(±)-Pinoresinol

Cat. No.: HY-N0957: Data Sheet Handling Instructions
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(±)-Pinoresinol is a potent antifungal agent. (±)-Pinoresinol shows antifungal activity.

For research use only. We do not sell to patients.

(±)-Pinoresinol Chemical Structure

CAS No. : 4263-88-1

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Other Forms of (±)-Pinoresinol:

Pinoresinol In-stock

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Biological Activity
Purity & Documentation
References
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Description

(±)-Pinoresinol is a potent antifungal agent. (±)-Pinoresinol shows antifungal activity^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
BV-2	IC₅₀	31.1 μM Compound: 9; Pinoresinol	Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay	[PMID: 26774654]
BV-2	IC₅₀	76.19 μM Compound: 20	Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced NO production after 24 hrs in presence of LPS by Griess reaction based assay Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced NO production after 24 hrs in presence of LPS by Griess reaction based assay	[PMID: 28911817]
HepG2	IC₅₀	51 nM Compound: 47	Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 37847948]
Neutrophil	IC₅₀	1.3 μg/mL Compound: 20	Anti-inflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced superoxide anion generation by measuring superoxide dismutase SOD-inhibitable ferricytochrome c reduction incubated for 5 mins before fMLP/CB stimulation for 3 mins by spectrophotometry Anti-inflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced superoxide anion generation by measuring superoxide dismutase SOD-inhibitable ferricytochrome c reduction incubated for 5 mins before fMLP/CB stimulation for 3 mins by spectrophotometry	[PMID: 28218000]
Neutrophil	IC₅₀	> 10 μg/mL Compound: 20	Anti-inflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced elastase release pre-incubated for 5 mins before fMLP/CB stimulation using MeO-Suc-Ala-Ala-Pro-Val-pnitroanilide as substrate Anti-inflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced elastase release pre-incubated for 5 mins before fMLP/CB stimulation using MeO-Suc-Ala-Ala-Pro-Val-pnitroanilide as substrate	[PMID: 28218000]
PANC-1	IC₅₀	37.5 μM Compound: 7	Cytotoxicity against human PANC1 cells after 72 hrs by WST8 assay Cytotoxicity against human PANC1 cells after 72 hrs by WST8 assay	[PMID: 28495081]

In Vitro

(±)-Pinoresinol shows antifungal activity with a MIC value of 1.0 mg/mL for Fusarium verticillioides^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

358.39

Formula

C₂₀H₂₂O₆

CAS No.

4263-88-1

SMILES

COC1=C(O)C=CC([C@@H]2[C@]3([H])[C@@](CO2)([H])[C@@H](C4=CC(OC)=C(C=C4)O)OC3)=C1

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Kim SY, et al. Effect of Pinoresinol and Vanillic Acid Isolated from Catalpa bignonioides on Mouse Myoblast Proliferation via the Akt/mTOR Signaling Pathway. Molecules. 2022 Aug 24;27(17):5397. [Content Brief]

(±)-Pinoresinol Related Classifications

Infection

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(±)-Pinoresinol4263-88-1FungalInhibitorinhibitorinhibit

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