PLRG1 - pleiotropic regulator 1 Gene

Homo sapiens

Also known as Cwc1; PRL1; PRP46; PRPF46; TANGO4

Gene ID: 5356 | Gene type: protein coding

About PLRG1

Cytogenetic location: 4q31.3 Genomic coordinates (GRCh38): 4:154,535,005-154,550,400 (from NCBI)

This gene has 13 transcripts (splice variants) and 219 orthologues. Ubiquitous expression in thyroid (RPKM 15.5), brain (RPKM 13.3) and 25 other tissues.

Summary

This gene encodes a core component of the cell division cycle 5-like (CDC5L) complex. The CDC5L complex is part of the spliceosome and is required for pre-mRNA splicing. The encoded protein plays a critical role in alternative splice site selection. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

PLRG1 Products(2)

mRNA	Protein	Name
NM_001201564.2	NP_001188493.1	pleiotropic regulator 1 isoform 2
NM_002669.4	NP_002660.1	pleiotropic regulator 1 isoform 1

PLRG1 Protein Structure

WD40

0
100
200
300
400
514 a.a.

Protein Preferred Names

Protein Names

pleiotropic regulator 1

pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)

Related Diseases

Diseases

Alias

Poikiloderma With Neutropenia

Poikiloderma With Neutropenia, Clericuzio Type	PN
Clericuzio Type Poikiloderma With Neutropenia	Poikiloderma With Neutropenia, Clericuzio-Type
Clericuzio-Type Poikiloderma With Neutropenia	Poikiloderma With Neutropenia Clericuzio Type
Immune-Deficient Poikiloderma	Clericuzio-Type Poikiloderma Neutropenia Syndrome
Poikiloderma With Neutropenia Clericuzio-Type	Poikiloderma, With Neutropenia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10738	PLRG1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PLRG1	MGD	MGI:1858197
Rattus norvegicus	PLRG1	RGD	RGD:621047
Bos taurus	PLRG1	VGNC	VGNC:33050
Macaca mulatta	PLRG1	VGNC	VGNC:76180
Canis familiaris	PLRG1	VGNC	VGNC:44710
Felis catus	PLRG1	VGNC	VGNC:68911

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