CDK6 - cyclin dependent kinase 6 Gene

Also Known as MCPH12; PLSTIRE

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1021

About CDK6

Cytogenetic location: 7q21.2 Genomic coordinates (GRCh38): 7:92,604,921-92,836,573 (from NCBI)

This gene has 5 transcripts (splice variants), 199 orthologues, 26 paralogues and is associated with 66 phenotypes. Ubiquitous expression in placenta (RPKM 9.3), bone marrow (RPKM 7.6) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the CMGC family of serine/threonine protein kinases. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Altered expression of this gene has been observed in multiple human cancers. A mutation in this gene resulting in reduced cell proliferation, and impaired cell motility and polarity, and has been identified in patients with primary microcephaly. [provided by RefSeq, Aug 2017]

CDK6 Products (3)

mRNA	Protein	Name
NM_001145306.2	NP_001138778.1	cyclin-dependent kinase 6
NM_001259.8	NP_001250.1	cyclin-dependent kinase 6
XM_047419716.1	XP_047275672.1	cyclin-dependent kinase 6 isoform X1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATP binding	IDA IDA: Inferred from direct assay	9751050	GOA
enables FBXO family protein binding	IPI IPI: Inferred from physical interaction	18495667	GOA
enables cyclin binding	IPI IPI: Inferred from physical interaction	8114739	GOA
enables cyclin-dependent protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	8114739	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	8001816	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in G1/S transition of mitotic cell cycle	IDA IDA: Inferred from direct assay	8114739	GOA
involved in cell dedifferentiation	IMP IMP: Inferred from mutant phenotype	12861051	GOA
involved in gliogenesis	IMP IMP: Inferred from mutant phenotype	12861051	GOA
involved in negative regulation of cell cycle	IDA IDA: Inferred from direct assay	14985467	GOA
involved in negative regulation of cellular senescence	IDA IDA: Inferred from direct assay	17420273	GOA
involved in negative regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	14985467	GOA
involved in negative regulation of monocyte differentiation	IDA IDA: Inferred from direct assay	26542173	GOA
involved in negative regulation of myeloid cell differentiation	IDA IDA: Inferred from direct assay	17431401	GOA
involved in negative regulation of osteoblast differentiation	IDA IDA: Inferred from direct assay	15254224	GOA
involved in positive regulation of cell-matrix adhesion	IDA IDA: Inferred from direct assay	10205165	GOA
involved in positive regulation of fibroblast proliferation	IMP IMP: Inferred from mutant phenotype	17420273	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	8114739	GOA
involved in regulation of erythrocyte differentiation	IMP IMP: Inferred from mutant phenotype	12833137	GOA
involved in regulation of gene expression	IDA IDA: Inferred from direct assay	15254224	GOA
involved in regulation of gene expression	IMP IMP: Inferred from mutant phenotype	17420273	GOA
involved in response to virus	IEP IEP: Inferred from expression pattern	16548883	GOA
involved in type B pancreatic cell development	IDA IDA: Inferred from direct assay	20668294	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in centrosome	IDA IDA: Inferred from direct assay	23918663	GOA
part of cyclin D1-CDK6 complex	IPI IPI: Inferred from physical interaction	15232106	GOA
part of cyclin D3-CDK6 complex	IPI IPI: Inferred from physical interaction	8114739	GOA
part of cyclin-dependent protein kinase holoenzyme complex	IDA IDA: Inferred from direct assay	17420273	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	14985467	GOA
located in nucleus	IDA IDA: Inferred from direct assay	14985467	GOA
located in ruffle	IDA IDA: Inferred from direct assay	10205165	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDK6 Protein Structure

Pkinase

0
100
200
300
326 a.a.

Protein Preferred Names	Protein Names
cyclin-dependent kinase 6	cell division protein kinase 6 serine/threonine-protein kinase PLSTIRE

