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MCM5 - minichromosome maintenance complex component 5 Gene

Also Known as CDC46; MGORS8; P1-CDC46

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4174

About MCM5

Cytogenetic location: 22q12.3 Genomic coordinates (GRCh38): 22:35,400,140-35,455,031 (from NCBI)

This gene has 10 transcripts (splice variants), 204 orthologues, 8 paralogues and is associated with 1 phenotype. Broad expression in bone marrow (RPKM 35.9), lymph node (RPKM 27.6) and 24 other tissues.

Summary

The protein encoded by this gene is structurally very similar to the CDC46 protein from S. cerevisiae, a protein involved in the initiation of DNA replication. The encoded protein is a member of the MCM family of chromatin-binding proteins and can interact with at least two Other members of this family. The encoded protein is upregulated in the transition from the G0 to G1/S phase of the cell cycle and may actively participate in cell cycle regulation. [provided by RefSeq, Jul 2008]

MCM5 Products (1)

mRNA	Protein	Name
NM_006739.4	NP_006730.2	DNA replication licensing factor MCM5

MCM5 Protein Structure

MCM_N

MCM

0
200
400
600
734 a.a.

Protein Preferred Names	Protein Names
DNA replication licensing factor MCM5	CDC46 homolog

MCM5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MCM5	P33992	MCM3	Homo sapiens	P25205	Anti Tag CoIP	33961781
Intra	MCM5	P33992	MCM3	Homo sapiens	P25205	Protein Array	15232106
Intra	MCM5	P33992	MCM7	Homo sapiens	P33993	Anti Tag CoIP	33961781
Intra	MCM5	P33992	MCMBP	Homo sapiens	Q9BTE3	Anti Tag CoIP	33961781
Intra	MCM5	P33992	MCMBP	Homo sapiens	Q9BTE3	Anti Bait CoIP	24299456

Cross: Cross-species interaction Intra: Intraspecies interaction

MCM5 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81395	MCM5 Antibody (YA1140)	IHC-P	Human
HY-P81395A	MCM5 Antibody (YA1140)(PBS only)	IHC-P	Human

Related Diseases

Diseases	Alias
Meier-Gorlin Syndrome 8	MGORS8
Genitourinary Tract Anomalies
Meier-Gorlin Syndrome 7	MGORS7 Meier-Gorlin Syndrome, Type 7
Meier-Gorlin Syndrome 5	MGORS5 Meier-Gorlin Syndrome, Type 5
Melanoacanthoma
Neuropathy, Hereditary Sensory And Autonomic, Type Iii	Familial Dysautonomia Riley-Day Syndrome Dysautonomia, Familial HSAN3 Hsan Iii Fd Hereditary Sensory And Autonomic Neuropathy Type Iii Dys Hereditary Sensory And Autonomic Neuropathy 3 Riley Day Syndrome Familial Autonomic Nervous Dysfunction Hereditary Sensory Autonomic Neuropathy Type Iii Hsan 3 Hsn 3 Hereditary Sensory Neuropathy Type 3 Hsan Type Iii Hsn-Iii Hereditary Sensory And Autonomic Neuropathy Type 3 Neuropathy, Hereditary Sensory And Autonomic, 3 Hsn Iii Dysautonomia Familial Neuropathy, Sensory And Autonomic, Hereditary, Type Iii Hsan3 - [Hereditary Sensory And Autonomic Neuropathy Type 3]
Familial Glucocorticoid Deficiency	Glucocorticoid Deficiency Acth Resistance Adrenal Unresponsiveness To Acth Hereditary Unresponsiveness To Adrenocorticotropic Hormone Isolated Glucocorticoid Deficiency Glucocorticoid Deficiency, Familial Glucocorticoid Deficiency 1
Meier-Gorlin Syndrome 1	Meier-Gorlin Syndrome Ear, Patella, Short Stature Syndrome Microtia, Absent Patellae, Micrognathia Syndrome MGORS1 Eps Ear-Patella-Short Stature Syndrome Ear Patella Short Stature Syndrome Microtia Absent Patellae Micrognathia Syndrome Meier-Gorlin Syndrome, Type 1
Isolated Growth Hormone Deficiency, Type Ia	Ighd Ia Primordial Dwarfism Isolated Growth Hormone Deficiency Type Ia Sexual Ateleiotic Dwarfism Pituitary Dwarfism I IGHD1A Illig-Type Growth Hormone Deficiency Growth Hormone Deficiency, Isolated, Type Ia Congenital Ighd Type Ia Congenital Isolated Gh Deficiency Type Ia Congenital Isolated Growth Hormone Deficiency Type Ia Pituitary Dwarfism 1 Growth Hormone Deficiency, Isolated, Autosomal Recessive Autosomal Recessive Isolated Growth Hormone Deficiency Isolated Growth Hormone Deficiency Type 1a Congenital Ighd Congenital Isolated Gh Deficiency Congenital Isolated Growth Hormone Deficiency Growth Hormone Deficiency, Isolated Autosomal Recessive Illig Type Growth Hormone Deficiency Non-Acquired Isolated Growth Hormone Deficiency Growth Hormone Deficiency, Isolated, 1a Growth Hormone Deficiency Isolated Autosomal Recessive Dwarfism, Primordial Dwarfism
Benign Epilepsy With Centrotemporal Spikes	Rolandic Epilepsy Benign Rolandic Epilepsy Epilepsy, Rolandic Bcects Benign Childhood Epilepsy With Centrotemporal Spike Sylvan Seizures Becrs Bects Bre Benign Epilepsy Of Childhood With Centrotemporal Spikes Benign Familial Epilepsy Of Childhood With Rolandic Spikes Centrotemporal Epilepsy
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-153100A	(S)-mchm5U		98.87%	Unkown
HY-178176	PROTAC CB1R Degrader-1		/	Unkown
HY-RS08238	MCM5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22230	Mcm5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28752	Mcm5 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MCM5	MGD	MGI:103197
Bos taurus	MCM5	VGNC	VGNC:31311
Rattus norvegicus	MCM5	RGD	RGD:1306616
Felis catus	MCM5	VGNC	VGNC:68216
Macaca mulatta	MCM5	VGNC	VGNC:74684
Canis familiaris	MCM5	VGNC	VGNC:43085
Others	MCM5	NCBI