MCM3 - minichromosome maintenance complex component 3 Gene

Also Known as HCC5; P1.h; RLFB; P1-MCM3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4172

About MCM3

Cytogenetic location: 6p12.2 Genomic coordinates (GRCh38): 6:52,264,015-52,284,742 (from NCBI)

This gene has 6 transcripts (splice variants), 208 orthologues and 8 paralogues. Ubiquitous expression in lymph node (RPKM 33.0), appendix (RPKM 23.5) and 24 other tissues.

Summary

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of Other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2018]

MCM3 Products (9)

mRNA Protein Name
NM_001270472.3 NP_001257401.2 DNA replication licensing factor MCM3 isoform 2
NM_001366369.2 NP_001353298.1 DNA replication licensing factor MCM3 isoform 3
NM_001366370.2 NP_001353299.1 DNA replication licensing factor MCM3 isoform 4
NM_001366371.2 NP_001353300.1 DNA replication licensing factor MCM3 isoform 5
NM_001366372.2 NP_001353301.1 DNA replication licensing factor MCM3 isoform 6
NM_001366373.2 NP_001353302.1 DNA replication licensing factor MCM3 isoform 7
NM_001366374.2 NP_001353303.1 DNA replication licensing factor MCM3 isoform 8
NM_001366375.2 NP_001353304.1 DNA replication licensing factor MCM3 isoform 9
NM_002388.6 NP_002379.4 DNA replication licensing factor MCM3 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12364596 GOA
Biological Process GO Annotation Evidence References Source
involved in DNA unwinding involved in DNA replication IDA
IDA: Inferred from direct assay
22474384 GOA
Cellular Component GO Annotation Evidence References Source
part of CMG complex IPI
IPI: Inferred from physical interaction
22474384 GOA
part of MCM complex IDA
IDA: Inferred from direct assay
17296731 GOA
part of MCM complex IPI
IPI: Inferred from physical interaction
22540012 GOA
NOT located in nucleolus IDA
IDA: Inferred from direct assay
21383955 GOA
located in nucleus IDA
IDA: Inferred from direct assay
20531406 GOA
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
20531406 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MCM3 Protein Structure

MCM_N

MCM_N: MCM N-terminal domain (16 - 129)

MCM

MCM: MCM2/3/5 family (282 - 651)

  • 0
  • 200
  • 400
  • 600
  • 808 a.a.
Protein Preferred Names Protein Names

DNA replication licensing factor MCM3

  • DNA polymerase alpha holoenzyme-associated protein P1

MCM3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MCM3 P25205 MCM5 Homo sapiens P33992
Anti Tag CoIP
28514442
Intra
MCM3 P25205 MCM5 Homo sapiens P33992
Anti Tag CoIP
33961781
Intra
MCM3 P25205 MCM5 Homo sapiens P33992
Density Sedimentation
22540012
Intra
MCM3 P25205 MCM5 Homo sapiens P33992
CoIP
12364596
Intra
MCM3 P25205 MCM2 Homo sapiens P49736
Anti Tag CoIP
33961781
Intra
MCM3 P25205 MCM2 Homo sapiens P49736
Anti Tag CoIP
28514442
Intra
MCM3 P25205 MCM6 Homo sapiens Q14566
Anti Tag CoIP
33961781
Intra
MCM3 P25205 MCM6 Homo sapiens Q14566
Anti Tag CoIP
28514442
Intra
MCM3 P25205 MCM6 Homo sapiens Q14566
Protein Array
15232106
Intra
MCM3 P25205 ORC2 Homo sapiens Q13416
CoIP
12364596
Intra
MCM3 P25205 MCMBP Homo sapiens Q9BTE3
Anti Tag CoIP
33961781
Intra
MCM3 P25205 MCMBP Homo sapiens Q9BTE3
Anti Bait CoIP
22540012
Cross: Cross-species interaction Intra: Intraspecies interaction

MCM3 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81392 MCM3 Antibody (YA1137) IHC-P Human
HY-P81392A MCM3 Antibody (YA1137)(PBS only) IHC-P Human
HY-P84212 MCM3 Antibody (YA3909) WB, IHC-P, ICC/IF, FC Human, Rat, Monkey
HY-P84212A MCM3 Antibody (YA3909)(PBS only) WB, IHC-P, ICC/IF, FC Human, Rat, Monkey

Related Diseases

Diseases Alias
Anaplastic Astrocytoma

  • Grade Iii Astrocytoma

  • Astrocytoma, Anaplastic

  • Grade Iii Astrocytic Tumor
Cervical Cancer

  • Cervical Cancer, Somatic

  • Neoplasm Of Uterine Cervix

  • Cervix Cancer

  • Uterine Cervical Neoplasm

  • Cervical Neoplasm

  • Cervix Uteri Cancer

  • Tumor Of The Cervix Uteri

  • CERCA

  • Uterine Cervical Cancer

  • Neoplasms Cervical

  • Uterine Cervical Neoplasms

  • Cervical Cancers

  • Cancer, Cervical, Somatic

  • Malignant Tumor Of Cervix

  • Cervix Carcinoma
Meier-Gorlin Syndrome 5

  • MGORS5

  • Meier-Gorlin Syndrome, Type 5
Lung Cancer

  • Lung Carcinoma

  • Non-Small Cell Lung Carcinoma

  • Lung Cancer, Susceptibility To

  • Lung Cancer, Protection Against

  • Adenocarcinoma Of Lung, Somatic

  • Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer

  • Lung Neoplasm

  • Carcinoma Of Lung

  • Lung Non-Small Cell Carcinoma

  • Non-Small Cell Lung Cancer

  • Nsclc

  • Lung Neoplasms

  • Malignant Neoplasm Of Lung

  • Alveolar Cell Carcinoma

  • Nonsmall Cell Lung Cancer, Somatic

  • Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer, Susceptibility To

  • Lung Cancer, Somatic

  • Lung Cancer, Resistance To

  • Cancer Of Lung

  • Cancer Of Bronchus

  • Cancer Of The Lung

  • Lung Malignancies

  • Lung Malignant Tumors

  • Malignant Lung Tumor

  • Malignant Tumor Of Lung

  • Pulmonary Cancer

  • Pulmonary Carcinoma

  • Pulmonary Neoplasms

  • Respiratory Carcinoma

  • LNCR

  • Adenocarcinoma Of Lung

  • Neoplasm Of Lung

  • Cancer Lung

  • Carcinoma Non-Small Cell Lung

  • Carcinoma, Non-Small-Cell Lung

  • Lung Cancers

  • Lung Carcinomas

  • Cancer, Lung

  • Cancer, Lung, Non-Small Cell

  • Primary Malignant Neoplasm Of Lung

  • Bronchioloalveolar Adenocarcinoma
Meier-Gorlin Syndrome 1

  • Meier-Gorlin Syndrome

  • Ear, Patella, Short Stature Syndrome

  • Microtia, Absent Patellae, Micrognathia Syndrome

  • MGORS1

  • Eps

  • Ear-Patella-Short Stature Syndrome

  • Ear Patella Short Stature Syndrome

  • Microtia Absent Patellae Micrognathia Syndrome

  • Meier-Gorlin Syndrome, Type 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08235 MCM3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08236 MCM3AP Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus MCM3 MGD MGI:101845
Canis familiaris MCM3 VGNC VGNC:43082
Felis catus MCM3 VGNC VGNC:68213
Macaca mulatta MCM3 VGNC VGNC:74681
Rattus norvegicus MCM3 RGD RGD:1305168
Bos taurus MCM3 VGNC VGNC:31309
Others MCM3 NCBI