1. NF-κB
    Cell Cycle/DNA Damage
    Apoptosis
  2. NF-κB
    CDK
    Apoptosis
  3. Nimbolide

Nimbolide 

Cat. No.: HY-116035
Handling Instructions

Nimbolide is a triterpene derived from the leaves and flowers of neem (Azadirachta indica L). Nimbolide induces apoptosis through inactivation of NF-κB. Nimbolide inhibits CDK4/CDK6 kinase activity. Nimbolide suppresses the NF-κB, Wnt, PI3K-Akt, MAPK and JAK-STAT signaling pathways.

For research use only. We do not sell to patients.

Nimbolide Chemical Structure

Nimbolide Chemical Structure

CAS No. : 25990-37-8

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Description

Nimbolide is a triterpene derived from the leaves and flowers of neem (Azadirachta indica L). Nimbolide induces apoptosis through inactivation of NF-κB. Nimbolide inhibits CDK4/CDK6 kinase activity. Nimbolide suppresses the NF-κB, Wnt, PI3K-Akt, MAPK and JAK-STAT signaling pathways[1].

IC50 & Target[1]

NF-κB

 

CDK4

 

CDK6

 

Molecular Weight

466.52

Formula

C₂₇H₃₀O₇

CAS No.

25990-37-8

SMILES

CC1=C2[[email protected]]([H])(O[[email protected]]([H])([[email protected]]3(C4[[email protected]@]5(C(C=C[[email protected]]4(C(O3)=O)C)=O)C)[H])[[email protected]@]2([[email protected]@H]5CC(OC)=O)C)CC1C6=COC=C6

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Nimbolide
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