RAD18 - RAD18 E3 ubiquitin protein ligase Gene

Also Known as RNF73

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 56852

About RAD18

Cytogenetic location: 3p25.3 Genomic coordinates (GRCh38): 3:8,877,075-8,963,472 (from NCBI)

This gene has 10 transcripts (splice variants) and 199 orthologues. Ubiquitous expression in duodenum (RPKM 3.3), lymph node (RPKM 2.7) and 25 other tissues.

Summary

The protein encoded by this gene is highly similar to S. cerevisiae DNA damage repair protein Rad18. Yeast Rad18 functions through its interaction with Rad6, which is an ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Similar to its yeast counterpart, this protein is able to interact with the human homolog of yeast Rad6 protein through a conserved ring-finger motif. Mutation of this motif results in defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens. [provided by RefSeq, Jul 2008]

RAD18 Products (1)

mRNA Protein Name
NM_020165.4 NP_064550.3 E3 ubiquitin-protein ligase RAD18

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables Y-form DNA binding IDA
IDA: Inferred from direct assay
18363965 GOA
enables identical protein binding IDA
IDA: Inferred from direct assay
25023518 GOA
enables polyubiquitin modification-dependent protein binding IDA
IDA: Inferred from direct assay
22742833 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
18316726 GOA
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
25931565 GOA
enables ubiquitin protein ligase binding IPI
IPI: Inferred from physical interaction
10908344 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of or within DNA damage response IDA
IDA: Inferred from direct assay
25023518 GOA
involved in DNA damage response IDA
IDA: Inferred from direct assay
22036607 GOA
involved in positive regulation of chromosome segregation IMP
IMP: Inferred from mutant phenotype
25931565 GOA
acts upstream of or within protein autoubiquitination IDA
IDA: Inferred from direct assay
25023518 GOA
Cellular Component GO Annotation Evidence References Source
located in centrosome IDA
IDA: Inferred from direct assay
15632077 GOA
located in nuclear inclusion body IDA
IDA: Inferred from direct assay
22036607 GOA
located in nucleus IDA
IDA: Inferred from direct assay
15632077 GOA
located in replication fork IDA
IDA: Inferred from direct assay
18363965 GOA
located in site of double-strand break IDA
IDA: Inferred from direct assay
25931565 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAD18 Protein Structure

zf-C3HC4

zf-C3HC4: Zinc finger, C3HC4 type (RING finger) (25 - 63)

SAP

SAP: SAP domain (248 - 281)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 495 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase RAD18

  • RAD18 homolog

RAD18 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RAD18 Q9NS91 HLTF Homo sapiens Q14527
Anti Tag CoIP
18719106
Intra
RAD18 Q9NS91 UBE2A Homo sapiens P49459
TAP
24981860
Intra
RAD18 Q9NS91 UBE2A Homo sapiens P49459
Anti Tag CoIP
26496610
Intra
RAD18 Q9NS91 ARRDC3 Homo sapiens Q96B67
Y2H Prey Pooling
32296183
Intra
RAD18 Q9NS91 ARRDC3 Homo sapiens Q96B67
Y2H Array
32296183
Intra
RAD18 Q9NS91 ORC2 Homo sapiens Q13416
Y2H Array
32296183
Intra
RAD18 Q9NS91 ORC2 Homo sapiens Q13416
Y2H Prey Pooling
32296183
Intra
RAD18 Q9NS91 TAX1BP1 Homo sapiens Q86VP1
Validated Y2H
25416956
Intra
RAD18 Q9NS91 TAX1BP1 Homo sapiens Q86VP1
Y2H Array
25416956
Intra
RAD18 Q9NS91 TAX1BP1 Homo sapiens Q86VP1
Y2H Array
32296183
Intra
RAD18 Q9NS91 TAX1BP1 Homo sapiens Q86VP1
Y2H Prey Pooling
32296183
Intra
RAD18 Q9NS91 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
Intra
RAD18 Q9NS91 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
Intra
RAD18 Q9NS91 UBE2B Homo sapiens P63146
Y2H Array
19549727
Intra
RAD18 Q9NS91 UBE2B Homo sapiens P63146
Y2H
19549727
Intra
RAD18 Q9NS91 DAZAP2 Homo sapiens Q15038
Y2H Prey Pooling
32296183
Intra
RAD18 Q9NS91 DAZAP2 Homo sapiens Q15038
Y2H Array
32296183
Intra
RAD18 Q9NS91 MAGEA4 Homo sapiens P43358
Y2H Prey Pooling
32296183
Intra
RAD18 Q9NS91 MAGEA4 Homo sapiens P43358
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

