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MCM6 - minichromosome maintenance complex component 6 Gene

Also Known as Mis5; P105MCM; MCG40308

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4175

About MCM6

Cytogenetic location: 2q21.3 Genomic coordinates (GRCh38): 2:135,839,626-135,876,443 (from NCBI)

This gene has 3 transcripts (splice variants), 208 orthologues, 8 paralogues and is associated with 2 phenotypes. Broad expression in lymph node (RPKM 19.9), bone marrow (RPKM 13.7) and 24 other tissues.

Summary

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of Other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of the complex by CDC2 kinase reduces the helicase activity, suggesting a role in the regulation of DNA replication. Single nucleotide polymorphisms in the intron regions of this gene are associated with differential transcriptional activation of the promoter of the neighboring lactase gene and, thereby, influence lactose intolerance in early adulthood. [provided by RefSeq, May 2012]

MCM6 Products (1)

mRNA	Protein	Name
NM_005915.6	NP_005906.2	DNA replication licensing factor MCM6

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
contributes to DNA helicase activity	IDA IDA: Inferred from direct assay	9305914	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	15232106	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11095689	GOA
contributes to single-stranded DNA binding	IDA IDA: Inferred from direct assay	25661590	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA unwinding involved in DNA replication	IDA IDA: Inferred from direct assay	22474384	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of CMG complex	IPI IPI: Inferred from physical interaction	22474384	GOA
part of MCM complex	IDA IDA: Inferred from direct assay	17296731	GOA
part of MCM complex	IPI IPI: Inferred from physical interaction	22540012	GOA
located in nucleus	IDA IDA: Inferred from direct assay	16899510	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MCM6 Protein Structure

MCM_N

MCM

0
200
400
600
821 a.a.

Protein Preferred Names	Protein Names
DNA replication licensing factor MCM6	MCM6 minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe)

MCM6 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MCM6	Q14566	NUDT2	Homo sapiens	P50583	Validated Y2H	25416956
Intra	MCM6	Q14566	UBE3A	Homo sapiens	Q05086-2	Anti Tag CoIP	29426014
Intra	MCM6	Q14566	MCM10	Homo sapiens	Q7L590-2	Y2H Prey Pooling	25416956
Intra	MCM6	Q14566	SNRPB2	Homo sapiens	P08579	Y2H Prey Pooling	25416956
Intra	MCM6	Q14566	SNRPB2	Homo sapiens	P08579	Validated Y2H	25416956
Intra	MCM6	Q14566	SSRP1	Homo sapiens	Q08945	Anti Bait CoIP	16902406
Intra	MCM6	Q14566	MCM3	Homo sapiens	P25205	Anti Tag CoIP	26496610
Intra	MCM6	Q14566	MCM3	Homo sapiens	P25205	TAP	17296731
Intra	MCM6	Q14566	MCM7	Homo sapiens	P33993	Anti Bait CoIP	16438930
Intra	MCM6	Q14566	MCM7	Homo sapiens	P33993	Anti Tag CoIP	26496610
Intra	MCM6	Q14566	MCM7	Homo sapiens	P33993	TAP	17296731
Intra	MCM6	Q14566	MCM2	Homo sapiens	P49736	Validated Y2H	25416956
Intra	MCM6	Q14566	MCM2	Homo sapiens	P49736	Anti Tag CoIP	26496610
Intra	MCM6	Q14566	MCM2	Homo sapiens	P49736	TAP	17296731
Intra	MCM6	Q14566	MCMBP	Homo sapiens	Q9BTE3	TAP	17296731
Intra	MCM6	Q14566	MCMBP	Homo sapiens	Q9BTE3	Anti Bait CoIP	24299456
Intra	MCM6	Q14566	MCMBP	Homo sapiens	Q9BTE3	Anti Bait CoIP	22540012
Intra	MCM6	Q14566	MCM10	Homo sapiens	Q7L590	Y2H Pooling	16189514
Intra	MCM6	Q14566	CDKN2A	Homo sapiens	P42771	Anti Bait CoIP	17955473
Intra	MCM6	Q14566	ZBTB9	Homo sapiens	Q96C00	Y2H Prey Pooling	25416956
Intra	MCM6	Q14566	CDT1	Homo sapiens	Q9H211	Pull Down	20202939
Cross	MCM6	Q14566	q76353_9hiv1	Human immunodeficiency virus	Q76353	Pull Down	22190034
Intra	MCM6	Q14566	FAM161A	Homo sapiens	Q3B820	Y2H Prey Pooling	25416956
Intra	MCM6	Q14566	UBE3A	Homo sapiens	Q05086	Y2H Pooling	21653829
Intra	MCM6	Q14566	UBE3A	Homo sapiens	Q05086	Anti Tag CoIP	21653829

