MCM10 - minichromosome maintenance 10 replication initiation factor Gene

Also Known as CNA43; DNA43; IMD80; PRO2249

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 55388

About MCM10

Cytogenetic location: 10p13 Genomic coordinates (GRCh38): 10:13,161,558-13,211,110 (from NCBI)

This gene has 7 transcripts (splice variants), 203 orthologues and is associated with 1 phenotype. Broad expression in bone marrow (RPKM 2.8), lymph node (RPKM 2.2) and 15 other tissues.

Summary

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and it may be involved in the formation of replication forks and in the recruitment of Other DNA replication related proteins. This protein can interact with MCM2 and MCM6, as well as with the origin recognition protein ORC2. It is regulated by proteolysis and phosphorylation in a cell cycle-dependent manner. Studies of a similar protein in Xenopus suggest that the chromatin binding of this protein at the onset of DNA replication is after pre-RC assembly and before origin unwinding. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

MCM10 Products (2)

mRNA	Protein	Name
NM_018518.5	NP_060988.3	protein MCM10 homolog isoform 2
NM_182751.3	NP_877428.1	protein MCM10 homolog isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	17823614	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11095689	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA damage response	IMP IMP: Inferred from mutant phenotype	24726359	GOA
involved in DNA replication initiation	IMP IMP: Inferred from mutant phenotype	32865517	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	11095689	GOA
located in nucleus	IMP IMP: Inferred from mutant phenotype	32865517	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MCM10 Protein Structure

zf-primase

Mcm10

0
200
400
600
800
875 a.a.

Protein Preferred Names	Protein Names
protein MCM10 homolog	MCM10 minichromosome maintenance deficient 10

MCM10 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MCM10	Q7L590	MCM6	Homo sapiens	Q14566	Anti Tag CoIP	35271311
Intra	MCM10	Q7L590	MCM6	Homo sapiens	Q14566	Protein Array	15232106
Intra	MCM10	Q7L590	CDC6	Homo sapiens	Q99741	Protein Array	15232106
Intra	MCM10	Q7L590	CDC45	Homo sapiens	O75419	Protein Array	15232106
Intra	MCM10	Q7L590	CEP72	Homo sapiens	Q9P209	Y2H Array	31515488
Intra	MCM10	Q7L590	CDC7	Homo sapiens	O00311	Protein Array	15232106
Intra	MCM10	Q7L590	CDK6	Homo sapiens	Q00534	Protein Array	15232106
Intra	MCM10	Q7L590	ORC2	Homo sapiens	Q13416	Y2H	11095689
Intra	MCM10	Q7L590	CEP72	Homo sapiens	Q9P209	Y2H Pooling	16189514
Intra	MCM10	Q7L590	CCND3	Homo sapiens	P30281	Protein Array	15232106
Intra	MCM10	Q7L590	MCM10	Homo sapiens	Q7L590	GMS	17823614
Intra	MCM10	Q7L590	CDC5L	Homo sapiens	Q99459	Protein Array	15232106
Intra	MCM10	Q7L590	MCM10	Homo sapiens	Q7L590	EM	17823614
Intra	MCM10	Q7L590	CCND1	Homo sapiens	P24385	Protein Array	15232106
Intra	MCM10	Q7L590	ORC2	Homo sapiens	Q13416	Anti Bait CoIP	11095689

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Immunodeficiency 80 With Or Without Congenital Cardiomyopathy	IMD80 Mcm10 Deficiency Immunodeficiency 80 With Or Without Cardiomyopathy
Nk Cell Deficiency
Restrictive Cardiomyopathy	Familial Restrictive Cardiomyopathy Cardiomyopathy, Restrictive Cardiomyopathy, Constrictive Primary Restrictive Cardiomyopathy Rcm Cardiomyopathy Restrictive
Endometrial Mixed Adenocarcinoma
Baller-Gerold Syndrome	BGS Craniosynostosis With Radial Defects Craniosynostosis-Radial Aplasia Syndrome Craniosynostosis Radial Aplasia Syndrome
Rapadilino Syndrome	Absent Thumbs, Dislocated Joints, Long Face With Narrow Palpebral Fissures, Long Slender Nose, Arched Palate Radial And Patellar Aplasia Radial And Patellar Hypoplasia RAPADILINOS
Ovary Serous Adenocarcinoma	Malignant Ovarian Serous Tumor Serous Carcinoma Of Ovary
Filippi Syndrome	Scott Craniodigital Syndrome With Mental Retardation Type 1 Syndactyly-Microcephaly-Intellectual Disability Syndrome FLPIS Scott Bryant Graham Syndrome Craniodigital-Intellectual Disability Syndrome Scott Craniodigital Syndrome Scott-Bryant-Graham Syndrome Syndactyly, Type I, With Microcephaly And Mental Retardation Syndactyly Type I With Microcephaly And Intellectual Disability Unusual Facial Appearance, Microcephaly, Growth And Intellectual Disability And Syndactyly Craniodigital Syndrome With Intellectual Disability Craniodigital Syndrome-Intellectual Disability Syndrome Craniodigital Syndrome-Intellectual Disability, Scott Type Intellectual Disability-Craniodigital Syndrome
Fanconi Anemia, Complementation Group A	Fanconi Anemia Fanconi Pancytopenia Fanconi Anemia Complementation Group A FANCA Fa Fanconi Panmyelopathy Fanconi'S Anemia Fanconi Anaemia Fanconi'S Anaemia Fanconi Hypoplastic Anemia Estren-Dameshek Variant Of Fanconi Anemia Estren-Dameshek Variant Of Fanconi Pancytopenia Fanconi Anemia Estren-Dameshek Variant Fanconis Anemia
Meier-Gorlin Syndrome 1	Meier-Gorlin Syndrome Ear, Patella, Short Stature Syndrome Microtia, Absent Patellae, Micrognathia Syndrome MGORS1 Eps Ear-Patella-Short Stature Syndrome Ear Patella Short Stature Syndrome Microtia Absent Patellae Micrognathia Syndrome Meier-Gorlin Syndrome, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08233	MCM10 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19711	Mcm10 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26207	Mcm10 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	MCM10	VGNC	VGNC:31307
Macaca mulatta	MCM10	VGNC	VGNC:74528
Mus musculus	MCM10	MGD	MGI:1917274
Felis catus	MCM10	VGNC	VGNC:63414
Rattus norvegicus	MCM10	RGD	RGD:1311330
Canis familiaris	MCM10	VGNC	VGNC:43080
Others	MCM10	NCBI