2. NF-κB
    Cell Cycle/DNA Damage
    Apoptosis
  3. NF-κB
    CDK
    Apoptosis
  4. Nimbolide

Nimbolide 

Cat. No.: HY-116035 Purity: 99.94%
COA Handling Instructions

Nimbolide is a triterpene derived from the leaves and flowers of neem (Azadirachta indica). Nimbolide induces apoptosis through inactivation of NF-κB. Nimbolide inhibits CDK4/CDK6 kinase activity. Nimbolide suppresses the NF-κB, Wnt, PI3K-Akt, MAPK and JAK-STAT signaling pathways.

For research use only. We do not sell to patients.

Nimbolide Chemical Structure

Nimbolide Chemical Structure

CAS No. : 25990-37-8

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5 mg USD 390 In-stock
10 mg USD 630 In-stock
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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Nimbolide

View All NF-κB Isoform Specific Products:

View All Isoforms
NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

View All CDK Isoform Specific Products:

View All Isoforms
CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85

  • Biological Activity

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Description

Nimbolide is a triterpene derived from the leaves and flowers of neem (Azadirachta indica). Nimbolide induces apoptosis through inactivation of NF-κB. Nimbolide inhibits CDK4/CDK6 kinase activity. Nimbolide suppresses the NF-κB, Wnt, PI3K-Akt, MAPK and JAK-STAT signaling pathways[1].

IC50 & Target[1]

NF-κB

 

CDK4

 

CDK6

 

Molecular Weight

466.52

Appearance

Solid

Formula

C27H30O7
CAS No.
SMILES

C[[email protected]]12[[email protected]@]3([H])[[email protected]](OC([[email protected]@]3(C=CC2=O)C)=O)([H])[[email protected]]4([H])[[email protected]]([[email protected]@H]1CC(OC)=O)(C5=C(C)[[email protected]@](C6=COC=C6)([H])C[[email protected]@]5([H])O4)C
Structure Classification
Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (107.18 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1435 mL 10.7177 mL 21.4353 mL
5 mM 0.4287 mL 2.1435 mL 4.2871 mL
10 mM 0.2144 mL 1.0718 mL 2.1435 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1 mg/mL (2.14 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 1 mg/mL (2.14 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.94%

COA (260 KB) HNMR (278 KB) LCMS (258 KB)

Handling Instructions (2659 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Nimbolide25990-37-8NF-κBCDKApoptosisNuclear factor-κBNuclear factor-kappaBCyclin dependent kinaseInhibitorinhibitorinhibit

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