Cross: Cross-species interaction Intra: Intraspecies interaction

MCM6 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81401	MCM6 Antibody (YA1146)	IHC-P	Human
HY-P81401A	MCM6 Antibody (YA1146)(PBS only)	IHC-P	Human

Related Diseases

Diseases	Alias
Lactose Intolerance, Adult Type	Hypolactasia, Adult Type Adult Lactase Deficiency Disaccharide Intolerance Iii Lactase Persistence/Nonpersistence Lactose Intolerance Adult Type
Lactose Intolerance	Lactose Malabsorption Lm - Lactose Malabsorption Alactasia Dairy Product Intolerance Hypolactasia Milk Sugar Intolerance Cow Milk Enteropathy Intolerance Or Malabsorption Of Lactose Lm - [Lactose Malabsorption] Milk Intolerance
Craniopharyngioma	Neoplasm Of Rathke'S Pouch Adamantinomatous Tumor Craniopharyngeal Duct Tumor Dysodontogenic Epithelial Tumor Rathke'S Pouch Tumor
Lactase Deficiency, Congenital	Congenital Lactase Deficiency Disaccharide Intolerance Ii Congenital Alactasia Congenital Alactasia Syndrome Congenital Lactose Intolerance Congenital Lactose Malabsorption Hereditary Alactasia Alactasia, Congenital Cld COLACD Disaccharide Intolerance Type 2 Cld - [Congenital Lactase Deficiency] Disaccharide Intolerance 2 Lactose Intolerance Of Newborn Hereditary Lactase Deficiency
Endometrial Mixed Adenocarcinoma
Filippi Syndrome	Scott Craniodigital Syndrome With Mental Retardation Type 1 Syndactyly-Microcephaly-Intellectual Disability Syndrome FLPIS Scott Bryant Graham Syndrome Craniodigital-Intellectual Disability Syndrome Scott Craniodigital Syndrome Scott-Bryant-Graham Syndrome Syndactyly, Type I, With Microcephaly And Mental Retardation Syndactyly Type I With Microcephaly And Intellectual Disability Unusual Facial Appearance, Microcephaly, Growth And Intellectual Disability And Syndactyly Craniodigital Syndrome With Intellectual Disability Craniodigital Syndrome-Intellectual Disability Syndrome Craniodigital Syndrome-Intellectual Disability, Scott Type Intellectual Disability-Craniodigital Syndrome
Fanconi Anemia, Complementation Group A	Fanconi Anemia Fanconi Pancytopenia Fanconi Anemia Complementation Group A FANCA Fa Fanconi Panmyelopathy Fanconi'S Anemia Fanconi Anaemia Fanconi'S Anaemia Fanconi Hypoplastic Anemia Estren-Dameshek Variant Of Fanconi Anemia Estren-Dameshek Variant Of Fanconi Pancytopenia Fanconi Anemia Estren-Dameshek Variant Fanconis Anemia
Meier-Gorlin Syndrome 1	Meier-Gorlin Syndrome Ear, Patella, Short Stature Syndrome Microtia, Absent Patellae, Micrognathia Syndrome MGORS1 Eps Ear-Patella-Short Stature Syndrome Ear Patella Short Stature Syndrome Microtia Absent Patellae Micrognathia Syndrome Meier-Gorlin Syndrome, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N4148	Purpureaside C	Inducer	99.40%	Unkown
HY-RS08239	MCM6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21372	Mcm6 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27891	Mcm6 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	MCM6	VGNC	VGNC:68217
Rattus norvegicus	MCM6	RGD	RGD:61967
Bos taurus	MCM6	VGNC	VGNC:31312
Mus musculus	MCM6	MGD	MGI:1298227
Canis familiaris	MCM6	VGNC	VGNC:43086
Macaca mulatta	MCM6	VGNC	VGNC:74685
Others	MCM6	NCBI