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ORC3 - origin recognition complex subunit 3 Gene

Also Known as LAT; ORC3L; LATHEO

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23595

About ORC3

Cytogenetic location: 6q15 Genomic coordinates (GRCh38): 6:87,590,135-87,677,823 (from NCBI)

This gene has 7 transcripts (splice variants) and 201 orthologues. Ubiquitous expression in testis (RPKM 9.4), adrenal (RPKM 6.1) and 25 other tissues.

Summary

The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Studies of a similar gene in Drosophila suggested a possible role of this protein in neuronal proliferation and olfactory memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008]

ORC3 Products (3)

mRNA	Protein	Name
NM_001197259.2	NP_001184188.1	origin recognition complex subunit 3 isoform 3
NM_012381.4	NP_036513.2	origin recognition complex subunit 3 isoform 2
NM_181837.3	NP_862820.1	origin recognition complex subunit 3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15232106	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA replication initiation	IDA IDA: Inferred from direct assay	16549788	GOA
involved in regulation of DNA replication	IDA IDA: Inferred from direct assay	31160578	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in chromatin	IDA IDA: Inferred from direct assay	31160578	GOA
part of nuclear origin of replication recognition complex	IDA IDA: Inferred from direct assay	20932478	GOA
part of nuclear origin of replication recognition complex	IPI IPI: Inferred from physical interaction	16549788	GOA
part of origin recognition complex	IDA IDA: Inferred from direct assay	17716973	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ORC3 Protein Structure

ORC3_N

0
200
400
600
711 a.a.

Protein Preferred Names	Protein Names
origin recognition complex subunit 3	homolog of latheo, Drosophila

ORC3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ORC3	Q9UBD5	ORC6	Homo sapiens	Q9Y5N6	Anti Bait CoIP	17716973
Intra	ORC3	Q9UBD5	ORC1	Homo sapiens	Q13415	Anti Bait CoIP	17716973
Intra	ORC3	Q9UBD5	ORC4	Homo sapiens	O43929	Anti Bait CoIP	17716973
Intra	ORC3	Q9UBD5	ORC5	Homo sapiens	O43913	Protein Array	15232106
Intra	ORC3	Q9UBD5	ORC5	Homo sapiens	O43913	Anti Bait CoIP	17716973
Intra	ORC3	Q9UBD5	ORC2	Homo sapiens	Q13416	Anti Bait CoIP	17716973

Cross: Cross-species interaction Intra: Intraspecies interaction

ORC3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P89629	ORC3 Antibody (YA8973)	WB, ICC/IF, IF-Tissue, IHC-P, IP	human

Related Diseases

Diseases	Alias
Van Esch-O'Driscoll Syndrome	X-Linked Intellectual Disability, Van Esch Type VEODS Mrxsveod Mental Retardation, X-Linked, Syndromic, Van Esch-O'Driscoll Type X-Linked Syndromic Mental Retardation Van Esch-O'Driscoll Type
Meier-Gorlin Syndrome 1	Meier-Gorlin Syndrome Ear, Patella, Short Stature Syndrome Microtia, Absent Patellae, Micrognathia Syndrome MGORS1 Eps Ear-Patella-Short Stature Syndrome Ear Patella Short Stature Syndrome Microtia Absent Patellae Micrognathia Syndrome Meier-Gorlin Syndrome, Type 1
Isolated Growth Hormone Deficiency, Type Ia	Ighd Ia Primordial Dwarfism Isolated Growth Hormone Deficiency Type Ia Sexual Ateleiotic Dwarfism Pituitary Dwarfism I IGHD1A Illig-Type Growth Hormone Deficiency Growth Hormone Deficiency, Isolated, Type Ia Congenital Ighd Type Ia Congenital Isolated Gh Deficiency Type Ia Congenital Isolated Growth Hormone Deficiency Type Ia Pituitary Dwarfism 1 Growth Hormone Deficiency, Isolated, Autosomal Recessive Autosomal Recessive Isolated Growth Hormone Deficiency Isolated Growth Hormone Deficiency Type 1a Congenital Ighd Congenital Isolated Gh Deficiency Congenital Isolated Growth Hormone Deficiency Growth Hormone Deficiency, Isolated Autosomal Recessive Illig Type Growth Hormone Deficiency Non-Acquired Isolated Growth Hormone Deficiency Growth Hormone Deficiency, Isolated, 1a Growth Hormone Deficiency Isolated Autosomal Recessive Dwarfism, Primordial Dwarfism

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09827	ORC3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20789	Orc3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27303	Orc3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ORC3	VGNC	VGNC:32448
Mus musculus	ORC3	MGD	MGI:1354944
Canis familiaris	ORC3	VGNC	VGNC:44142
Rattus norvegicus	ORC3	RGD	RGD:1308457
Felis catus	ORC3	VGNC	VGNC:68650
Macaca mulatta	ORC3	VGNC	VGNC:75715
Others	ORC3	NCBI