97871-44-8
Chemical Structure
Isotoosendanin
- CAS No.: 97871-44-8
- Formula:C30H38O11
- Molecular Weight:574.62
IUPAC Name: (1S,3R,4R,5R,7R,8S,9S,10S,12R,13S,14S,17S)-17-(furan-3-yl)-1,7,20-trihydroxy-4,8,13-trimethyl-11,15-dioxohexadecahydro-4,10-(methanooxymethano)cyclopenta[a]phenanthrene-3,12-diyl diacetate
InChIKey: GEHGAWHOBGXBGC-MFIPDTIPSA-N
SMILES: O[C@@H](C[C@H]1OC(C)=O)[C@]([C@](C[C@H]2O)([H])[C@@]31C)(COC3O)[C@](C([C@@H]4OC(C)=O)=O)([H])[C@@]2([C@@](C5=O)([H])[C@@]4([C@@](C6=COC=C6)([H])C5)C)C
Biological Activity: Isotoosendanin is an orally active TGFβR1 inhibitor and abrogating its kinase activity (IC50 = 6732 nM). Isotoosendanin inhibits the JAK/STAT3 signaling pathway by directly targeting SHP-2, enhancing its stability, and reducing its ubiquitination. Isotoosendanin inhibits TGF-β-induced reduces the migration, invasion, and metastasis in triple-negative breast cancer (TNBC) cells. Isotoosendanin exhibits anti-tumor efficacy in TNBC xenograft models and A549 xenograft tumors. Isotoosendanin exhibits significant anti-inflammatory effects in acetic acid-induced vascular permeability and λ-carrageenan-induced hind paw edema tests. Isotoosendanin can be used for the study of non-small cell lung cancer (NSCLC), TNBC and inflammation[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Isotoosendanin | 99.51% | Isotoosendanin is an orally active TGFβR1 inhibitor and abrogating its kinase activity (IC50 = 6732 nM). Isotoosendanin inhibits the JAK/STAT3 signaling pathway by directly targeting SHP-2, enhancing its stability, and reducing its ubiquitination. Isotoosendanin inhibits TGF-β-induced reduces the migration, invasion, and metastasis in triple-negative breast cancer (TNBC) cells. Isotoosendanin exhibits anti-tumor efficacy in TNBC xenograft models and A549 xenograft tumors. Isotoosendanin exhibits significant anti-inflammatory effects in acetic acid-induced vascular permeability and λ-carrageenan-induced hind paw edema tests. Isotoosendanin can be used for the study of non-small cell lung cancer (NSCLC), TNBC and inflammation. | ||||||||||||||||||||
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References
- [1]. Zhang J, et al. Isotoosendanin exerts inhibition on triple-negative breast cancer through abrogating TGF-β-induced epithelial-mesenchymal transition via directly targeting TGFβR1. Acta Pharm Sin B. 2023 Jul;13(7):2990-3007. [Content Brief]
- [2]. Shu C, et al. Isotoosendanin exerts anti-tumor effects in NSCLC by enhancing the stability of SHP-2 and inhibiting the JAK/STAT3 pathway. Phytomedicine. 2024 Sep;132:155832. [Content Brief]
- [3]. Xie F, et al. Anti-inflammatory and analgesic activities of ethanolic extract and two limonoids from Melia toosendan fruit. J Ethnopharmacol. 2008 May 22;117(3):463-6. [Content Brief]
