1. Cell Cycle/DNA Damage
  2. CDK
  3. CDK4/6-IN-3

CDK4/6-IN-3 

Cat. No.: HY-126244
Handling Instructions

CDK4/6-IN-3 is a brain-penetrant CDK4/CDK6 inhibitor with Kis of <0.3 nM and 2.2 nM, respectively. CDK4/6-IN-3 inhibits CDK1 with a Ki of 110 nM. CDK4/6-IN-3 can be used for the treatment of glioblastoma.

For research use only. We do not sell to patients.

CDK4/6-IN-3 Chemical Structure

CDK4/6-IN-3 Chemical Structure

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Description

CDK4/6-IN-3 is a brain-penetrant CDK4/CDK6 inhibitor with Kis of <0.3 nM and 2.2 nM, respectively. CDK4/6-IN-3 inhibits CDK1 with a Ki of 110 nM. CDK4/6-IN-3 can be used for the treatment of glioblastoma[1].

IC50 & Target[1]

CDK4

0.3 nM (Ki)

CDK6

2.2 nM (Ki)

CDK1

110 nM (Ki)

In Vitro

CDK4/6-IN-3 (Compound 24) inhibits MCF7 and BT549 cell lines proliferation with EC50s of 30 nM and 2.1 μM, respectively[1].

Molecular Weight

462.57

Formula

C₂₅H₃₁FN₈

SMILES

FC1=CN=C(NC2=NC=C(N3CC4(CN(CC)C4)C3)C=C2)N=C1C5=C([[email protected]](C)CCCC6)N6N=C5

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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CDK4/6-IN-3
Cat. No.:
HY-126244
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