CDK6 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CDK6	Q00534	CCNI	Homo sapiens	Q14094	Validated Y2H	32296183
Intra	CDK6	Q00534	APOBEC1	Homo sapiens	P41238	Y2H Array	32296183
Intra	CDK6	Q00534	APOBEC1	Homo sapiens	P41238	Y2H Prey Pooling	32296183
Intra	CDK6	Q00534	OTP	Homo sapiens	Q5XKR4	Validated Y2H	32296183
Intra	CDK6	Q00534	OTP	Homo sapiens	Q5XKR4	Y2H Array	32296183
Intra	CDK6	Q00534	OTP	Homo sapiens	Q5XKR4	Y2H Prey Pooling	32296183
Intra	CDK6	Q00534	TRIM15	Homo sapiens	Q9C019	Y2H Prey Pooling	32296183
Intra	CDK6	Q00534	TRIM15	Homo sapiens	Q9C019	Validated Y2H	32296183
Intra	CDK6	Q00534	TRIM15	Homo sapiens	Q9C019	Y2H Array	32296183
Intra	CDK6	Q00534	CDC37	Homo sapiens	Q16543	CoIP	9150368
Intra	CDK6	Q00534	CDC37	Homo sapiens	Q16543	Lumier	25036637
Intra	CDK6	Q00534	CDC37	Homo sapiens	Q16543	Y2H	9150368
Intra	CDK6	Q00534	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	33961781
Intra	CDK6	Q00534	CCND1	Homo sapiens	P24385	Anti Bait CoIP	17517622
Intra	CDK6	Q00534	CCND1	Homo sapiens	P24385	Anti Bait CoIP	24855949
Intra	CDK6	Q00534	CCND1	Homo sapiens	P24385	Anti Tag CoIP	33961781
Intra	CDK6	Q00534	CCND1	Homo sapiens	P24385	Protein Array	15232106
Intra	CDK6	Q00534	CCND3	Homo sapiens	P30281	Validated Y2H	27107012
Intra	CDK6	Q00534	CCND3	Homo sapiens	P30281	Y2H Array	31515488
Intra	CDK6	Q00534	CCND3	Homo sapiens	P30281	Y2H Prey Pooling	25416956
Intra	CDK6	Q00534	CCND3	Homo sapiens	P30281	BFG-2H	27107012
Intra	CDK6	Q00534	CCND3	Homo sapiens	P30281	Validated Y2H	25416956
Intra	CDK6	Q00534	CCND3	Homo sapiens	P30281	TAP	23602568
Intra	CDK6	Q00534	CCND3	Homo sapiens	P30281	Y2H Array	25416956
Intra	CDK6	Q00534	CCND3	Homo sapiens	P30281	MAPPIT	25416956
Intra	CDK6	Q00534	CCND3	Homo sapiens	P30281	Protein Array	15232106
Intra	CDK6	Q00534	CCND3	Homo sapiens	P30281	SLC	27107012
Intra	CDK6	Q00534	CCND3	Homo sapiens	P30281	Anti Bait CoIP	17517622
Intra	CDK6	Q00534	CCND3	Homo sapiens	P30281	Y2H	21516116
Intra	CDK6	Q00534	CDKN2A	Homo sapiens	P42771	Anti Bait CoIP	17909018
Intra	CDK6	Q00534	CDKN2A	Homo sapiens	P42771	Anti Bait CoIP	24855949
Intra	CDK6	Q00534	CDKN2A	Homo sapiens	P42771	TAP	23602568
Intra	CDK6	Q00534	CDKN2A	Homo sapiens	P42771	Anti Tag CoIP	33961781
Intra	CDK6	Q00534	CDKN2A	Homo sapiens	P42771	Anti Tag CoIP	28514442
Intra	CDK6	Q00534	CDKN2A	Homo sapiens	P42771	Pull Down	32707033
Intra	CDK6	Q00534	CDKN2A	Homo sapiens	P42771	Protein Array	15232106
Intra	CDK6	Q00534	CDKN2A	Homo sapiens	P42771	Pull Down	24855949
Intra	CDK6	Q00534	CDKN1A	Homo sapiens	P38936	Anti Tag CoIP	33961781
Intra	CDK6	Q00534	CDKN1A	Homo sapiens	P38936	Anti Tag CoIP	28514442
Intra	CDK6	Q00534	CDKN2B	Homo sapiens	P42772	Anti Tag CoIP	33961781
Intra	CDK6	Q00534	CDKN2B	Homo sapiens	P42772	TAP	23602568
Intra	CDK6	Q00534	CDKN2B	Homo sapiens	P42772	Y2H Array	32296183
Intra	CDK6	Q00534	CDKN2B	Homo sapiens	P42772	Anti Tag CoIP	28514442
Intra	CDK6	Q00534	CDKN2B	Homo sapiens	P42772	Pull Down	32707033
Intra	CDK6	Q00534	CDKN2B	Homo sapiens	P42772	Y2H Prey Pooling	32296183
Intra	CDK6	Q00534	CDKN2C	Homo sapiens	P42773	Validated Y2H	27107012
Intra	CDK6	Q00534	CDKN2C	Homo sapiens	P42773	Y2H Array	31515488
Intra	CDK6	Q00534	CDKN2C	Homo sapiens	P42773	Y2H Array	25502805
Intra	CDK6	Q00534	CDKN2C	Homo sapiens	P42773	Anti Tag CoIP	33961781
Intra	CDK6	Q00534	CDKN2C	Homo sapiens	P42773	Validated Y2H	25416956
Intra	CDK6	Q00534	CDKN2C	Homo sapiens	P42773	TAP	23602568
Intra	CDK6	Q00534	CDKN2C	Homo sapiens	P42773	Y2H Array	25416956
Intra	CDK6	Q00534	CDKN2C	Homo sapiens	P42773	Y2H Array	32296183
Intra	CDK6	Q00534	CDKN2C	Homo sapiens	P42773	Pull Down	32707033
Intra	CDK6	Q00534	CDKN2C	Homo sapiens	P42773	Y2H Prey Pooling	25416956
Intra	CDK6	Q00534	CDKN2C	Homo sapiens	P42773	Pull Down	8840966
Intra	CDK6	Q00534	CDKN2C	Homo sapiens	P42773	Y2H Prey Pooling	32296183
Intra	CDK6	Q00534	CDKN2C	Homo sapiens	P42773	Anti Bait CoIP	18394558
Intra	CDK6	Q00534	CCNH	Homo sapiens	P51946	Y2H Array	32296183
Intra	CDK6	Q00534	CCNH	Homo sapiens	P51946	Y2H Prey Pooling	32296183
Intra	CDK6	Q00534	CDKN2D	Homo sapiens	P55273	Y2H Prey Pooling	32296183
Intra	CDK6	Q00534	CDKN2D	Homo sapiens	P55273	Validated Y2H	27107012
Intra	CDK6	Q00534	CDKN2D	Homo sapiens	P55273	BFG-2H	27107012
Intra	CDK6	Q00534	CDKN2D	Homo sapiens	P55273	Y2H Array	32296183
Intra	CDK6	Q00534	CDKN2D	Homo sapiens	P55273	Anti Tag CoIP	33961781
Intra	CDK6	Q00534	CDKN2D	Homo sapiens	P55273	TAP	23602568
Intra	CDK6	Q00534	CDKN2D	Homo sapiens	P55273	Anti Tag CoIP	28514442
Intra	CDK6	Q00534	CDKN2D	Homo sapiens	P55273	Y2H Array	31515488
Intra	CDK6	Q00534	CDKN2D	Homo sapiens	P55273	Y2H Prey Pooling	25416956
Intra	CDK6	Q00534	CDKN2D	Homo sapiens	P55273	SLC	27107012
Intra	CDK6	Q00534	RUNX1	Homo sapiens	Q01196	Anti Bait CoIP	17431401
Intra	CDK6	Q00534	RUNX1	Homo sapiens	Q01196	Anti Tag CoIP	17431401
Intra	CDK6	Q00534	RUNX1	Homo sapiens	Q01196	PLA	25241761

