CDC5L - cell division cycle 5 like Gene

Homo sapiens

Also known as CDC5; CEF1; PCDC5RP; CDC5-LIKE; dJ319D22.1

Gene ID: 988 | Gene type: protein coding

About CDC5L

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:44,387,706-44,450,425 (from NCBI)

Ubiquitous expression in testis (RPKM 9.6), bone marrow (RPKM 8.1) and 25 other tissues.

Summary

The protein encoded by this gene shares a significant similarity with Schizosaccharomyces pombe cdc5 gene product, which is a cell cycle regulator important for G2/M transition. This protein has been demonstrated to act as a positive regulator of cell cycle G2/M progression. It was also found to be an essential component of a non-snRNA spliceosome, which contains at least five additional protein factors and is required for the second catalytic step of pre-mRNA splicing. [provided by RefSeq, Jul 2008]

CDC5L Products(1)

mRNA	Protein	Name
NM_001253.4	NP_001244.1	cell division cycle 5-like protein

CDC5L Protein Structure

Myb_DNA-bind_6

Myb_Cef

0
200
400
600
802 a.a.

Protein Preferred Names

Protein Names

cell division cycle 5-like protein

CDC5 cell division cycle 5-like

Related Diseases

Diseases

Alias

Renal Dysplasia

Kidney Dysplasia	Renal Cell Dysplasia
Congenital Renal Dysplasia	Dysplasia Of Kidney
Dysplastic Kidney

Poikiloderma With Neutropenia

Poikiloderma With Neutropenia, Clericuzio Type	PN
Clericuzio Type Poikiloderma With Neutropenia	Poikiloderma With Neutropenia, Clericuzio-Type
Clericuzio-Type Poikiloderma With Neutropenia	Poikiloderma With Neutropenia Clericuzio Type
Immune-Deficient Poikiloderma	Clericuzio-Type Poikiloderma Neutropenia Syndrome
Poikiloderma With Neutropenia Clericuzio-Type	Poikiloderma, With Neutropenia

Hepatic Adenomas, Familial

Hepatic Adenoma, Somatic	Familial Hepatic Adenoma
Familial Liver Cell Adenomas	Liver Cell Adenomas, Familial
Hepatic Adenomas Familial	HEPAF
Ha	Hepatocellular Adenomas
Hepatocellular Adenoma

Atrial Septal Defect 1

ASD1	Atrial Heart Septal Defect 1
Asd

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Cakut

Renal Or Urinary Tract Malformation	Congenital Anomalies Of Kidney And Urinary Tract
Congenital Anomaly Of Kidney And Urinary Tract	Congenital Anomalies Of The Kidney And Urinary Tract
Kidney And Urinary Tract, Anomalies, Congenital	Renal Hypodysplasia, Nonsyndromic, 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15339	CVT-313	Inhibitor	99.76%	Unkown
HY-RS02307	CDC5L Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CDC5L	MGD	MGI:1918952
Bos taurus	CDC5L	VGNC	VGNC:27080
Felis catus	CDC5L	VGNC	VGNC:60663
Rattus norvegicus	CDC5L	RGD	RGD:70892
Macaca mulatta	CDC5L	VGNC	VGNC:70801
Canis familiaris	CDC5L	VGNC	VGNC:39008

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