ORC5 - origin recognition complex subunit 5 Gene

Also Known as ORC5L; ORC5P; ORC5T; PPP1R117

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5001

About ORC5

Cytogenetic location: 7q22.1-q22.2 Genomic coordinates (GRCh38): 7:104,126,341-104,208,013 (from NCBI)

This gene has 8 transcripts (splice variants) and 205 orthologues. Ubiquitous expression in testis (RPKM 5.7), prostate (RPKM 4.4) and 25 other tissues.

Summary

The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Oct 2010]

ORC5 Products (2)

mRNA Protein Name
NM_002553.4 NP_002544.1 origin recognition complex subunit 5 isoform 1
NM_181747.4 NP_859531.1 origin recognition complex subunit 5 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15232106 GOA
Biological Process GO Annotation Evidence References Source
involved in DNA replication initiation IDA
IDA: Inferred from direct assay
16549788 GOA
involved in regulation of DNA replication IDA
IDA: Inferred from direct assay
31160578 GOA
Cellular Component GO Annotation Evidence References Source
located in chromatin IDA
IDA: Inferred from direct assay
31160578 GOA
part of nuclear origin of replication recognition complex IDA
IDA: Inferred from direct assay
20932478 GOA
part of nuclear origin of replication recognition complex IPI
IPI: Inferred from physical interaction
16549788 GOA
part of origin recognition complex IDA
IDA: Inferred from direct assay
17716973 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ORC5 Protein Structure

AAA_16

AAA_16: AAA ATPase domain (9 - 147)

ORC5_C

ORC5_C: Origin recognition complex (ORC) subunit 5 C-terminus (177 - 432)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 435 a.a.
Protein Preferred Names Protein Names

origin recognition complex subunit 5

  • protein phosphatase 1, regulatory subunit 117

ORC5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ORC5 O43913 ORC1 Homo sapiens Q13415
Pull Down
17716973
Intra
ORC5 O43913 ORC4 Homo sapiens O43929
Anti Bait CoIP
17716973
Intra
ORC5 O43913 ORC4 Homo sapiens O43929
Protein Array
15232106
Intra
ORC5 O43913 ORC3 Homo sapiens Q9UBD5
Anti Bait CoIP
17716973
Intra
ORC5 O43913 ORC2 Homo sapiens Q13416
Anti Bait CoIP
17716973
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Meier-Gorlin Syndrome 1

  • Meier-Gorlin Syndrome

  • Ear, Patella, Short Stature Syndrome

  • Microtia, Absent Patellae, Micrognathia Syndrome

  • MGORS1

  • Eps

  • Ear-Patella-Short Stature Syndrome

  • Ear Patella Short Stature Syndrome

  • Microtia Absent Patellae Micrognathia Syndrome

  • Meier-Gorlin Syndrome, Type 1
Isolated Growth Hormone Deficiency, Type Ia

  • Ighd Ia

  • Primordial Dwarfism

  • Isolated Growth Hormone Deficiency Type Ia

  • Sexual Ateleiotic Dwarfism

  • Pituitary Dwarfism I

  • IGHD1A

  • Illig-Type Growth Hormone Deficiency

  • Growth Hormone Deficiency, Isolated, Type Ia

  • Congenital Ighd Type Ia

  • Congenital Isolated Gh Deficiency Type Ia

  • Congenital Isolated Growth Hormone Deficiency Type Ia

  • Pituitary Dwarfism 1

  • Growth Hormone Deficiency, Isolated, Autosomal Recessive

  • Autosomal Recessive Isolated Growth Hormone Deficiency

  • Isolated Growth Hormone Deficiency Type 1a

  • Congenital Ighd

  • Congenital Isolated Gh Deficiency

  • Congenital Isolated Growth Hormone Deficiency

  • Growth Hormone Deficiency, Isolated Autosomal Recessive

  • Illig Type Growth Hormone Deficiency

  • Non-Acquired Isolated Growth Hormone Deficiency

  • Growth Hormone Deficiency, Isolated, 1a

  • Growth Hormone Deficiency Isolated Autosomal Recessive

  • Dwarfism, Primordial

  • Dwarfism
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09829 ORC5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris ORC5 VGNC VGNC:44144
Rattus norvegicus ORC5 RGD RGD:1561088
Mus musculus ORC5 MGD MGI:1347044
Felis catus ORC5 VGNC VGNC:68652
Bos taurus ORC5 VGNC VGNC:32450
Macaca mulatta ORC5 VGNC VGNC:75717
Others ORC5 NCBI