Cross: Cross-species interaction Intra: Intraspecies interaction

CDK6 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80079	CDK6 Antibody (YA511)	WB, IHC-P, ICC/IF, FC, IF-Tissue	Human
HY-P86594	CDK6 Antibody (YA6286)	WB, IHC-P, ICC/IF, IP, ELISA	Human

Related Diseases

Diseases	Alias
Kaposi Sarcoma	Kaposi'S Sarcoma Kaposi Sarcoma, Susceptibility To Kaposi'S Sarcoma Of Lung Kaposi'S Sarcoma Of Palate Kaposi'S Sarcoma Of Soft Tissue Multiple Idiopathic Pigmented Hemangiosarcoma Multiple Idiopathic Pigmented Hemangiosarcoma, Susceptibility To African Lymphadenopathic Kaposi'S Sarcoma Anal Kaposi'S Sarcoma Cardiac Kaposi'S Sarcoma Central Nervous System Kaposi'S Sarcoma Conjunctival Kaposi'S Sarcoma Corneal Kaposi'S Sarcoma Cutaneous Kaposi'S Sarcoma Esophageal Kaposi'S Sarcoma Gallbladder Kaposi'S Sarcoma Gastric Kaposi'S Sarcoma Intestinal Kaposi'S Sarcoma Kaposi'S Sarcoma Of Anus Kaposi'S Sarcoma Of Central Nervous System Kaposi'S Sarcoma Of Conjunctiva Kaposi'S Sarcoma Of Cornea Kaposi'S Sarcoma Of Esophagus Kaposi'S Sarcoma Of Gastrointestinal Sites Kaposi'S Sarcoma Of Heart Kaposi'S Sarcoma Of Lymph Nodes Kaposi'S Sarcoma Of Penis Kaposi'S Sarcoma Of Skin Kaposi'S Sarcoma Of Soft Tissues Kaposi'S Sarcoma Of The Cns Kaposi'S Sarcoma Of The Gallbladder Kaposi'S Sarcoma Of The Prostate Kaposi'S Sarcoma, Lung Kaposi'S Sarcoma, Skin Kaposi'S Sarcoma-Associated Herpesvirus Lymph Node Kaposi'S Sarcoma Lymphadenopathic Kaposi'S Sarcoma Palate Kaposi'S Sarcoma Penis Kaposi'S Sarcoma Prostate Kaposi'S Sarcoma Pulmonary Kaposi'S Sarcoma Soft Tissue Kaposi'S Sarcoma Hhv8 Human Herpesvirus 8 Kshv Kaposi Sarcoma Herpesvirus Mediterranean Kaposi Sarcoma Non Aids Related Kaposi Sarcoma Sarcoma, Kaposi Sarcoma, Kaposi, Susceptibility To Non-Aids-Related Kaposi Sarcoma Angiolymphoid Hyperplasia Angiofollicular Ganglionic Hyperplasia Multi-Centric Castleman'S Disease
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Leukemia, Myeloid, Acute Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Esophageal Cancer	Esophageal Carcinoma Carcinoma Of Esophagus Esophageal Squamous Cell Carcinoma, Somatic Esophageal Carcinoma, Somatic Esophagus Cancer Gastric Cardia Adenocarcinoma Esophageal Neoplasms Esophageal Cancer, Somatic Cancer Of Esophagus Cancer Of Oesophagus Carcinoma Of Oesophagus Ca Lower Third Oesophagus Ca Middle Third Oesophagus Malignant Neoplasm Of Distal Third Of Esophagus Malignant Neoplasm Of Lower Third Of Oesophagus Malignant Neoplasm Of Middle Third Of Oesophagus Malignant Neoplasm Of Proximal Third Of Esophagus Malignant Neoplasm Of Upper Third Esophagus Malignant Tumor Of Abdominal Esophagus Malignant Tumor Of Distal Third Of Esophagus Malignant Tumor Of Proximal Third Of Esophagus Malignant Tumor Of The Middle Third Of The Esophagus ESCR Aerodigestive Tract Cancer Escc Esophageal Squamous Cell Carcinoma Cancer, Esophageal Malignant Neoplasm Of Esophagus Squamous Cell Carcinoma Of Esophagus Malignant Neoplasm Of Middle Third Of Esophagus
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly
Microcephaly 12, Primary, Autosomal Recessive	MCPH12 Primary Autosomal Recessive Microcephaly 12 Microcephaly, Type 12, Primary, Autosomal Recessive
Ocular Cancer	Eye Carcinoma Eye Neoplasm Eye Cancer Eye Neoplasms Malignant Eye Neoplasm Neoplasm Of Eye Neoplasm Of Eye Proper Ocular Tumor Carcinoma Of Eye Ocular Carcinoma Malignant Tumor Of Eye
Thrombocytopenia	Low Platelet Count Low Platelets Decreased Platelets Platelet Dysfunction Nos
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Adenocarcinoma	Adenocarcinomas Adenoacanthoma Of Unspecified Site Adenocarcinoid Of Unspecified Site Adenocarcinoid Tumour Of Unspecified Site Adenocarcinoma And Carcinoid Combined Of Unspecified Site Adenocarcinoma Nos
Glioblastoma	Glioblastoma Multiforme Gbm Adult Glioblastoma Multiforme Grade Iv Adult Astrocytic Tumor Primary Glioblastoma Multiforme Spongioblastoma Multiforme Adult Glioblastoma Primary Glioblastoma
Rhabdomyosarcoma
Non-Syndromic X-Linked Intellectual Disability	X-Linked Non-Syndromic Intellectual Disability Non-Specific X-Linked Mental Retardation X-Linked Non-Specific Intellectual Disability
