ORC3 - origin recognition complex subunit 3 Gene

Homo sapiens

Also known as LAT; ORC3L; LATHEO

Gene ID: 23595 | Gene type: protein coding

About ORC3

Cytogenetic location: 6q15 Genomic coordinates (GRCh38): 6:87,590,135-87,677,823 (from NCBI)

This gene has 7 transcripts (splice variants) and 201 orthologues. Ubiquitous expression in testis (RPKM 9.4), adrenal (RPKM 6.1) and 25 other tissues.

Summary

The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Studies of a similar gene in Drosophila suggested a possible role of this protein in neuronal proliferation and olfactory memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008]

ORC3 Products(3)

mRNA	Protein	Name
NM_001197259.2	NP_001184188.1	origin recognition complex subunit 3 isoform 3
NM_012381.4	NP_036513.2	origin recognition complex subunit 3 isoform 2
NM_181837.3	NP_862820.1	origin recognition complex subunit 3 isoform 1

ORC3 Protein Structure

ORC3_N

0
200
400
600
711 a.a.

Protein Preferred Names

Protein Names

origin recognition complex subunit 3

homolog of latheo, Drosophila

Related Diseases

Diseases

Alias

Van Esch-O'Driscoll Syndrome

X-Linked Intellectual Disability, Van Esch Type	VEODS
Mrxsveod	Mental Retardation, X-Linked, Syndromic, Van Esch-O'Driscoll Type
X-Linked Syndromic Mental Retardation Van Esch-O'Driscoll Type

Meier-Gorlin Syndrome 1

Meier-Gorlin Syndrome	Ear, Patella, Short Stature Syndrome
Microtia, Absent Patellae, Micrognathia Syndrome	MGORS1
Eps	Ear-Patella-Short Stature Syndrome
Ear Patella Short Stature Syndrome	Microtia Absent Patellae Micrognathia Syndrome
Meier-Gorlin Syndrome, Type 1

Isolated Growth Hormone Deficiency, Type Ia

Ighd Ia	Primordial Dwarfism
Isolated Growth Hormone Deficiency Type Ia	Sexual Ateleiotic Dwarfism
Pituitary Dwarfism I	IGHD1A
Illig-Type Growth Hormone Deficiency	Growth Hormone Deficiency, Isolated, Type Ia
Congenital Ighd Type Ia	Congenital Isolated Gh Deficiency Type Ia
Congenital Isolated Growth Hormone Deficiency Type Ia	Pituitary Dwarfism 1
Growth Hormone Deficiency, Isolated, Autosomal Recessive	Autosomal Recessive Isolated Growth Hormone Deficiency
Isolated Growth Hormone Deficiency Type 1a	Congenital Ighd
Congenital Isolated Gh Deficiency	Congenital Isolated Growth Hormone Deficiency
Growth Hormone Deficiency, Isolated Autosomal Recessive	Illig Type Growth Hormone Deficiency
Non-Acquired Isolated Growth Hormone Deficiency	Growth Hormone Deficiency, Isolated, 1a
Growth Hormone Deficiency Isolated Autosomal Recessive	Dwarfism, Primordial
Dwarfism

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09827	ORC3 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ORC3	VGNC	VGNC:32448
Mus musculus	ORC3	MGD	MGI:1354944
Canis familiaris	ORC3	VGNC	VGNC:44142
Rattus norvegicus	ORC3	RGD	RGD:1308457
Felis catus	ORC3	VGNC	VGNC:68650
Macaca mulatta	ORC3	VGNC	VGNC:75715
Others	ORC3	NCBI