Melia toosendan Sieb. et Zucc.

Toosendanin, a triterpenoid extracted from the bark of fruit of Melia toosendan Sieb. et Zucc., possesses analgesic, insecticidal and anti-inflammatory activities.

Isotoosendanin is an orally active TGFβR1 inhibitor and abrogating its kinase activity (IC₅₀ = 6732 nM). Isotoosendanin inhibits the JAK/STAT3 signaling pathway by directly targeting SHP-2, enhancing its stability, and reducing its ubiquitination. Isotoosendanin inhibits TGF-β-induced reduces the migration, invasion, and metastasis in triple-negative breast cancer (TNBC) cells. Isotoosendanin exhibits anti-tumor efficacy in TNBC xenograft models and A549 xenograft tumors. Isotoosendanin exhibits significant anti-inflammatory effects in acetic acid-induced vascular permeability and λ-carrageenan-induced hind paw edema tests. Isotoosendanin can be used for the study of non-small cell lung cancer (NSCLC), TNBC and inflammation.

Torachrysone (Nakahalene; Trachrysone), a naphthalene, can be isolated from Cassia tora L.

Neoazedarachin B is an insect antifeedant present in the root bark of Melia toosendan. Neoazedarachin B reduces the feeding behavior of third-instar larvae of Spodoptera littoralis.

Nimbolinin C is an insect antifeedant present in the unripe fruits of Melia toosendan. Nimbolinin C exhibits weak activity against the feeding behavior of third-instar larvae of Spodoptera exigua at a concentration of 1000 ppm.

Toosendanin (Standard) is the analytical standard of Toosendanin. This product is intended for research and analytical applications. Toosendanin, a triterpenoid extracted from the bark of fruit of Melia toosendan Sieb. et Zucc., possesses analgesic, insecticidal and anti-inflammatory activities.