Squamous Cell Carcinoma, Head And Neck	Squamous Cell Carcinoma Of The Head And Neck HNSCC Head And Neck Squamous Cell Carcinoma Head And Neck Cancer Squamous Cell Carcinoma Of Lip Squamous Cell Carcinoma, Head And Neck, Somatic Carcinoma Of The Head And Neck Squamous Cell Carcinomas Of Head And Neck Scchn Squamous Cell Carcinoma Of The Hypopharynx Squamous Cell Carcinoma Of The Oropharynx Squamous Cell Carcinoma Of Salivary Glands Squamous Cell Carcinoma Of The Nasal Cavity And Paranasal Sinuses Squamous Cell Carcinoma Of The Nasal Cavity And Sinuses Squamous Cell Carcinoma Of The Oral Cavity Squamous Cell Carcinoma Of The Lip Carcinoma, Squamous Cell Of Head And Neck Lip Squamous Cell Carcinoma Cancer, Head/Neck Carcinoma, Squamous Cell, Head And Neck Salivary Gland Squamous Cell Carcinoma Cancer Of Head And Neck Squamous Cell Carcinoma Of Oropharynx Nos
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Squamous Cell Carcinoma	Epidermoid Carcinoma Squamous Cell Cancer Carcinoma, Squamous Cell Malignant Squamous Cell Tumor Squamous Carcinoma Squamous Cell Epithelioma Squamous Cell Skin Cancer Carcinoma Squamous Cell Neoplasms, Squamous Cell Squamous Cell Carcinoma - Category Malignant Squamous Cell Neoplasm Squamous Cell Carcinoma Of Skin
T-Cell Acute Lymphoblastic Leukemia	T-Cell Leukemia Acute T Cell Leukemia Precursor T Lymphoblastic Leukemia Precursor T-Lymphoblastic Lymphoma/Leukemia T Acute Lymphoblastic Leukemia T-Cell Acute Lymphocytic Leukaemia T-Cell Lymphoblastic Leukemia/Lymphoma Leukemia T-Cell Leukemia, T-Cell Leukemia, Acute, Lymphoblastic, T-Cell Leukemia, T-Cell Acute Lymphoblastic Leukemia, Acute T-Cell Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Precursor T-Cell Lymphoblastic Lymphoma Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma
Leukemia, Acute Lymphoblastic	Acute Lymphoblastic Leukemia ALL Acute Lymphocytic Leukemia Leukemia, Acute Lymphocytic, Susceptibility To, 1 Acute Lymphoblastic Leukaemia Precursor Lymphoblastic Lymphoma/Leukemia Precursor Lymphoid Neoplasm Leukemia, Acute Lymphoblastic, Susceptibility To B-Cell Acute Lymphoblastic Leukemia Leukemia, Acute Lymphocytic 1 Acute Lymphocytic Leukaemia Acute Lymphoblastic Leukemia/Lymphoma All1 Childhood Acute Lymphoblastic Leukemia Leukemia Acute Lymphoblastic 1 Leukemia Acute Lymphoblastic B-Hyperdiploid Leukemia Acute Lymphocytic Leukemia Acute Lymphocytic 1 Leukemia B-Cell Acute Lymphoblastic Leukemia T-Cell Acute Lymphoblastic Leukemia, Acute Lymphoblastic, 3 ALL3 Lymphoblastic Leukemia Acute Leukemia, Acute, Lymphoblastic Precursor Cell Lymphoblastic Leukemia Lymphoma Leukemia, Lymphocytic, Acute, L1 Leukemia, Acute Lymphoblastic, Susceptibility To, 3
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Cancer Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Pancreatic Cancer	Pancreatic Carcinoma Familial Pancreatic Carcinoma Pancreatic Neoplasm Carcinoma Of Pancreas Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Cancer Of The Pancreas Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Primary Microcephaly	True Microcephaly Microcephaly, Primary
Rheumatoid Arthritis	RA Arthritis, Rheumatoid Rheumatoid Arthritis, Susceptibility To Arthritis Or Polyarthritis, Rheumatic Atrophic Arthritis Rheumatism Arthritis Rheumatoid Polyarthritis
Dedifferentiated Liposarcoma	Ddls Liposarcoma Dedifferentiated Liposarcoma, Dedifferentiated
Retinal Cancer	Malignant Neoplasm Of Retina Retinal Neoplasms Malignant Retinal Neoplasm Malignant Tumor Of Retina Neoplasm Of Retina Retinal Tumor Retinal Neoplasm Cancer Of The Retina Malignant Retinal Tumour Malignant Tumour Of Retina Primary Malignant Neoplasm Of Retina
Sarcoma	Connective And Soft Tissue Neoplasm Tumor Of Soft Tissue And Skeleton Sarcomas Sarcoma - Category
Mantle Cell Lymphoma	Lymphoma, Mantle Cell Lcm Mcl Mantle Zone Lymphoma Lymphoma Mantle-Cell Lymphoma, Mantle-Cell Malignant Lymphoma, Lymphocytic, Intermediate Differentiation, Diffuse Malignant Lymphoma - Lymphocytic, Intermediate Differentiation Diffuse Small Cleaved-Cell Lymphoma Diffuse Small Cleaved Cell Malignant Lymphoma Small Cleaved Cell Non-Hodgkin Lymphoma Diffuse Non-Hodgkin Small Cleaved Cell Lymphoma Malignant Lymphomatous Polyposis Malignant Small Cell, Noncleaved, Diffuse Lymphoma Malignant Undifferentiated Cell, Non-Burkitt Lymphoma Cleaved Cell Lymphoma Small Cell Mantle Cell Lymphoma Small Cleaved Cell Malignant Lymphoma
Lymphoma	Lymphoid Cancer Lymphomas Lymphoid Cancers Lymphoid Neoplasm Lymphoma Nos Nhl - [Non-Hodgkin Lymphoma] Non-Hodgkin Lymphoma Non-Hodgkin Lymphoma, Nos Non-Hodgkin Malignant Lymphoma Nos
Sensory System Disease
Breast Cancer	Breast Carcinoma Breast Cancer, Familial Malignant Neoplasm Of Breast Male Breast Cancer Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Lymphoma, Non-Hodgkin, Familial	Non-Hodgkin Lymphoma Lymphoma, Non-Hodgkin NHL Lymphoma, Non-Hodgkin, Somatic Lymphoma, Follicular, Somatic Familial Non-Hodgkin Lymphoma Lymphoma Non-Hodgkins Follicular Lymphoma, Somatic Lymphosarcoma Non-Hodgkins Lymphoma
Endometrial Cancer	Endometrial Carcinoma Endometrial Neoplasm Malignant Neoplasm Of Endometrium Endometrioid Carcinoma Endometrial Neoplasms Carcinoma, Endometrioid Endometrial Cancer, Familial Endometrial Carcinoma, Somatic Endometrial Cancer, Susceptibility To Endometrial Ca Malignant Endometrial Neoplasm Neoplasm Of Endometrium Primary Malignant Neoplasm Of Endometrium Tumor Of Endometrium Carcinoma Of The Endometrium Endometrioid Carcinoma Of Female Reproductive System ENDMC Carcinoma Endometrioid Endometrial Cancers Cancer, Endometrial Uterine Corpus Cancer
Glioma
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Protection Against Lung Cancer, Susceptibility To Adenocarcinoma Of Lung, Somatic Nonsmall Cell Lung Cancer Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Retinoblastoma	RB Trilateral Retinoblastoma RB1 Retinoblastoma, Trilateral Neuroblastoma Of Retina Rb - Retinoblastoma Eye Cancer, Retinoblastoma Retinal Cancer Retinal Tumor Glioma, Retinal Non-Hereditary Retinoblastoma Childhood Cancer Retinoblastoma Malignant Neoplasm Of Retina Retinal Neoplasms
Eye Disease	Eye Diseases Abnormality Of The Eye Toxoplasma Oculopathy
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1
Primary Autosomal Recessive Microcephaly	Autosomal Recessive Primary Microcephaly Mcph True Microcephaly Microcephalia Vera Microcephaly Vera Microcephaly Primary Hereditary Microcephaly, Primary, Autosomal Recessive Primary Microcephaly
Retinal Disease	Retinal Diseases Retinal Disorder Retinal Disorders
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Robinow Syndrome, Autosomal Dominant 3	Autosomal Dominant Robinow Syndrome 3 DRS3 Robinow, Autosomal Dominant Syndrome, Type 3
Neuroblastoma	Nb Neuroblastoma, Susceptibility To Neuroblastomas Central Neuroblastoma
Medulloblastoma	MDB Cpnet Localized Primitive Neuroectodermal Tumor Classic Medulloblastoma Desmoplastic/Nodular Medulloblastoma Medulloblastoma With Extensive Nodularity Desmoplastic Medulloblastoma Medulloblastoma, Somatic Medulloblastoma, Desmoplastic Brain Medulloblastoma Cns Pnet Infratentorial Primitive Neuroectodermal Tumor Mben Medulloblastoma Desmoplastic Neuroectodermal Tumors, Primitive Medulloblastomas Medulloblastoma, With Extensive Nodularity Medulloblastoma Of Unspecified Site Medullomyoblastoma Of Unspecified Site
Prostate Signet Ring Cell Adenocarcinoma	Prostate Signet Ring Cell Carcinoma Signet Ring Cell Carcinoma Of Prostate Acinar Prostate Adenocarcinoma, Signet Ring Variant
Melanoma, Cutaneous Malignant 1	Familial Melanoma Melanoma, Cutaneous Malignant, Susceptibility To, 1 CMM1 Melanoma, Cutaneous Malignant Cmm Melanoma, Malignant Familial Atypical Mole-Malignant Melanoma Syndrome Fammm Melanoma, Familial Mlm Dysplastic Nevus Syndrome, Hereditary Dns B-K Mole Syndrome Melanoma, Cutaneous Malignant, 1 Malignant Melanoma, Cutaneous Melanoma, Cutaneous, Malignant, Susceptibility To, Type 1 Dysplastic Nevus Syndrome Cutaneous Melanoma Familial Atypical Mole Melanoma Syndrome Hereditary Melanoma
Liposarcoma	Lipomatous Cancer

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (15)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-50767	Palbociclib	Inhibitor	99.94%	Unkown
HY-16297A	Abemaciclib	Inhibitor	99.97%	Yes
HY-15777	Ribociclib	Inhibitor	99.94%	Unkown
HY-50767C	Palbociclib hydrochloride	Inhibitor	99.96%	Unkown
HY-50767A	Palbociclib monohydrochloride	Inhibitor	99.98%	Unkown
HY-A0065	Palbociclib isethionate	Inhibitor	99.98%	Unkown
HY-16297	Abemaciclib methanesulfonate	Inhibitor	99.95%	Yes
HY-15777B	Ribociclib succinate	Inhibitor	99.93%	Unkown
HY-15777A	Ribociclib hydrochloride	Inhibitor	99.95%	Unkown
HY-114338	Dalpiciclib	Inhibitor	99.70%	Unkown
HY-101467A	Trilaciclib hydrochloride	Inhibitor	99.69%	Unkown
HY-B0877	Halcinonide	Activator	98.29%	Unkown
HY-15777C	Ribociclib succinate hydrate	Inhibitor	99.94%	Unkown
HY-50767D	Palbociclib orotate	Inhibitor	/	Unkown
HY-50767B	Palbociclib dihydrochloride	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (25)

Cat. No.	Product Name	Effect	Purity	Phase
HY-114338A	Dalpiciclib hydrochloride	Inhibitor	99.41%	Phase 4
HY-122620	Rafutrombopag (tautomerism)	Agonist	98.33%	Phase 4
HY-145589	Rafutrombopag	Agonist	95.29%	Phase 4
HY-112272A	Lerociclib dihydrochloride	Inhibitor	98.51%	Phase 3
HY-112272	Lerociclib	Inhibitor	96.42%	Phase 3
HY-101563	GSK3326595		99.83%	Phase 2
HY-103712A	Samuraciclib hydrochloride	Inhibitor	99.98%	Phase 2
HY-50940	AT7519	Inhibitor	99.69%	Phase 2
HY-137478	KB-0742	Inhibitor	99.63%	Phase 2
HY-137478A	KB-0742 dihydrochloride	Inhibitor	98.77%	Phase 2
HY-103712	Samuraciclib	Inhibitor	99.55%	Phase 2
HY-103712B	Samuraciclib hydrochloride dihydrate	Inhibitor	99.90%	Phase 2
HY-50943	AT7519 Hydrochloride	Inhibitor	99.16%	Phase 2
HY-103712C	Samuraciclib hydrochloride hydrate	Inhibitor	99.88%	Phase 2
HY-50940A	AT7519 TFA	Inhibitor	99.75%	Phase 2
HY-16559A	Riviciclib	Inhibitor	/	Phase 2
HY-10012	AZD-5438	Inhibitor	99.91%	Phase 1
HY-10014	R547	Inhibitor	99.57%	Phase 1
HY-15504	RGB-286638	Inhibitor	99.67%	Phase 1
HY-12624	Narazaciclib	Inhibitor	98.66%	Phase 1
HY-12422	Voruciclib	Inhibitor	99.76%	Phase 1
HY-111361	FN-1501	Inhibitor	98.72%	Phase 1
HY-15504A	RGB-286638 free base	Inhibitor	98.09%	Phase 1
HY-12422A	Voruciclib hydrochloride	Inhibitor	99.26%	Phase 1
HY-182468	OP-3136		99.90%	Phase 1

