RBM5 - RNA binding motif protein 5 Gene

Also Known as G15; H37; RMB5; LUCA15; LUCA-15

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10181

About RBM5

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:50,088,919-50,119,021 (from NCBI)

This gene has 26 transcripts (splice variants), 262 orthologues and 2 paralogues. Ubiquitous expression in skin (RPKM 32.9), endometrium (RPKM 30.9) and 25 other tissues.

Summary

This gene is a candidate tumor suppressor gene which encodes a nuclear RNA binding protein that is a component of the spliceosome A complex. The encoded protein plays a role in the induction of cell cycle arrest and Apoptosis through pre-mRNA splicing of multiple target genes including the tumor suppressor protein p53. This gene is located within the tumor suppressor region 3p21.3, and may play a role in the inhibition of tumor transformation and progression of several malignancies including lung Cancer. [provided by RefSeq, Oct 2011]

RBM5 Products (1)

mRNA Protein Name
NM_005778.4 NP_005769.1 RNA-binding protein 5

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables mRNA binding IDA
IDA: Inferred from direct assay
18840686 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
18951082 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of apoptotic process IDA
IDA: Inferred from direct assay
18840686 GOA
involved in regulation of alternative mRNA splicing, via spliceosome IDA
IDA: Inferred from direct assay
18840686 GOA
involved in spliceosomal complex assembly IDA
IDA: Inferred from direct assay
18951082 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
18951082 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RBM5 Protein Structure

(100 - 171)

zf-RanBP

zf-RanBP: Zn-finger in Ran binding protein and others (181 - 209)

(233 - 308)

G-patch

G-patch: G-patch domain (743 - 787)

  • 0
  • 200
  • 400
  • 600
  • 815 a.a.
Protein Preferred Names Protein Names

RNA-binding protein 5

  • putative tumor suppressor LUCA15

RBM5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RBM5 P52756 NEK7 Homo sapiens Q8TDX7
Y2H Pooling
32814053
Intra
RBM5 P52756 NEK7 Homo sapiens Q8TDX7
Validated Y2H
32814053
Intra
RBM5 P52756 NEK7 Homo sapiens Q8TDX7
Y2H Array
32814053
Intra
RBM5 P52756 APOE Homo sapiens P02649
Validated Y2H
32814053
Intra
RBM5 P52756 APOE Homo sapiens P02649
Y2H Array
32814053
Intra
RBM5 P52756 APOE Homo sapiens P02649
Y2H Pooling
32814053
Intra
RBM5 P52756 DHX15 Homo sapiens O43143
Pull Down
22569250
Intra
RBM5 P52756 DHX15 Homo sapiens O43143
Anti Tag CoIP
22569250
Intra
RBM5 P52756 DHX15 Homo sapiens O43143
Anti Bait CoIP
22569250
Intra
RBM5 P52756 MLYCD Homo sapiens O95822-2
Y2H Array
32296183
Intra
RBM5 P52756 MLYCD Homo sapiens O95822-2
Y2H Prey Pooling
32296183
Intra
RBM5 P52756 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
26871637
Intra
RBM5 P52756 MEOX2 Homo sapiens Q6FHY5
Y2H Array
26871637
Intra
RBM5 P52756 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
26871637
Intra
RBM5 P52756 KLK6 Homo sapiens Q92876
Validated Y2H
32814053
Intra
RBM5 P52756 KLK6 Homo sapiens Q92876
Y2H Pooling
32814053
Intra
RBM5 P52756 KLK6 Homo sapiens Q92876
Y2H Array
32814053
Intra
RBM5 P52756 MEOX1 Homo sapiens P50221
Validated Y2H
26871637
Intra
RBM5 P52756 MEOX1 Homo sapiens P50221
Y2H Prey Pooling
26871637
Intra
RBM5 P52756 MEOX1 Homo sapiens P50221
Y2H Array
26871637
Intra
RBM5 P52756 MEOX1 Homo sapiens P50221
BiFC
26871637
Intra
RBM5 P52756 TGFBR2 Homo sapiens P37173
Y2H Pooling
32814053
Intra
RBM5 P52756 TGFBR2 Homo sapiens P37173
Validated Y2H
32814053
Intra
RBM5 P52756 TGFBR2 Homo sapiens P37173
Y2H Array
32814053
Intra
RBM5 P52756 PRPF19 Homo sapiens Q9UMS4
Anti Bait CoIP
22569250
Intra
RBM5 P52756 PRPF19 Homo sapiens Q9UMS4
Anti Tag CoIP
22569250
Intra
RBM5 P52756 PRPF19 Homo sapiens Q9UMS4
Y2H
22365833
Intra
RBM5 P52756 PRPF19 Homo sapiens Q9UMS4
Pull Down
22569250
Intra
RBM5 P52756 PRPF19 Homo sapiens Q9UMS4
Anti Tag CoIP
22365833
Intra
RBM5 P52756 U2AF2 Homo sapiens P26368
Anti Bait CoIP
22569250
Intra
RBM5 P52756 U2AF2 Homo sapiens P26368
Pull Down
22569250
Cross: Cross-species interaction Intra: Intraspecies interaction

