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  4. Meliaceae

Meliaceae

 

Meliaceae (170):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-Y1787
    Dimethyl malonate 108-59-8 99.92%
    Dimethyl malonate is a competitive inhibitor of succinate dehydrogenase (SDH). Dimethyl malonate is able to cross the blood-brain barrier and hydrolyse to malonate. Dimethyl malonate reduces neuronal apoptosis.
    Dimethyl malonate
  • HY-19356
    Rocaglamide 84573-16-0 99.34%
    Rocaglamide (Roc-A) is isolated from the genus Aglaia and can be used for coughs, injuries, asthma and inflammatory skin diseases. Rocaglamide is a potent inhibitor of NF-κB activation in T-cells. Rocaglamide is a potent and selective heat shock factor 1 (HSF1) activation inhibitor with an IC50 of ~50 nM. Rocaglamide inhibits the function of the translation initiation factor eIF4A. Rocaglamide also has anticancer properties in leukemia.
    Rocaglamide
  • HY-N0263
    Toosendanin 58812-37-6 98.77%
    Toosendanin, a triterpenoid extracted from the bark of fruit of Melia toosendan Sieb. et Zucc., possesses analgesic, insecticidal and anti-inflammatory activities.
    Toosendanin
  • HY-116035
    Nimbolide 25990-37-8 99.79%
    Nimbolide is a triterpene compound that can be isolated from neem (Azadirachta indica), possesses anticancer and antiproliferative activity. Nimbolide induces tumor cell apoptosis by inhibiting NF-κB and CDK4/CDK6 kinase. Nimbolide suppresses the Wnt, PI3K-Akt, MAPK and JAK-STAT signaling pathways.
    Nimbolide
  • HY-126741
    Azadirachtin 11141-17-6 99.06%
    Azadirachtin is an oral active triterpenoid compound with anticancer, antimalarial, anti-inflammatory, and insecticidal activities. Azadirachtin induces cell apoptosis through the mitochondrial pathway (by inhibiting Bcl-2/Bax ratio or activating Apaf-1 and caspase-3) or through death receptors (by inhibiting TNFR activation). Additionally, Azadirachtin exerts its anti-inflammatory effects by inhibiting NF-кB signaling pathway activation, and it exhibits insecticidal activity by inducing apoptosis in insect cells.
    Azadirachtin
  • HY-N19786
    Corosin 53527-49-4
    Corosin (Vismiaefolic acid) is a triterpenoid compound that can be isolated from Chisocheton paniculatus.
    Corosin
  • HY-N18195
    Trichilin B 77210-33-4
    Trichilin B is a limonoid compound found in the twigs and leaves of Trichilia connaroides. Trichilin B exhibits no in vitro cytotoxic activity against tumor cell lines.
    Trichilin B
  • HY-N18283
    1α-Benzoyloxy-3α-acetoxyl-7α-hydroxy-12α-ethoxynimbolinin 1239945-88-0
    1α-Benzoyloxy-3α-acetoxyl-7α-hydroxy-12α-ethoxynimbolinin
  • HY-19355
    Rocagloic acid 190385-15-0
    Rocagloic acid is a racaglamide derivative isolated from the fruits of Aglaia elliptifolia with potent cytotoxicity.
    Rocagloic acid
  • HY-N7694
    Isotoosendanin 97871-44-8 99.51%
    Isotoosendanin is an orally active TGFβR1 inhibitor and abrogating its kinase activity (IC50 = 6732 nM). Isotoosendanin inhibits the JAK/STAT3 signaling pathway by directly targeting SHP-2, enhancing its stability, and reducing its ubiquitination. Isotoosendanin inhibits TGF-β-induced reduces the migration, invasion, and metastasis in triple-negative breast cancer (TNBC) cells. Isotoosendanin exhibits anti-tumor efficacy in TNBC xenograft models and A549 xenograft tumors. Isotoosendanin exhibits significant anti-inflammatory effects in acetic acid-induced vascular permeability and λ-carrageenan-induced hind paw edema tests. Isotoosendanin can be used for the study of non-small cell lung cancer (NSCLC), TNBC and inflammation.
    Isotoosendanin
  • HY-15359
    Episilvestrol 697235-39-5 99.86%
    Episilvestrol is a derivative of silvestrol, isolated from the fruits and twigs of Aglaia perviridis, and is a specific eIF4A-targeting translation inhibitor, with antitumor activity.
    Episilvestrol
  • HY-N11958
    5-Hydroxy-3,6,7,4'-tetramethoxyflavone 14787-34-9 99.76%
    5-Hydroxy-3,6,7,4'-tetramethoxyflavone is a natural compound isolated from Aglaia edulis.
    5-Hydroxy-3,6,7,4'-tetramethoxyflavone
  • HY-Y1787R
    Dimethyl malonate (Standard) 108-59-8
    Dimethyl malonate is a competitive inhibitor of succinate dehydrogenase (SDH). Dimethyl malonate is able to cross the blood-brain barrier and hydrolyse to malonate. Dimethyl malonate reduces neuronal apoptosis.
    Dimethyl malonate (Standard)
  • HY-126741R
    Azadirachtin (Standard) 11141-17-6
    Azadirachtin (Standard) is the analytical standard of Azadirachtin. This product is intended for research and analytical applications. Azadirachtin, one of the most promising botanical insecticides, is widely used for pest control. Azadirachtin induces apoptosis in insect cell lines, including Sf9, SL-1 and BTI-Tn-5B1-4.
    Azadirachtin (Standard)
  • HY-N1281
    Sendanolactone 64929-59-5
    Sendanolactone is a new tetracyclic triterpenoid from the bark of M. azedarach L. var. japonica Makino.
    Sendanolactone
  • HY-N1142
    Torachrysone 22649-04-3
    Torachrysone (Nakahalene; Trachrysone), a naphthalene, can be isolated from Cassia tora L.
    Torachrysone
  • HY-N1342
    Rocaglaol 147059-46-9
    Rocaglaol induces apoptosis and cell cycle arrest in LNCaP cells.
    Rocaglaol
  • HY-W001251
    3,5-Dimethoxybenzoic acid 1132-21-4 99.66%
    3,5-Dimethoxybenzoic acid is an aromatic organic acid and antifungal agent. 3,5-Dimethoxybenzoic acid can also be used as an intermediate for anticancer agents. 3,5-Dimethoxybenzoic acid can be isolated from the leaves of Melia azedarach. 3,5-Dimethoxybenzoic acid exhibits antifungal activity against A. rabiei with an MIC of 0.125 mg/mL. 3,5-Dimethoxybenzoic acid has anti-wrinkle, anti-inflammatory, antioxidant, and skin regeneration effects.
    3,5-Dimethoxybenzoic acid
  • HY-N5104
    Clemaphenol A 362606-60-8 99.77%
    Clemaphenol A is a chemical constituent of the flower of Fritillaria pallidiflora.
    Clemaphenol A
  • HY-138545
    4-Hydroxy-6-methylcoumarin 13252-83-0
    4-Hydroxy-6-methylcoumarin is a Coumarin product.
    4-Hydroxy-6-methylcoumarin