2. Metabolic Enzyme/Protease
  3. Tyrosinase
  4. 6-Acetylnimbandiol

6-Acetylnimbandiol  (Synonyms: 6-O-Acetylnimbandiol)

Cat. No.: HY-N10437
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6-Acetylnimbandiol (6-O-Acetylnimbandiol) is a non-cytotoxic tyrosinase inhibitor (IC50=69.85 μM) that effectively inhibits melanin production and MITF expression. 6-Acetylnimbandiol can be used in melanoma research.

For research use only. We do not sell to patients.

6-Acetylnimbandiol Chemical Structure

6-Acetylnimbandiol Chemical Structure

CAS No. : 1281766-66-2

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6-Acetylnimbandiol Related Antibodies

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Description

6-Acetylnimbandiol (6-O-Acetylnimbandiol) is a non-cytotoxic tyrosinase inhibitor (IC50=69.85 μM) that effectively inhibits melanin production and MITF expression. 6-Acetylnimbandiol can be used in melanoma research[1].

IC50 & Target[1]

Tyrosinas

69.85 μM (IC50)

In Vitro

6-Acetylnimbandiol (10, 30, 100 µM; 48 h) shows antimelanogenic activity in B16 melanoma cells[1].
6-Acetylnimbandiol (50, 100 µM; 48 h) exerts melanogenesis inhibition by inhibiting expression of MITF, tyrosinase, TRP-1, and TRP-2 in B16 melanoma cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

6-Acetylnimbandiol Related Antibodies

Cell Viability Assay[1]

Cell Line: B16 melanoma cells
Concentration: 10, 30, 100 µM
Incubation Time: 48 h
Result: Exhibited potent melanogenesis-inhibitory effect with 22.9% melanin content at 100 μM.

Western Blot Analysis[1]

Cell Line: B16 melanoma cells
Concentration: 50, 100 µM
Incubation Time: 48 h
Result: Inhibited tyrosinase with an IC50 value of 69.85 μM.
Molecular Weight

498.56

Formula

C28H34O8
CAS No.
SMILES

C[C@]12[C@@H]([C@@]3([C@@]([C@](O)(C=CC3=O)C)([H])[C@H]([C@@]1([H])O[C@@]4([H])C2=C([C@@](C5=COC=C5)([H])C4)C)OC(C)=O)C)CC(OC)=O
Structure Classification
Initial Source
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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6-Acetylnimbandiol Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

6-Acetylnimbandiol1281766-66-26-O-AcetylnimbandiolTyrosinaseB16 melanomamelanomaMITFTRP-1TRP-2Inhibitorinhibitorinhibit

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