PRPF19 - pre-mRNA processing factor 19 Gene

Also Known as PSO4; SNEV; PRP19; UBOX4; hPSO4; NMP200

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 27339

About PRPF19

Cytogenetic location: 11q12.2 Genomic coordinates (GRCh38): 11:60,890,547-60,906,585 (from NCBI)

This gene has 7 transcripts (splice variants), 219 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 44.9), ovary (RPKM 35.1) and 25 other tissues.

Summary

PSO4 is the human homolog of yeast Pso4, a gene essential for cell survival and DNA repair (Beck et al., 2008 [PubMed 18263876]).[supplied by OMIM, Sep 2008]

PRPF19 Products (1)

mRNA Protein Name
NM_014502.5 NP_055317.1 pre-mRNA-processing factor 19

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
16332694 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
19188445 GOA
enables ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
11435423 GOA
enables ubiquitin protein ligase activity IMP
IMP: Inferred from mutant phenotype
20595234 GOA
enables ubiquitin-ubiquitin ligase activity IDA
IDA: Inferred from direct assay
11435423 GOA
Biological Process GO Annotation Evidence References Source
involved in DNA damage checkpoint signaling IMP
IMP: Inferred from mutant phenotype
24332808 GOA
involved in double-strand break repair via nonhomologous end joining IMP
IMP: Inferred from mutant phenotype
18263876 GOA
involved in mRNA splicing, via spliceosome IDA
IDA: Inferred from direct assay
20176811 GOA
involved in proteasomal protein catabolic process IMP
IMP: Inferred from mutant phenotype
17349974 GOA
involved in protein K63-linked ubiquitination IMP
IMP: Inferred from mutant phenotype
20595234 GOA
involved in protein localization IMP
IMP: Inferred from mutant phenotype
18263876 GOA
acts upstream of or within protein polyubiquitination IDA
IDA: Inferred from direct assay
11435423 GOA
involved in spliceosomal complex assembly IMP
IMP: Inferred from mutant phenotype
16332694 GOA
involved in spliceosomal tri-snRNP complex assembly IDA
IDA: Inferred from direct assay
20595234 GOA
Cellular Component GO Annotation Evidence References Source
part of DNA replication factor A complex IDA
IDA: Inferred from direct assay
24332808 GOA
part of Prp19 complex IDA
IDA: Inferred from direct assay
20176811 GOA
part of Prp19 complex IPI
IPI: Inferred from physical interaction
20176811 GOA
part of U2-type catalytic step 2 spliceosome IDA
IDA: Inferred from direct assay
28076346 GOA
part of catalytic step 2 spliceosome IDA
IDA: Inferred from direct assay
11991638 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
11435423 GOA
located in nuclear speck IDA
IDA: Inferred from direct assay
16332694 GOA
located in nucleus IDA
IDA: Inferred from direct assay
11435423 GOA
located in site of double-strand break IDA
IDA: Inferred from direct assay
18263876 GOA
part of spliceosomal complex IPI
IPI: Inferred from physical interaction
20176811 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRPF19 Protein Structure

U-box

U-box: U-box domain (3 - 54)

Prp19

Prp19: Prp19/Pso4-like (67 - 134)

WD40

WD40: WD domain, G-beta repeat (256 - 292)

WD40

WD40: WD domain, G-beta repeat (297 - 327)

WD40

WD40: WD domain, G-beta repeat (353 - 378)

WD40

WD40: WD domain, G-beta repeat (384 - 420)

WD40

WD40: WD domain, G-beta repeat (466 - 503)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 504 a.a.
Protein Preferred Names Protein Names

pre-mRNA-processing factor 19

  • PRP19/PSO4 homolog

PRPF19 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PRPF19 Q9UMS4 BCAS2 Homo sapiens O75934
Anti Tag CoIP
22365833
Intra
PRPF19 Q9UMS4 BCAS2 Homo sapiens O75934
Anti Tag CoIP
35271311
Intra
PRPF19 Q9UMS4 BCAS2 Homo sapiens O75934
Far-WB
20176811
Intra
PRPF19 Q9UMS4 BCAS2 Homo sapiens O75934
Anti Tag CoIP
28514442
Intra
PRPF19 Q9UMS4 PLRG1 Homo sapiens O43660
Anti Tag CoIP
35271311
Intra
PRPF19 Q9UMS4 CDC40 Homo sapiens O60508
Anti Tag CoIP
33961781
Intra
PRPF19 Q9UMS4 CDC40 Homo sapiens O60508
Anti Tag CoIP
28514442
Intra
PRPF19 Q9UMS4 CDC40 Homo sapiens O60508
Anti Tag CoIP
22365833
Intra
PRPF19 Q9UMS4 CDC5L Homo sapiens Q99459
Pull Down
20176811
Intra
PRPF19 Q9UMS4 CDC5L Homo sapiens Q99459
Anti Tag CoIP
35271311
Intra
PRPF19 Q9UMS4 CDC5L Homo sapiens Q99459
Anti Tag CoIP
33961781
Intra
PRPF19 Q9UMS4 CDC5L Homo sapiens Q99459
Anti Tag CoIP
28514442
Intra
PRPF19 Q9UMS4 CDC5L Homo sapiens Q99459
Pull Down
19633697
Intra
PRPF19 Q9UMS4 CDC5L Homo sapiens Q99459
Far-WB
20176811
Intra
PRPF19 Q9UMS4 PRPF8 Homo sapiens Q6P2Q9
Anti Tag CoIP
33961781
Intra
PRPF19 Q9UMS4 RBM5 Homo sapiens P52756
Anti Tag CoIP
22569250
Cross: Cross-species interaction Intra: Intraspecies interaction

PRPF19 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83313 PRPF19 Antibody (YA3058) WB, IHC-P, ICC/IF, FC Human, Mouse, Rat

Related Diseases

Diseases Alias
Poikiloderma With Neutropenia

  • Poikiloderma With Neutropenia, Clericuzio Type

  • PN

  • Clericuzio Type Poikiloderma With Neutropenia

  • Poikiloderma With Neutropenia, Clericuzio-Type

  • Clericuzio-Type Poikiloderma With Neutropenia

  • Poikiloderma With Neutropenia Clericuzio Type

  • Immune-Deficient Poikiloderma

  • Clericuzio-Type Poikiloderma Neutropenia Syndrome

  • Poikiloderma With Neutropenia Clericuzio-Type

  • Poikiloderma, With Neutropenia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11206 PRPF19 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus PRPF19 VGNC VGNC:33372
Canis familiaris PRPF19 VGNC VGNC:45019
Rattus norvegicus PRPF19 RGD RGD:708496
Mus musculus PRPF19 MGD MGI:106247
Felis catus PRPF19 VGNC VGNC:64369
Macaca mulatta PRPF19 VGNC VGNC:76281
Others PRPF19 NCBI