Azadirachta indica A. Juss.

Nimbolide is a triterpene compound that can be isolated from neem (Azadirachta indica), possesses anticancer and antiproliferative activity. Nimbolide induces tumor cell apoptosis by inhibiting NF-κB and CDK4/CDK6 kinase. Nimbolide suppresses the Wnt, PI3K-Akt, MAPK and JAK-STAT signaling pathways.

Azadirachtin is an oral active triterpenoid compound with anticancer, antimalarial, anti-inflammatory, and insecticidal activities. Azadirachtin induces cell apoptosis through the mitochondrial pathway (by inhibiting Bcl-2/Bax ratio or activating Apaf-1 and caspase-3) or through death receptors (by inhibiting TNFR activation). Additionally, Azadirachtin exerts its anti-inflammatory effects by inhibiting NF-кB signaling pathway activation, and it exhibits insecticidal activity by inducing apoptosis in insect cells.

Azadirachtin (Standard) is the analytical standard of Azadirachtin. This product is intended for research and analytical applications. Azadirachtin, one of the most promising botanical insecticides, is widely used for pest control. Azadirachtin induces apoptosis in insect cell lines, including Sf9, SL-1 and BTI-Tn-5B1-4.

14,15-Epoxyazadiradione is a triterpenoid found in Azadirachta indica. Azadirachta indica shows anti-infection, anti-inflammatory and anticancer activities. Azadirachtin H can be used for the researches of cancer, infection and inflammation.

Azadirachtin D is an insect growth regulator targeting ecdysone receptor (EcR) in insects. Azadirachtin D blocks the 20-hydroxyecdysone signaling pathway, leading to developmental arrest or death in insects. Azadirachtin D is promising for research of agricultural pests.

Azadirachtin H is a triterpenoid found in Azadirachta indica. Azadirachta indica shows anti-infection, anti-inflammatory and anticancer activities. Azadirachtin H can be used for the researches of cancer, infection and inflammation.

Azadirachtin I is an insecticide targeting insect growth and development-related pathways (e.g., ecdysone signaling pathway, chitin synthesis pathway). Azadirachtin I inhibits chitin synthesis and disrupting intestinal function by interfering with the growth and development processes of insect larvae such as molting and pupation, increasing insect mortality and reducing adult fecundity. Azadirachtin I is promising for research of agricultural pests, such as Lepidoptera, Coleoptera.

Nimbiol exhibits binding energy for FtsZ and shows potential anti-FtsZ effect.

28-Deoxonimbolide is a Nimbin (HY-N3187) type limonoid, that can be isolated from Azadirachta indica seed extracts. 28-Deoxonimbolide shows anticancer activity. 28-Deoxonimbolide induces apoptotic cell death in HL60 cells via both the mitochondrial- and the death receptor-mediated pathways.

Deacetylnimbin is a limonoid isolated from Azadirachta indica. Deacetylnimbin can be used as a plant metabolite, a food repellent and as a growth regulator for insects such as S. litura, P. ricini and O. fscovittata.

2',3'-Dehydrosalannol is a potent antibacterial agent. 2',3'-Dehydrosalannol shows antibacterial activity against K. pneumonia ATCC 13883, P. aeruginosa ATCC 27853, S. aureus ATCC 25922, E. coli ATCC 11775, and E. faecalis ATCC 10541, with MIC values of 0.78, 1.56, 1.56, 6.25, and 25 μg/mL, respectively.

6-Acetylnimbandiol (6-O-Acetylnimbandiol) is a non-cytotoxic tyrosinase inhibitor (IC₅₀=69.85 μM) that effectively inhibits melanin production and MITF expression. 6-Acetylnimbandiol can be used in melanoma research.

Nimbolide (Standard) is the analytical standard of Nimbolide. This product is intended for research and analytical applications. Nimbolide is a triterpene compound that can be isolated from neem (Azadirachta indica), possesses anticancer and antiproliferative activity. Nimbolide induces tumor cell apoptosis by inhibiting NF-κB and CDK4/CDK6 kinase. Nimbolide suppresses the Wnt, PI3K-Akt, MAPK and JAK-STAT signaling pathways.

Alloxan is a natural product.

6-Deacetylnimbinene is a triterpenoid product that can be isolated from Azadirachta indica A. Juss.

Methyl 14-methylpentadecanoate is an ester product.

Nimbocinone, isolated from Azadirachta indica, exhibits antidiabetogenic activity.