TTF2 - transcription termination factor 2 Gene

Also Known as F2; HuF2; ZGRF6

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8458

About TTF2

Cytogenetic location: 1p13.1 Genomic coordinates (GRCh38): 1:117,060,326-117,107,453 (from NCBI)

This gene has 7 transcripts (splice variants), 99 orthologues and 30 paralogues. Ubiquitous expression in lymph node (RPKM 3.1), appendix (RPKM 2.5) and 25 other tissues.

Summary

This gene encodes a member of the SWI2/SNF2 family of proteins, which play a critical role in altering protein-DNA interactions. The encoded protein has been shown to have dsDNA-dependent ATPase activity and RNA polymerase II termination activity. This protein interacts with cell division cycle 5-like, associates with human splicing complexes, and plays a role in pre-mRNA splicing. [provided by RefSeq, Jul 2008]

TTF2 Products (1)

mRNA Protein Name
NM_003594.4 NP_003585.3 transcription termination factor 2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables ATP-dependent activity, acting on DNA IDA
IDA: Inferred from direct assay
9748214 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
12927788 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TTF2 Protein Structure

zf-GRF

zf-GRF: GRF zinc finger (5 - 39)

SNF2_N

SNF2_N: SNF2 family N-terminal domain (573 - 931)

Helicase_C

Helicase_C: Helicase conserved C-terminal domain (1028 - 1106)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1162 a.a.
Protein Preferred Names Protein Names

transcription termination factor 2

  • RNA polymerase II termination factor

TTF2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TTF2 Q9UNY4 CDC5L Homo sapiens Q99459
Anti Bait CoIP
12927788
Intra
TTF2 Q9UNY4 CDC5L Homo sapiens Q99459
Chromatography
12927788
Cross: Cross-species interaction Intra: Intraspecies interaction

TTF2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82558 Transcription Termination Factor 2 Antibody (YA2303) WB, IHC-F, IHC-P, ICC/IF Human, Rat
HY-P82558A Transcription Termination Factor 2 Antibody (YA2303)(PBS only) WB, IHC-F, IHC-P, ICC/IF Human, Rat

Related Diseases

Diseases Alias
Sexual Sadism

  • Sadism
Narcissistic Personality Disorder
Axenfeld-Rieger Syndrome

  • Axenfeld Syndrome

  • Rieger Syndrome

  • Rieger Anomaly

  • Axenfeld Anomaly

  • Anomaly, Rieger'S

  • Hagedoom Syndrome

  • Rgs - Rieger Syndrome

  • Rieger'S Anomaly

  • Goniodysgenesis Hypodontia

  • Iridogoniodysgenesis With Somatic Anomalies

  • Ars

  • Axenfeld And Rieger Anomaly

  • Axra

  • Axrs

  • Rieger Eye Malformation Sequence
Antisocial Personality Disorder

  • Dissocial Personality Disorder

  • Asocial Personality

  • Psychopath.Personality

  • Psychopathic Personality

  • Psychopathic Personality Disorder

  • Sociopathic Personality
Brunner Syndrome

  • Monoamine Oxidase A Deficiency

  • Antisocial Behavior

  • BRNRS

  • Deficiency Of Monoamine Oxidase A

  • X-Linked Monoamine Oxidase Deficiency

  • Susceptibility To Antisocial Behavior

  • Antisocial Behavior, Susceptibility To

  • Anti-Social Behavior
Congenital Hypothyroidism

  • Cretinism

  • Neonatal Hypothyroidism

  • Ch

  • Cht

  • Congenital Myxedema

  • Myxedema, Congenital

  • Endemic Cretinism

  • Congenital Iodine-Deficiency Syndrome

  • Fetal Iodine Deficiency Syndrome

  • Congenital Iodine-Deficiency Hypothyroidism Nos
Resting Heart Rate, Variation In

  • Resting Heart Rate

  • Rhr

  • Resting Heart Rate, Variation
Charcot-Marie-Tooth Disease

  • Cmt

  • Hmsn

  • Hereditary Motor And Sensory Neuropathy

  • Pma

  • Cmt - Charcot-Marie-Tooth Disease

  • Charcot Marie Tooth Disease

  • Charcot-Marie-Tooth Hereditary Neuropathy

  • Charcot-Marie-Tooth Syndrome

  • Peroneal Muscular Atrophy

  • Hereditary Motor And Sensory Neuropathies
Cerebral Palsy

  • Infantile Cerebral Palsy

  • Mixed Cerebral Palsy

  • Palsy Cerebral

  • Palsy, Cerebral

  • Cerebral Palsy, Mixed
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05047 FOXE1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15223 TTF2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20831 Ttf2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21574 Foxe1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27345 Ttf2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28092 Foxe1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta TTF2 VGNC VGNC:82263
Rattus norvegicus TTF2 RGD RGD:1309145
Canis familiaris TTF2 VGNC VGNC:47968
Mus musculus TTF2 MGD MGI:1921294
Bos taurus TTF2 VGNC VGNC:36484
Felis catus TTF2 VGNC VGNC:66680
Others TTF2 NCBI