Spectroscopic and biological investigation of nimbolide and 28-deoxonimbolide from Azadirachta indica

  • J Nat Prod. 1989 Nov-Dec;52(6):1246-51. doi: 10.1021/np50066a008.
P G Kigodi  1 ,  G Blaskó ,  Y Thebtaranonth ,  J M Pezzuto ,  G A Cordell
Affiliations
  • 1. Program for Collaborative Research in the Pharmaceutical Sciences, University of Illinois, College of Pharmacy, Chicago 60680.
PMID: 2614419 DOI: 10.1021/np50066a008
Abstract

The reisolation of nimbolide [1] from Azadirachta indica of Tanzanian origin and the isolation and structure elucidation of a new limonoid, 28-deoxonimbolide [2], from the same plant source are reported. For the first time, unambiguous 1H- and 13C-nmr assignments of compounds 1 and 2 are presented, as well as their in vitro cytotoxic activity against human tumor cell lines.