ORC1 - origin recognition complex subunit 1 Gene

Also Known as ORC1L; PARC1; HSORC1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4998

About ORC1

Cytogenetic location: 1p32.3 Genomic coordinates (GRCh38): 1:52,372,829-52,409,503 (from NCBI)

This gene has 2 transcripts (splice variants), 198 orthologues, 1 paralogue and is associated with 3 phenotypes. Biased expression in bone marrow (RPKM 7.3), lymph node (RPKM 2.5) and 10 other tissues.

Summary

The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is the largest subunit of the ORC complex. While Other ORC subunits are stable throughout the cell cycle, the levels of this protein vary during the cell cycle, which has been shown to be controlled by ubiquitin-mediated proteolysis after initiation of DNA replication. This protein is found to be selectively phosphorylated during Mitosis. It is also reported to interact with MYST Histone Acetyltransferase 2 (MyST2/HBO1), a protein involved in control of transcription silencing. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

ORC1 Products (3)

mRNA	Protein	Name
NM_001190818.2	NP_001177747.1	origin recognition complex subunit 1 isoform 1
NM_001190819.2	NP_001177748.1	origin recognition complex subunit 1 isoform 2
NM_004153.4	NP_004144.2	origin recognition complex subunit 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11931757	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA replication initiation	IDA IDA: Inferred from direct assay	16549788	GOA

Cellular Component GO Annotation	Evidence	References	Source
colocalizes with chromosome, telomeric region	IDA IDA: Inferred from direct assay	24270157	GOA
part of nuclear origin of replication recognition complex	IDA IDA: Inferred from direct assay	20932478	GOA
part of nuclear origin of replication recognition complex	IPI IPI: Inferred from physical interaction	16549788	GOA
part of origin recognition complex	IDA IDA: Inferred from direct assay	17716973	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ORC1 Protein Structure

BAH

AAA

Cdc6_C

0
200
400
600
800
861 a.a.

Protein Preferred Names	Protein Names
origin recognition complex subunit 1	origin recognition complex, subunit 1 homolog

ORC1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ORC1	Q13415	ORC3	Homo sapiens	Q9UBD5	Pull Down	17716973
Intra	ORC1	Q13415	ORC3	Homo sapiens	Q9UBD5	Protein Array	15232106
Intra	ORC1	Q13415	ORC3	Homo sapiens	Q9UBD5	Anti Tag CoIP	16549788
Intra	ORC1	Q13415	ORC3	Homo sapiens	Q9UBD5	Anti Tag CoIP	22398447
Intra	ORC1	Q13415	ORC3	Homo sapiens	Q9UBD5	Anti Tag CoIP	17716973
Intra	ORC1	Q13415	ORC3	Homo sapiens	Q9UBD5	Density Sedimentation	16549788
Intra	ORC1	Q13415	ORC5	Homo sapiens	O43913	Density Sedimentation	16549788
Intra	ORC1	Q13415	ORC5	Homo sapiens	O43913	Anti Tag CoIP	22398447
Intra	ORC1	Q13415	ORC5	Homo sapiens	O43913	Anti Tag CoIP	17716973
Intra	ORC1	Q13415	ORC5	Homo sapiens	O43913	Protein Array	15232106
Intra	ORC1	Q13415	ORC5	Homo sapiens	O43913	Anti Tag CoIP	16549788
Intra	ORC1	Q13415	ORC5	Homo sapiens	O43913	Pull Down	17716973
Intra	ORC1	Q13415	ORC5	Homo sapiens	O43913	Anti Tag CoIP	26496610
Intra	ORC1	Q13415	ORC2	Homo sapiens	Q13416	Anti Tag CoIP	16549788
Intra	ORC1	Q13415	ORC2	Homo sapiens	Q13416	CoIP	11931757
Intra	ORC1	Q13415	ORC2	Homo sapiens	Q13416	Anti Tag CoIP	26496610
Intra	ORC1	Q13415	ORC2	Homo sapiens	Q13416	Pull Down	17716973
Intra	ORC1	Q13415	ORC2	Homo sapiens	Q13416	Density Sedimentation	16549788
Intra	ORC1	Q13415	ORC2	Homo sapiens	Q13416	Anti Tag CoIP	17716973
Intra	ORC1	Q13415	ORC2	Homo sapiens	Q13416	Protein Array	15232106
Intra	ORC1	Q13415	ORC2	Homo sapiens	Q13416	Anti Tag CoIP	22398447
Intra	ORC1	Q13415	SKP2	Homo sapiens	Q13309	Pull Down	11931757
Intra	ORC1	Q13415	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Prey Pooling	32296183
Intra	ORC1	Q13415	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Array	32296183
Intra	ORC1	Q13415	TERF2	Homo sapiens	Q15554	Pull Down	16799465
Cross	ORC1	Q13415	EBNA1	Epstein-Barr virus	P03211	Pull Down	18946490

Cross: Cross-species interaction Intra: Intraspecies interaction

ORC1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P810904	ORC1 Antibody	WB, IHC-P	Human, Mouse, Rat
HY-P89845	ORC1 Antibody (YA9189)	WB, IP	human