Pre-clinical Phase

Bioactive Molecules (120)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-103248	Toyocamycin	Inhibitor	99.27%	Unkown
HY-10329	JNJ-7706621	Inhibitor	99.39%	Unkown
HY-114177	Ebvaciclib	Inhibitor	99.98%	Unkown
HY-136250	BSJ-03-204	Inhibitor	99.76%	Unkown
HY-116035	Nimbolide	Inhibitor	99.79%	Unkown
HY-138946	XY028-140	Inhibitor	98.52%	Unkown
HY-N0404	Sinigrin	Inhibitor	99.97%	Unkown
HY-111556	BSJ-03-123	Inhibitor	99.19%	Unkown
HY-136252	BSJ-04-132	Inhibitor	99.07%	Unkown
HY-144117	GFB-12811	Inhibitor	98.04%	Unkown
HY-12445	Asnuciclib	Inhibitor	99.76%	Unkown
HY-N0805	Alisol B 23-acetate	Inhibitor	99.65%	Unkown
HY-128669	Abemaciclib metabolite M2	Inhibitor	99.75%	Unkown
HY-126534A	Abemaciclib metabolite M18 hydrochloride	Inhibitor	98.18%	Unkown
HY-16559	Riviciclib hydrochloride		99.08%	Unkown
HY-148530	YX-2-107	Degrader	98.60%	Unkown
HY-163786	PROTAC CDK4/6 degrader 1	Degrader	98.88%	Unkown
HY-13266A	BS-181 hydrochloride	Inhibitor	99.93%	Unkown
HY-119940	MC180295	Inhibitor	98.07%	Unkown
HY-125835	CP-10	Inhibitor	98.41%	Unkown
HY-129336	Abemaciclib metabolite M20	Inhibitor	95.92%	Unkown
HY-129180	XY028-133	Inhibitor	99.07%	Unkown
HY-151071	TMX-3013	Inhibitor	98.02%	Unkown
HY-15889	AMG 925	Inhibitor	99.02%	Unkown
HY-126534	Abemaciclib metabolite M18	Inhibitor	98.01%	Unkown
HY-50767S	Palbociclib-d8	Inhibitor	99.84%	Unkown
HY-144995	BSJ-02-162	Inhibitor	98.07%	Unkown
HY-148214	CDK2/4/6-IN-2	Inhibitor	98.20%	Unkown
HY-151069	TMX-2039	Inhibitor	99.42%	Unkown
HY-142076	CDK4/6-IN-15	Inhibitor	99.32%	Unkown
HY-164129	CDK4-IN-3	Inhibitor	98.07%	Unkown
HY-152263	HEMTAC CDK4/6 degrader 1	Inhibitor	98.18%	Unkown
HY-153894	SRX3177	Inhibitor	99.33%	Unkown
HY-148062	RSS0680		98.03%	Unkown
HY-114339	CDK4/6-IN-2	Inhibitor	99.67%	Unkown
HY-16942	Damulin B	Inhibitor	≥95.0%	Unkown
HY-126251	CDK9-IN-7	Inhibitor	98.05%	Unkown
HY-136726	CGP-82996	Inhibitor	98.12%	Unkown
HY-129336S	Abemaciclib metabolite M20-d8	Inhibitor	99.26%	Unkown
HY-15241	NVP-LCQ195	Inhibitor	98.88%	Unkown
HY-45661	Inixaciclib	Inhibitor	99.93%	Unkown
HY-148063	DB0614		96.07%	Unkown
HY-155787	SHR5428	Inhibitor	99.80%	Unkown
HY-142696A	CDK6/PIM1-IN-1 hydrochloride	Inhibitor	99.38%	Unkown
HY-115992	CDK4/6-IN-9	Inhibitor	99.46%	Unkown
HY-108420	INK4C-IN-2	Activator	98.10%	Unkown
HY-168996	LA-CB1	Degrader	98.20%	Unkown
HY-146213	CDK4/6-IN-12	Inhibitor	99.76%	Unkown
HY-13266	BS-181	Inhibitor	98.10%	Unkown
HY-185121	PROTAC CDK2/4/6 Degrader-2	Degrader	97.22%	Unkown
HY-168440	Aurora-A ligand 1	Ligand	98.75%	Unkown
HY-123535	P18IN003	Activator	99.49%	Unkown
HY-112243A	Cimpuciclib tosylate	Inhibitor	99.65%	Unkown
HY-112418	CDK4/6-IN-18	Inhibitor	98.9%	Unkown
HY-176713	KWZY-11	Inhibitor	/	Unkown
HY-181490	WWZ-11-098	Degrader	/	Unkown
HY-112346	RGB-286147	Inhibitor	98.60%	Unkown
HY-164906	TMX-2138	Degrader	/	Unkown
HY-142696	CDK6/PIM1-IN-1	Inhibitor	/	Unkown
