1. Terpenoids and Glycosides
  2. Toosendanin

Toosendanin 

Cat. No.: HY-N0263
Handling Instructions

Toosendanin, a triterpenoid extracted from the bark of fruit of Melia toosendan Sieb et Zucc, possesses analgesic, insecticidal and anti-inflammatory activities.

For research use only. We do not sell to patients.

Toosendanin Chemical Structure

Toosendanin Chemical Structure

CAS No. : 58812-37-6

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Top Publications Citing Use of Products

Publications Citing Use of MCE Toosendanin

    Toosendanin purchased from MCE. Usage Cited in: Int Immunopharmacol. 2019 Sep 11;76:105909. 

    TSN promotes the cell tight junction in DSS-induced colitis. The expression of ZO-1 and occludin in colonic tissue are texted by western blot and normalized to GAPDH.
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    Description

    Toosendanin, a triterpenoid extracted from the bark of fruit of Melia toosendan Sieb et Zucc, possesses analgesic, insecticidal and anti-inflammatory activities[1].

    In Vivo

    Toosendanin (0.5 and 1 mg/kg, Intraperitoneal injection daily for 7 days) alleviates DSS-induced experimental colitis by inhibiting M1 macrophage polarization and regulating NLRP3 inflammasome and Nrf2/HO-1 signaling, and may provide a novel Chinese patent medicine for the treatment of murine colitis[1].

    Animal Model: Forty-eight male C57BL/6 mice weighing 20-22 g[1].
    Dosage: 0.5 and 1 mg/kg.
    Administration: Intraperitoneal injection daily for 7 days.
    Result: Protected against DSS-induced colitis in mice.
    Inhibited the expression of proinflammatory cytokines in DSS-induced UC and improved oxidative stress.
    Molecular Weight

    574.62

    Formula

    C₃₀H₃₈O₁₁

    CAS No.

    58812-37-6

    SMILES
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    Room temperature in continental US; may vary elsewhere

    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.

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    Toosendanin
    Cat. No.:
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