1. Terpenoids and Glycosides
  2. Toosendanin

Toosendanin 

Cat. No.: HY-N0263 Purity: >98.0%
Handling Instructions

Toosendanin, a triterpenoid extracted from the bark of fruit of Melia toosendan Sieb et Zucc, possesses analgesic, insecticidal and anti-inflammatory activities.

For research use only. We do not sell to patients.

Toosendanin Chemical Structure

Toosendanin Chemical Structure

CAS No. : 58812-37-6

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 76 In-stock
Estimated Time of Arrival: December 31
5 mg USD 60 In-stock
Estimated Time of Arrival: December 31
10 mg USD 100 In-stock
Estimated Time of Arrival: December 31
20 mg USD 180 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 2 publication(s) in Google Scholar

Top Publications Citing Use of Products

Publications Citing Use of MCE Toosendanin

    Toosendanin purchased from MCE. Usage Cited in: Int Immunopharmacol. 2019 Sep 11;76:105909. 

    TSN promotes the cell tight junction in DSS-induced colitis. The expression of ZO-1 and occludin in colonic tissue are texted by western blot and normalized to GAPDH.
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    Description

    Toosendanin, a triterpenoid extracted from the bark of fruit of Melia toosendan Sieb et Zucc, possesses analgesic, insecticidal and anti-inflammatory activities[1].

    In Vivo

    Toosendanin (0.5 and 1 mg/kg, Intraperitoneal injection daily for 7 days) alleviates DSS-induced experimental colitis by inhibiting M1 macrophage polarization and regulating NLRP3 inflammasome and Nrf2/HO-1 signaling, and may provide a novel Chinese patent medicine for the treatment of murine colitis[1].

    Animal Model: Forty-eight male C57BL/6 mice weighing 20-22 g[1].
    Dosage: 0.5 and 1 mg/kg.
    Administration: Intraperitoneal injection daily for 7 days.
    Result: Protected against DSS-induced colitis in mice.
    Inhibited the expression of proinflammatory cytokines in DSS-induced UC and improved oxidative stress.
    Molecular Weight

    574.62

    Formula

    C₃₀H₃₈O₁₁

    CAS No.

    58812-37-6

    SMILES
    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage

    4°C, protect from light

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

    Solvent & Solubility
    In Vitro: 

    DMSO : 250 mg/mL (435.07 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.7403 mL 8.7014 mL 17.4028 mL
    5 mM 0.3481 mL 1.7403 mL 3.4806 mL
    10 mM 0.1740 mL 0.8701 mL 1.7403 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.17 mg/mL (3.78 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.17 mg/mL (3.78 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.17 mg/mL (3.78 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References
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    Keywords:

    ToosendaninOthersInhibitorinhibitorinhibit

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    Product name:
    Toosendanin
    Cat. No.:
    HY-N0263
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