ORC2 - origin recognition complex subunit 2 Gene

Homo sapiens

Also known as ORC2L

Gene ID: 4999 | Gene type: protein coding

About ORC2

Cytogenetic location: 2q33.1 Genomic coordinates (GRCh38): 2:200,908,977-200,963,660 (from NCBI)

This gene has 7 transcripts (splice variants) and 197 orthologues. Ubiquitous expression in testis (RPKM 10.9), thyroid (RPKM 5.8) and 25 other tissues.

Summary

The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. This protein forms a core complex with ORC3, -4, and -5. It also interacts with CDC45 and MCM10, which are proteins known to be important for the initiation of DNA replication. This protein has been demonstrated to specifically associate with the origin of replication of Epstein-Barr virus in human cells, and is thought to be required for DNA replication from viral origin of replication. Alternatively spliced transcript variants have been found, one of which is a nonsense-mediated mRNA decay candidate. [provided by RefSeq, Oct 2010]

ORC2 Products(1)

mRNA	Protein	Name
NM_006190.5	NP_006181.1	origin recognition complex subunit 2

ORC2 Protein Structure

ORC2

0
100
200
300
400
500
577 a.a.

Protein Preferred Names

Protein Names

origin recognition complex subunit 2

origin recognition complex protein 2 homolog

Related Diseases

Diseases

Alias

T-Cell Immunodeficiency With Thymic Aplasia

Nezelof Syndrome	T-Lymphocyte Deficiency
TIDTA	Immune Defect Due To Absence Of Thymus
Thymic Aplasia	Nezelof'S Syndrome
Thymic Dysplasia With Normal Immunoglobulins	Thymic Aplasia Syndrome
T-Lymphocyte Immunodeficiency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09826	ORC2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ORC2	VGNC	VGNC:68649
Mus musculus	ORC2	MGD	MGI:1328306
Macaca mulatta	ORC2	VGNC	VGNC:75714
Rattus norvegicus	ORC2	RGD	RGD:1311844
Bos taurus	ORC2	VGNC	VGNC:32447
Canis familiaris	ORC2	VGNC	VGNC:44141