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ORC2 - origin recognition complex subunit 2 Gene

Also Known as ORC2L

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4999

About ORC2

Cytogenetic location: 2q33.1 Genomic coordinates (GRCh38): 2:200,908,977-200,963,660 (from NCBI)

This gene has 7 transcripts (splice variants) and 197 orthologues. Ubiquitous expression in testis (RPKM 10.9), thyroid (RPKM 5.8) and 25 other tissues.

Summary

The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. This protein forms a core complex with ORC3, -4, and -5. It also interacts with CDC45 and MCM10, which are proteins known to be important for the initiation of DNA replication. This protein has been demonstrated to specifically associate with the origin of replication of Epstein-Barr virus in human cells, and is thought to be required for DNA replication from viral origin of replication. Alternatively spliced transcript variants have been found, one of which is a nonsense-mediated mRNA decay candidate. [provided by RefSeq, Oct 2010]

ORC2 Products (1)

mRNA	Protein	Name
NM_006190.5	NP_006181.1	origin recognition complex subunit 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11095689	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA replication initiation	IDA IDA: Inferred from direct assay	16549788	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in centrosome	IDA IDA: Inferred from direct assay	15215892	GOA
colocalizes with chromosome, telomeric region	IDA IDA: Inferred from direct assay	24270157	GOA
located in heterochromatin	IDA IDA: Inferred from direct assay	15215892	GOA
part of nuclear origin of replication recognition complex	IDA IDA: Inferred from direct assay	20932478	GOA
part of nuclear origin of replication recognition complex	IPI IPI: Inferred from physical interaction	16549788	GOA
located in nucleus	IDA IDA: Inferred from direct assay	21383955	GOA
part of origin recognition complex	IDA IDA: Inferred from direct assay	17716973	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ORC2 Protein Structure

ORC2

0
100
200
300
400
500
577 a.a.

Protein Preferred Names	Protein Names
origin recognition complex subunit 2	origin recognition complex protein 2 homolog

ORC2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ORC2	Q13416	CTNNA3	Homo sapiens	Q9UI47-2	Validated Y2H	32296183
Intra	ORC2	Q13416	RAD18	Homo sapiens	Q9NS91	Validated Y2H	32296183
Intra	ORC2	Q13416	ORC1	Homo sapiens	Q13415	Anti Tag CoIP	26496610
Intra	ORC2	Q13416	ORC1	Homo sapiens	Q13415	Pull Down	17716973
Intra	ORC2	Q13416	ORC1	Homo sapiens	Q13415	CoIP	11931757
Intra	ORC2	Q13416	ORC1	Homo sapiens	Q13415	Anti Tag CoIP	16549788
Intra	ORC2	Q13416	CDC5L	Homo sapiens	Q99459	Protein Array	15232106
Intra	ORC2	Q13416	ORC4	Homo sapiens	O43929	Protein Array	15232106
Intra	ORC2	Q13416	ORC4	Homo sapiens	O43929	Anti Tag CoIP	16549788
Intra	ORC2	Q13416	ORC4	Homo sapiens	O43929	Pull Down	17716973
Intra	ORC2	Q13416	ORC4	Homo sapiens	O43929	MAPPIT	31467278
Intra	ORC2	Q13416	ORC4	Homo sapiens	O43929	Density Sedimentation	16549788
Intra	ORC2	Q13416	MCM10	Homo sapiens	Q7L590	Anti Tag CoIP	11095689
Intra	ORC2	Q13416	MCM10	Homo sapiens	Q7L590	Protein Array	15232106
Intra	ORC2	Q13416	MCM10	Homo sapiens	Q7L590	Confocal	11095689
Intra	ORC2	Q13416	ORC3	Homo sapiens	Q9UBD5	Pull Down	17716973
Intra	ORC2	Q13416	ORC3	Homo sapiens	Q9UBD5	Density Sedimentation	16549788
Intra	ORC2	Q13416	ORC3	Homo sapiens	Q9UBD5	Anti Tag CoIP	16549788
Intra	ORC2	Q13416	ORC5	Homo sapiens	O43913	Protein Array	15232106
Intra	ORC2	Q13416	ORC5	Homo sapiens	O43913	Anti Tag CoIP	16549788
Intra	ORC2	Q13416	ORC5	Homo sapiens	O43913	Anti Tag CoIP	26496610
Intra	ORC2	Q13416	ORC5	Homo sapiens	O43913	Density Sedimentation	16549788
Intra	ORC2	Q13416	ORC5	Homo sapiens	O43913	Pull Down	17716973
Intra	ORC2	Q13416	TERF2	Homo sapiens	Q15554	Pull Down	16799465
Intra	ORC2	Q13416	FOXM1	Homo sapiens	Q08050	Pull Down	25609649
Cross	ORC2	Q13416	EBNA1	Epstein-Barr virus	P03211	Anti Bait CoIP	18946490

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
T-Cell Immunodeficiency With Thymic Aplasia	Nezelof Syndrome T-Lymphocyte Deficiency TIDTA Immune Defect Due To Absence Of Thymus Thymic Aplasia Nezelof'S Syndrome Thymic Dysplasia With Normal Immunoglobulins Thymic Aplasia Syndrome T-Lymphocyte Immunodeficiency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-180157	CDK2-IN-51	Inhibitor	/	Unkown
HY-RS09826	ORC2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS13100	SLC25A2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ORC2	VGNC	VGNC:68649
Mus musculus	ORC2	MGD	MGI:1328306
Macaca mulatta	ORC2	VGNC	VGNC:75714
Rattus norvegicus	ORC2	RGD	RGD:1311844
Bos taurus	ORC2	VGNC	VGNC:32447
Canis familiaris	ORC2	VGNC	VGNC:44141
Others	ORC2	NCBI