(±)-Pinoresinol
(±)-Pinoresinol is a potent antifungal agent. (±)-Pinoresinol shows antifungal activity.
For research use only. We do not sell to patients.
- CAS No.: 4263-88-1
- Formula: C20H22O6
- Molecular Weight:358.39
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| BV-2 | IC50 |
31.1 μM
Compound: 9; Pinoresinol
|
Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay
Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay
|
[PMID: 26774654] |
| BV-2 | IC50 |
76.19 μM
Compound: 20
|
Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced NO production after 24 hrs in presence of LPS by Griess reaction based assay
Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced NO production after 24 hrs in presence of LPS by Griess reaction based assay
|
[PMID: 28911817] |
| HepG2 | IC50 |
51 nM
Compound: 47
|
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
|
[PMID: 37847948] |
| Neutrophil | IC50 |
>10 μg/mL
Compound: 20
|
Anti-inflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced elastase release pre-incubated for 5 mins before fMLP/CB stimulation using MeO-Suc-Ala-Ala-Pro-Val-pnitroanilide as substrate
Anti-inflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced elastase release pre-incubated for 5 mins before fMLP/CB stimulation using MeO-Suc-Ala-Ala-Pro-Val-pnitroanilide as substrate
|
[PMID: 28218000] |
| Neutrophil | IC50 |
1.3 μg/mL
Compound: 20
|
Anti-inflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced superoxide anion generation by measuring superoxide dismutase SOD-inhibitable ferricytochrome c reduction incubated for 5 mins before fMLP/CB stimulation for 3 mins
Anti-inflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced superoxide anion generation by measuring superoxide dismutase SOD-inhibitable ferricytochrome c reduction incubated for 5 mins before fMLP/CB stimulation for 3 mins
|
[PMID: 28218000] |
| PANC-1 | IC50 |
37.5 μM
Compound: 7
|
Cytotoxicity against human PANC1 cells after 72 hrs by WST8 assay
Cytotoxicity against human PANC1 cells after 72 hrs by WST8 assay
|
[PMID: 28495081] |
(±)-Pinoresinol shows antifungal activity with a MIC value of 1.0 mg/mL for Fusarium verticillioides[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 4263-88-1
-
Molecular Weight 358.39
-
Formula C20H22O6
-
SMILES
COC1=C(O)C=CC([C@@H]2[C@]3([H])[C@@](CO2)([H])[C@@H](C4=CC(OC)=C(C=C4)O)OC3)=C1
-
Structure Classification
-
Initial Source
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(±)-Pinoresinol Related Classifications
HY-N0957 Related Classifications
Powered by Bioz