Related Diseases

Diseases	Alias
Meier-Gorlin Syndrome 1	Meier-Gorlin Syndrome Ear, Patella, Short Stature Syndrome Microtia, Absent Patellae, Micrognathia Syndrome MGORS1 Eps Ear-Patella-Short Stature Syndrome Ear Patella Short Stature Syndrome Microtia Absent Patellae Micrognathia Syndrome Meier-Gorlin Syndrome, Type 1
Microtia	Congenital Small Ears Hypoplasia Of Ear
Genitourinary Tract Anomalies
Humeroradial Synostosis	Humero-Radial Fusion Humero-Radial Synostosis Ramer Ladda Syndrome
Malaria	Malaria, Susceptibility To Malaria, Resistance To Malaria, Cerebral Cerebral Malaria Malaria, Severe, Susceptibility To Malaria, Severe, Resistance To Malaria, Cerebral, Susceptibility To Induced Malaria Malaria, Vivax, Protection Against Malaria, Severe Malaria, Cerebral, Reduced Risk Of Malaria, Protection Against Resistance To Malaria Due To G6pd Deficiency Malaria Due To G6pd Deficiency Malarial Encephalitis CM Malaria Cerebral Susceptibility To Malaria Acute Pernicious Fever Aestivo-Autumnal Fever Aestivo Autumnal Malaria Chagres Fever Continued Malaria Fever Estivo-Autumnal Fever Estivo-Autumnal Malaria Estivo-Autumnal Malarial Fever Falciparum Fever Malignant Tertian Fever Malignant Tertian Malaria Pernicious Intermittent Fever Pernicious Malaria Quotidian Malaria Subtertian Fever Subtertian Malaria Fever Subtertian Malignant Tertian Malaria Tropical Malaria Algid Malaria Bilious Haemoglobinuric Fever Black Water Fever Blackwater Fever Malarial Blackwater Fever Severe Malarial Falciparum West African Fever Malarial Haematinuria Haemoglobinuric Fever Haemoglobinuric Malaria Severe Plasmodium Falciparum Malaria Malarial Haemoglobinuria Malarial Haematuria Falciparum Malaria [Malignant Tertian] Malaria Tropica Malarial Shock Chagres Virus Disease Malignant Malaria Mtm - [Malignant Tertian Malaria] Tm -[Malignant Tertian Malaria] Panama Fever St - [Subtertian Malaria] Malarial Quotidian Benign Tertian Malaria Tertian Ague Vivax Fever Plasmodium Vivax Malaria Nos Btm - [Benign Tertian Malaria] Bt - [Benign Tertian Malaria] Vivax Malaria Benign Tertian Vivax Malaria Tertian Malaria Quartan Malaria Quartan Ague Quartan Fever Plasmodium Malariae Malaria Nos Quartan Malarial Malaria By Plasmodium Malariae Malariae Malaria Ovale Tertian Malaria Plasmodium Ovale Fever Malaria Fever By Plasmodium Ovale Ovale Malaria Malaria By Plasmodium Ovale Malarial Ovale Marsh Fever Remittent Congestive Fever Coastal Fever Remittent Gastric Fever Miasmatic Fever Congestive Remittent Fever Intermittent Fever Jungle Fever Paludism Cameroon Fever Ague Corsican Fever Intermittent Bilious Fever Disease Due To Plasmodiidae Malarial Fever Plasmodiosis Remittent Fever Roman Fever Malaria Fever Nos Malaria Nos Paludal Fever Clinically Diagnosed Malaria Clinically Diagnosed Malaria Without Parasitological Confirmation Congestive Fever Malarial Cachexia Marsh Cachexia Paludal Cachexia Recurrent Malaria Remittent Malaria
Isolated Growth Hormone Deficiency, Type Ia	Ighd Ia Primordial Dwarfism Isolated Growth Hormone Deficiency Type Ia Sexual Ateleiotic Dwarfism Pituitary Dwarfism I IGHD1A Illig-Type Growth Hormone Deficiency Growth Hormone Deficiency, Isolated, Type Ia Congenital Ighd Type Ia Congenital Isolated Gh Deficiency Type Ia Congenital Isolated Growth Hormone Deficiency Type Ia Pituitary Dwarfism 1 Growth Hormone Deficiency, Isolated, Autosomal Recessive Autosomal Recessive Isolated Growth Hormone Deficiency Isolated Growth Hormone Deficiency Type 1a Congenital Ighd Congenital Isolated Gh Deficiency Congenital Isolated Growth Hormone Deficiency Growth Hormone Deficiency, Isolated Autosomal Recessive Illig Type Growth Hormone Deficiency Non-Acquired Isolated Growth Hormone Deficiency Growth Hormone Deficiency, Isolated, 1a Growth Hormone Deficiency Isolated Autosomal Recessive Dwarfism, Primordial Dwarfism
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09825	ORC1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS13095	SLC25A15 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20788	Orc1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27302	Orc1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ORC1	MGD	MGI:1328337
Rattus norvegicus	ORC1	RGD	RGD:631435
Felis catus	ORC1	VGNC	VGNC:68648
Canis familiaris	ORC1	VGNC	VGNC:44140
Bos taurus	ORC1	VGNC	VGNC:32446
Macaca mulatta	ORC1	VGNC	VGNC:106463
Others	ORC1	NCBI