MCM10 - minichromosome maintenance 10 replication initiation factor Gene

Homo sapiens

Also known as CNA43; DNA43; IMD80; PRO2249

Gene ID: 55388 | Gene type: protein coding

About MCM10

Cytogenetic location: 10p13 Genomic coordinates (GRCh38): 10:13,161,558-13,211,110 (from NCBI)

This gene has 7 transcripts (splice variants), 203 orthologues and is associated with 1 phenotype. Broad expression in bone marrow (RPKM 2.8), lymph node (RPKM 2.2) and 15 other tissues.

Summary

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and it may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein can interact with MCM2 and MCM6, as well as with the origin recognition protein ORC2. It is regulated by proteolysis and phosphorylation in a cell cycle-dependent manner. Studies of a similar protein in Xenopus suggest that the chromatin binding of this protein at the onset of DNA replication is after pre-RC assembly and before origin unwinding. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

MCM10 Products(2)

mRNA	Protein	Name
NM_018518.5	NP_060988.3	protein MCM10 homolog isoform 2
NM_182751.3	NP_877428.1	protein MCM10 homolog isoform 1

MCM10 Protein Structure

zf-primase

Mcm10

0
200
400
600
800
875 a.a.

Protein Preferred Names

Protein Names

protein MCM10 homolog

MCM10 minichromosome maintenance deficient 10

Related Diseases

Diseases

Alias

Immunodeficiency 80 With Or Without Congenital Cardiomyopathy

IMD80	Mcm10 Deficiency
Immunodeficiency 80 With Or Without Cardiomyopathy

Nk Cell Deficiency

Restrictive Cardiomyopathy

Familial Restrictive Cardiomyopathy	Cardiomyopathy, Restrictive
Cardiomyopathy, Constrictive	Primary Restrictive Cardiomyopathy
Rcm	Cardiomyopathy Restrictive

Endometrial Mixed Adenocarcinoma

Baller-Gerold Syndrome

BGS	Craniosynostosis With Radial Defects
Craniosynostosis-Radial Aplasia Syndrome	Craniosynostosis Radial Aplasia Syndrome

Rapadilino Syndrome

Absent Thumbs, Dislocated Joints, Long Face With Narrow Palpebral Fissures, Long Slender Nose, Arched Palate	Radial And Patellar Aplasia
Radial And Patellar Hypoplasia	RAPADILINOS

Ovary Serous Adenocarcinoma

Malignant Ovarian Serous Tumor

Serous Carcinoma Of Ovary

Filippi Syndrome

Scott Craniodigital Syndrome With Mental Retardation	Type 1 Syndactyly-Microcephaly-Intellectual Disability Syndrome
FLPIS	Scott Bryant Graham Syndrome
Craniodigital-Intellectual Disability Syndrome	Scott Craniodigital Syndrome
Scott-Bryant-Graham Syndrome	Syndactyly, Type I, With Microcephaly And Mental Retardation
Syndactyly Type I With Microcephaly And Intellectual Disability	Unusual Facial Appearance, Microcephaly, Growth And Intellectual Disability And Syndactyly
Craniodigital Syndrome With Intellectual Disability	Craniodigital Syndrome-Intellectual Disability Syndrome
Craniodigital Syndrome-Intellectual Disability, Scott Type	Intellectual Disability-Craniodigital Syndrome

Fanconi Anemia, Complementation Group A

Fanconi Anemia	Fanconi Pancytopenia
Fanconi Anemia Complementation Group A	FANCA
Fa	Fanconi Panmyelopathy
Fanconi'S Anemia	Fanconi Anaemia
Fanconi'S Anaemia	Fanconi Hypoplastic Anemia
Estren-Dameshek Variant Of Fanconi Anemia	Estren-Dameshek Variant Of Fanconi Pancytopenia
Fanconi Anemia Estren-Dameshek Variant	Fanconis Anemia

Meier-Gorlin Syndrome 1

Meier-Gorlin Syndrome	Ear, Patella, Short Stature Syndrome
Microtia, Absent Patellae, Micrognathia Syndrome	MGORS1
Eps	Ear-Patella-Short Stature Syndrome
Ear Patella Short Stature Syndrome	Microtia Absent Patellae Micrognathia Syndrome
Meier-Gorlin Syndrome, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08233	MCM10 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	MCM10	VGNC	VGNC:31307
Macaca mulatta	MCM10	VGNC	VGNC:74528
Mus musculus	MCM10	MGD	MGI:1917274
Felis catus	MCM10	VGNC	VGNC:63414
Rattus norvegicus	MCM10	RGD	RGD:1311330
Canis familiaris	MCM10	VGNC	VGNC:43080

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