RBM5 Antibodies

Cat. No. Product Name Application Reactivity
HY-P811079 G15 Antibody WB, IHC-P Human, Mouse, Rat
HY-P89932 LUCA15 Antibody (YA9276) WB, ICC/IF, IF-Tissue, IP, ELISA human, mouse, rat

Related Diseases

Diseases Alias
Primary Ovarian Insufficiency 6
Tarp Syndrome

  • TARPS

  • Pierre Robin Syndrome With Congenital Heart Malformation And Clubfoot

  • Pierre Robin Sequence-Congenital Heart Defect-Talipes Syndrome

  • Pierre Robin Syndrome-Congenital Heart Defect-Talipes Syndrome

  • Talipes Equinovarus-Atrial Septal Defect-Robin Sequence-Persistence Of The Left Superior Vena Cava Syndrome

  • Talipes Equinovarus, Atrial Septal Defect, Robin Sequence, And Persistence Of Left Superior Vena Cava

  • Pierre Robin Sequence - Congenital Heart Defect - Talipes

  • Pierre Robin Syndrome - Congenital Heart Defect - Talipes

  • Talipes Equinovarus - Atrial Septal Defect - Robin Sequence - Persistence Of The Left Superior Vena Cava

  • Talipes Equinovarus Atrial Septal Defect Robin Sequence And Persistence Of Left Superior Vena Cava
Lung Cancer

  • Lung Carcinoma

  • Non-Small Cell Lung Carcinoma

  • Lung Cancer, Susceptibility To

  • Lung Cancer, Protection Against

  • Adenocarcinoma Of Lung, Somatic

  • Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer

  • Lung Neoplasm

  • Carcinoma Of Lung

  • Lung Non-Small Cell Carcinoma

  • Non-Small Cell Lung Cancer

  • Nsclc

  • Lung Neoplasms

  • Malignant Neoplasm Of Lung

  • Alveolar Cell Carcinoma

  • Nonsmall Cell Lung Cancer, Somatic

  • Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer, Susceptibility To

  • Lung Cancer, Somatic

  • Lung Cancer, Resistance To

  • Cancer Of Lung

  • Cancer Of Bronchus

  • Cancer Of The Lung

  • Lung Malignancies

  • Lung Malignant Tumors

  • Malignant Lung Tumor

  • Malignant Tumor Of Lung

  • Pulmonary Cancer

  • Pulmonary Carcinoma

  • Pulmonary Neoplasms

  • Respiratory Carcinoma

  • LNCR

  • Adenocarcinoma Of Lung

  • Neoplasm Of Lung

  • Cancer Lung

  • Carcinoma Non-Small Cell Lung

  • Carcinoma, Non-Small-Cell Lung

  • Lung Cancers

  • Lung Carcinomas

  • Cancer, Lung

  • Cancer, Lung, Non-Small Cell

  • Primary Malignant Neoplasm Of Lung

  • Bronchioloalveolar Adenocarcinoma
Medulloblastoma Wnt Activated
Medulloblastoma Shh Activated
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS27935 Rbm5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11756 RBM5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21416 Rbm5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus RBM5 MGD MGI:1933204
Canis familiaris RBM5 VGNC VGNC:45424
Felis catus RBM5 VGNC VGNC:69265
Bos taurus RBM5 VGNC VGNC:33806
Macaca mulatta RBM5 VGNC VGNC:76682
Rattus norvegicus RBM5 RGD RGD:1305059
Others RBM5 NCBI