HY-180277	PROTAC CDK6 Degrader 1	Degrader	/	Unkown
HY-15889A	AMG 925 (HCl)	Inhibitor	/	Unkown
HY-N2423	Sinigrin hydrate	Inhibitor	99.92%	Unkown
HY-112243	Cimpuciclib	Inhibitor	/	Unkown
HY-131063	CDK6/9-IN-1	Inhibitor	/	Unkown
HY-126244	CDK4/6-IN-3	Inhibitor	/	Unkown
HY-162619	CDK9-IN-33	Inhibitor	/	Unkown
HY-179151	CDK4/6-IN-26	Inhibitor	/	Unkown
HY-183571	JD128	Inhibitor	/	Unkown
HY-181483	CDK6-IN-2	Inhibitor	/	Unkown
HY-178452	PROTAC CDK4/6/9 degrader 1	Degrader	/	Unkown
HY-163856	CDK7-IN-30	Inhibitor	/	Unkown
HY-134303	CST651	Degrader	/	Unkown
HY-153088	CDK4/6-IN-16	Inhibitor	/	Unkown
HY-178168	ARUK2010694	Inhibitor	/	Unkown
HY-182071	MG16	Inhibitor	/	Unkown
HY-180279	CDK6 ligand-Linker Conjugate 1	Inhibitor	/	Unkown
HY-179452	KRAS G13D-IN-2	Inhibitor	/	Unkown
HY-176718	VEGFR-2-IN-69	Inhibitor	/	Unkown
HY-143257	CDK4/6-IN-7	Inhibitor	/	Unkown
HY-180262	PROTAC CDK6 Degrader 2	Degrader	/	Unkown
HY-185487	CDK4/6-IN-27	Inhibitor	/	Unkown
HY-148213	CDK2/4/6-IN-1	Inhibitor	/	Unkown
HY-172899	Carbonic anhydrase inhibitor 33	Inhibitor	/	Unkown
HY-143258	CDK4/6-IN-8	Inhibitor	/	Unkown
HY-173237	CDK4/6/BRD4-IN-1	Inhibitor	/	Unkown
HY-137478B	KB-0742 hydrochloride	Inhibitor	/	Unkown
HY-172128	NUAK1-IN-2	Inhibitor	/	Unkown
HY-180912	HS-36	Inhibitor	/	Unkown
HY-147409	Ulecaciclib	Inhibitor	/	Unkown
HY-176365	Palbociclib-C4-Boc	Inhibitor	/	Unkown
HY-170651	CDK4/6/HDAC-IN-1	Inhibitor	/	Unkown
HY-181999	PC8	Inhibitor	/	Unkown
HY-168444	CDK4/6-IN-23	Inhibitor	/	Unkown
HY-178171	ARUK2010489	Inhibitor	96.64%	Unkown
HY-178516	PROTAC CDK4/6/9 degrader 2	Degrader	/	Unkown
HY-164376A	CDK4/6-IN-21 maleate	Inhibitor	/	Unkown
HY-162529	CDK4/6-IN-19	Inhibitor	/	Unkown
HY-180278	CDK6 ligand 1	Inhibitor	/	Unkown
HY-181729	PROTAC BET Degrader-15	Inhibitor	/	Unkown
HY-153336	PRT3645	Inhibitor	/	Unkown
HY-163787	YY173	Inhibitor	/	Unkown
HY-115993	CDK4/6-IN-10	Inhibitor	/	Unkown
HY-179375	LCI133	Inhibitor	/	Unkown
HY-171826	PROTAC CDK2/4/6 Degrader-1	Inhibitor	/	Unkown
HY-181501	CDK2/4/6-IN-3	Inhibitor	/	Unkown
HY-182986	LS-Q2	Inhibitor	/	Unkown
HY-182036	KWZL-7f15	Inhibitor	/	Unkown
HY-164376	CDK4/6-IN-21	Inhibitor	/	Unkown
HY-175013	CDK6/9-IN-2	Inhibitor	/	Unkown
HY-178112	CDK2-IN-47	Inhibitor	/	Unkown
HY-172234	PF-06842874	Inhibitor	/	Unkown
HY-183771	CDK4/6-IN-28	Inhibitor	/	Unkown
HY-151898	CDK4/6-IN-14	Inhibitor	/	Unkown
HY-151878	CDK7-IN-20	Inhibitor	/	Unkown
HY-171656	G721-0282	Inhibitor	99.96%	Unkown
HY-146276	CDK/HDAC-IN-2	Inhibitor	/	Unkown
HY-115942	Anticancer agent 29	Inhibitor	/	Unkown
HY-162530	CDK4/6-IN-20	Inhibitor	/	Unkown
HY-114338B	Dalpiciclib isethionate	Inhibitor	/	Unkown
HY-102088	P18IN011	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CDK6	RGD	RGD:621121
Felis catus	CDK6	VGNC	VGNC:102025
Macaca mulatta	CDK6	VGNC	VGNC:70983
Mus musculus	CDK6	MGD	MGI:1277162
Bos taurus	CDK6	VGNC	VGNC:27133
Canis familiaris	CDK6	VGNC	VGNC:54756
Others	CDK6	NCBI