2. Metabolic Enzyme/Protease
  3. E1/E2/E3 Enzyme
  4. JWP24

JWP24 is the first cell membrane-permeable peptide inhibitor of MAGE-A4, with an IC50 of 200 nM against human MAGE-A4. JWP24 binds to intracellular targets while retaining binding activity, disrupts the interaction between MAGE-A4 and RAD18, and does not induce cytotoxicity at effective concentrations. JWP24 is applicable for cancer-related research.

For research use only. We do not sell to patients.

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JWP24

JWP24 Chemical Structure

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JWP24 Related Antibodies

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Description

JWP24 is the first cell membrane-permeable peptide inhibitor of MAGE-A4, with an IC50 of 200 nM against human MAGE-A4. JWP24 binds to intracellular targets while retaining binding activity, disrupts the interaction between MAGE-A4 and RAD18, and does not induce cytotoxicity at effective concentrations. JWP24 is applicable for cancer-related research[1].

IC50 & Target

RAD18

 

In Vitro

JWP24 (0.005-80 μM; 1.5 h) potently disrupts the interaction between MAGE-A4 and RAD18 in HEK293 cells, with an IC50 of 0.5 μM, and exhibits no cytotoxicity at effective concentrations[1].
JWP24 (10 μM; 2 h) inhibits the interaction between MAGE-A4 and RAD18 in H1299 cell lysates[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

JWP24 Related Antibodies

Western Blot Analysis[1]

Cell Line: H1299 cells (transiently transfected with plasmids expressing Myc-RAD18 and HA-MAGE-A4)
Concentration: 10 μM
Incubation Time: 2 h
Result: Bound to the conserved MHD of MAGE-A4 and effectively inhibit the MAGE-A4/RAD18 interaction.
Molecular Weight

1349.64

Formula

C68H89FN12O12S2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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JWP24 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JWP24JWP 24JWP-24E1/E2/E3 EnzymeE1 activating enzymeE2 conjugating enzymeE3 ligating enzymeUbiquitin activating enzymeUbiquitin conjugating enzymeUbiquitin ligasePAMPA assayRAD18MAGE-A4H1299 cell lysatesTR-FRET assaycell-free assaycancerHEK293 cellsInhibitorinhibitorinhibit

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