwarfism

  • Dwarfism, Pituitary

  • Isolated Somatotropin Deficiency

  • Isolated Congenital Growth Hormone Deficiency

  • Familial Isolated Growth Hormone Deficiency

  • Ighd

  • Dwarfism, Growth Hormone Deficiency

  • Growth Hormone Deficiency Dwarfism

  • Isolated Gh Deficiency

  • Isolated Hgh Deficiency

  • Isolated Human Growth Hormone Deficiency

  • Isolated Somatotropin Deficiency Disorder

  • Dwarfism Pituitary
Isolated Growth Hormone Deficiency, Type Ia

  • Ighd Ia

  • Primordial Dwarfism

  • Isolated Growth Hormone Deficiency Type Ia

  • Sexual Ateleiotic Dwarfism

  • Pituitary Dwarfism I

  • IGHD1A

  • Illig-Type Growth Hormone Deficiency

  • Growth Hormone Deficiency, Isolated, Type Ia

  • Congenital Ighd Type Ia

  • Congenital Isolated Gh Deficiency Type Ia

  • Congenital Isolated Growth Hormone Deficiency Type Ia

  • Pituitary Dwarfism 1

  • Growth Hormone Deficiency, Isolated, Autosomal Recessive

  • Autosomal Recessive Isolated Growth Hormone Deficiency

  • Isolated Growth Hormone Deficiency Type 1a

  • Congenital Ighd

  • Congenital Isolated Gh Deficiency

  • Congenital Isolated Growth Hormone Deficiency

  • Growth Hormone Deficiency, Isolated Autosomal Recessive

  • Illig Type Growth Hormone Deficiency

  • Non-Acquired Isolated Growth Hormone Deficiency

  • Growth Hormone Deficiency, Isolated, 1a

  • Growth Hormone Deficiency Isolated Autosomal Recessive

  • Dwarfism, Primordial

  • Dwarfism
Seckel Syndrome

  • Microcephalic Primordial Dwarfism

  • Bird-Headed Dwarfism

  • Harper'S Syndrome

  • Virchow-Seckel Dwarfism

  • Nanocephalic Dwarfism

  • Sckl

  • Seckel-Type Dwarfism
Microcephaly

  • Microencephaly

  • Microcephalus

  • Microcephalic

  • Nanocephaly

  • Congenital Microcephaly

  • Brain Hypoplasia

  • Brain Nondevelopment

  • Cephalic Hypoplasia

  • Undeveloped Cerebrum

  • Undeveloped Brain

  • Micrencephalon

  • Micrencephaly
Congenital Nervous System Abnormality

  • Congenital Neurologic Anomaly

  • Congenital Nervous System Disorder
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09830 ORC6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus ORC6 VGNC VGNC:32451
Mus musculus ORC6 MGD MGI:1929285
Macaca mulatta ORC6 VGNC VGNC:75637
Felis catus ORC6 VGNC VGNC:63973
Canis familiaris ORC6 VGNC VGNC:44145
Rattus norvegicus ORC6 RGD RGD:1311437
Others ORC6 NCBI