country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-N10437

Copy Link Print Information

6-Acetylnimbandiol

(Synonyms: 6-O-Acetylnimbandiol)

6-Acetylnimbandiol (6-O-Acetylnimbandiol) is a non-cytotoxic tyrosinase inhibitor (IC₅₀=69.85 μM) that effectively inhibits melanin production and MITF expression. 6-Acetylnimbandiol can be used in melanoma research.

For research use only. We do not sell to patients.

CAS No.: 1281766-66-2
Formula: C₂₈H₃₄O₈
Molecular Weight:498.56

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (279 KB)

6-Acetylnimbandiol Chemical Structure

CAS No.: 1281766-66-2

Size

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

Tyrosinas

69.85 μM (IC₅₀)

In Vitro

6-Acetylnimbandiol (10, 30, 100 µM; 48 h) shows antimelanogenic activity in B16 melanoma cells^[1].
6-Acetylnimbandiol (50, 100 µM; 48 h) exerts melanogenesis inhibition by inhibiting expression of MITF, tyrosinase, TRP-1, and TRP-2 in B16 melanoma cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

B16 melanoma cells
Concentration:

10, 30, 100 µM
Incubation Time:

48 h
Result:

Exhibited potent melanogenesis-inhibitory effect with 22.9% melanin content at 100 μM.

Western Blot Analysis^[1]

Cell Line:

B16 melanoma cells
Concentration:

50, 100 µM
Incubation Time:

48 h
Result:

Inhibited tyrosinase with an IC₅₀ value of 69.85 μM.

Chemical Information

CAS No. 1281766-66-2
Molecular Weight 498.56
Formula C₂₈H₃₄O₈
SMILES

C[C@]12[C@@H]([C@@]3([C@@]([C@](O)(C=CC3=O)C)([H])[C@H]([C@@]1([H])O[C@@]4([H])C2=C([C@@](C5=COC=C5)([H])C4)C)OC(C)=O)C)CC(OC)=O
Synonyms

6-O-Acetylnimbandiol
Structure Classification
- Terpenoids
- Diterpenoids
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (279 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Su S, et al. Melanogenesis-inhibitory activities of limonoids and tricyclic diterpenoids from Azadirachta indica. Bioorg Chem. 2020 Jul;100:103941. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote