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Cat. No.: HY-N10437

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6-Acetylnimbandiol

(Synonyms: 6-O-Acetylnimbandiol)

6-Acetylnimbandiol (6-O-Acetylnimbandiol) is a non-cytotoxic tyrosinase inhibitor (IC₅₀=69.85 μM) that effectively inhibits melanin production and MITF expression. 6-Acetylnimbandiol can be used in melanoma research.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 1281766-66-2
Formule: C₂₈H₃₄O₈
Masse moléculaire:498.56

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (279 KB)

6-Acetylnimbandiol Chemical Structure

CAS No.: 1281766-66-2

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target^[1]

Tyrosinas

69.85 μM (IC₅₀)

In Vitro

6-Acetylnimbandiol (10, 30, 100 µM; 48 h) shows antimelanogenic activity in B16 melanoma cells^[1].
6-Acetylnimbandiol (50, 100 µM; 48 h) exerts melanogenesis inhibition by inhibiting expression of MITF, tyrosinase, TRP-1, and TRP-2 in B16 melanoma cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

B16 melanoma cells
Concentration:

10, 30, 100 µM
Incubation Time:

48 h
Result:

Exhibited potent melanogenesis-inhibitory effect with 22.9% melanin content at 100 μM.

Western Blot Analysis^[1]

Cell Line:

B16 melanoma cells
Concentration:

50, 100 µM
Incubation Time:

48 h
Result:

Inhibited tyrosinase with an IC₅₀ value of 69.85 μM.

Chemical Information

CAS No. 1281766-66-2
Masse moléculaire 498.56
Formule C₂₈H₃₄O₈
SMILES

C[C@]12[C@@H]([C@@]3([C@@]([C@](O)(C=CC3=O)C)([H])[C@H]([C@@]1([H])O[C@@]4([H])C2=C([C@@](C5=COC=C5)([H])C4)C)OC(C)=O)C)CC(OC)=O
Synonyms

6-O-Acetylnimbandiol
Structure Classification
- Terpenoids
- Diterpenoids
Initial Source
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (279 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Su S, et al. Melanogenesis-inhibitory activities of limonoids and tricyclic diterpenoids from Azadirachta indica. Bioorg Chem. 2020 Jul;100:103941. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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