RAD18 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83322 Rad18 Antibody (YA3067) WB, FC Human, Mouse, Rat

Related Diseases

Diseases Alias
Xeroderma Pigmentosum, Variant Type

  • Xeroderma Pigmentosum

  • XPV

  • Xeroderma Pigmentosum Variant Type

  • Xeroderma Pigmentosum With Normal Dna Repair Rates

  • Photosensitivity With Defective Dna Synthesis

  • Xp

  • De Sanctis-Cacchione Syndrome

  • Desanctis-Cacchione Syndrome

  • Xeroderma Pigmentosa

  • Xerodermic Idiocy

  • Xeroderma Pigmentosum Variant

  • Xp - [Xeroderma Pigmentosum]

  • Atrophoderma Pigmentosum
Cornelia De Lange Syndrome

  • De Lange Syndrome

  • Brachmann De Lange Syndrome

  • Brachmann-De Lange Syndrome

  • Cdls

  • Bdls

  • Typus Degenerativus Amstelodamensis
Aplastic Anemia

  • Aplastic Anemia, Susceptibility To

  • Anemia Aplastic

  • Idiopathic Aplastic Anemia

  • Secondary Aplastic Anemia

  • Idiopathic Bone Marrow Failure

  • Aplastic Anemia Idiopathic

  • AA

  • Anemia, Aplastic

  • Aplastic Anemia, Idiopathic

  • Erythroid Aplasia

  • Aa - [Aplastic Anaemia]

  • Haematopoietic Aplasia

  • Aleukia Haemorrhagica

  • Anaemia Due To Decreased Red Cell Production

  • Aplasia Bone Marrow

  • Aplastic Bone Marrow

  • Hypoplastic Anaemia Nos

  • Myeloid Bone Marrow Aplasia

  • Pancytopenia

  • Panhaematopenia

  • Hypoproliferative Anaemia

  • Medullary Hypoplasia

  • Red Blood Cells Hypoplastic Anaemia

  • Panmyelophthisis

  • Panhemocytopenia

  • Refractive Hypoproliferative Anaemia

  • Toxic Anaemia

  • Toxic Aplastic Anaemia

  • Aplastic Anaemia Due To Toxic Cause

  • Idiopathic Aplastic Anaemia Nos
Fanconi Anemia, Complementation Group A

  • Fanconi Anemia

  • Fanconi Pancytopenia

  • Fanconi Anemia Complementation Group A

  • FANCA

  • Fa

  • Fanconi Panmyelopathy

  • Fanconi'S Anemia

  • Fanconi Anaemia

  • Fanconi'S Anaemia

  • Fanconi Hypoplastic Anemia

  • Estren-Dameshek Variant Of Fanconi Anemia

  • Estren-Dameshek Variant Of Fanconi Pancytopenia

  • Fanconi Anemia Estren-Dameshek Variant

  • Fanconis Anemia
Seckel Syndrome

  • Microcephalic Primordial Dwarfism

  • Bird-Headed Dwarfism

  • Harper'S Syndrome

  • Virchow-Seckel Dwarfism

  • Nanocephalic Dwarfism

  • Sckl

  • Seckel-Type Dwarfism
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P11621 JWP24 Inhibitor / Unkown
HY-RS11598 RAD18 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris RAD18 VGNC VGNC:45312
Mus musculus RAD18 MGD MGI:1890476
Rattus norvegicus RAD18 RGD RGD:1306993
Macaca mulatta RAD18 VGNC VGNC:76508
Felis catus RAD18 VGNC VGNC:64477
Bos taurus RAD18 VGNC VGNC:33679
Others RAD18 NCBI